INT53290

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Context Info
Confidence 0.31
First Reported 1995
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 6.90
Pain Relevance 9.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (OPN1LW) plasma membrane (OPN1LW) signal transducer activity (OPN1LW)
Anatomy Link Frequency
nucleus pulposus 1
OPN1LW (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 1704 100.00 Very High Very High Very High
Trigeminal neuralgia 352 100.00 Very High Very High Very High
Pain 810 99.48 Very High Very High Very High
antidepressant 24 99.48 Very High Very High Very High
Gabapentin 128 97.04 Very High Very High Very High
depression 8 84.56 Quite High
Analgesic 112 82.48 Quite High
substance P 3 79.60 Quite High
Multiple sclerosis 32 78.20 Quite High
trigger zone 16 67.84 Quite High
Disease Link Frequency Relevance Heat
Neuralgia 360 100.00 Very High Very High Very High
Pain 858 99.48 Very High Very High Very High
Intervertebral Disk Degeneration 3 90.44 High High
Depression 16 84.56 Quite High
Hypersensitivity 32 84.36 Quite High
Epilepsy 8 84.08 Quite High
Stroke 8 83.68 Quite High
Diabetes Mellitus 8 83.36 Quite High
Demyelinating Disease 48 78.20 Quite High
Cancer 25 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding suggests that Rop and Bup can be used more safely than Mep in terms of placental transfer.


Gene_expression (used) of Rop
1) Confidence 0.31 Published 2009 Journal J Anesth Section Body Doc Link 19921362 Disease Relevance 0 Pain Relevance 0
No statistical significant differences were present between CBZ + ROP and CBZ groups of patients in what concerns age, sex, pain location (number of trigeminal branches affected), and facial side affected (P > 0.05 in all comparisons), showing that similar sets of patients were randomly allocated to both treatments.
Neg (No) Gene_expression (present) of ROP associated with pain and carbamazepine
2) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.72 Pain Relevance 0.85
Because a 2-point decrease in the mean NRS scale (0–10 scale) is considered the minimum clinical relevant difference in pain intensity when comparing the effect of two treatments,27–31 both the CBZ + ROP and CBZ protocols were clinically effective in reducing pain after a 4-week therapy.
Gene_expression (effective) of ROP associated with pain and carbamazepine
3) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.65 Pain Relevance 1.13
However, the clinical insecurity of a ROPonly protocol21 resulted, in the present study, in the evaluation of only two protocols, which allowed a study blinded also to the patients: CBZ monotherapy (with injection of saline) and CBZ + ROP (with injection of ROP).


Gene_expression (resulted) of ROP associated with carbamazepine
4) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.80 Pain Relevance 1.21
None of the patients included in the present study had participated in the previous TN study of our group.21 Patients were allocated to one of the following treatment protocols (Figure 1): i) protocol CBZ + ROP and ii) protocol CBZ.
Gene_expression (previous) of ROP associated with trigeminal neuralgia and carbamazepine
5) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.96 Pain Relevance 1.31
Protocol CBZ + ROP
Gene_expression (Protocol) of ROP associated with carbamazepine
6) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.82 Pain Relevance 1.22
No differences were found between patients from protocol CBZ + ROP (NRS1 = 9.1 ± 1.1) and protocol CBZ (NRS1 = 9.1 ± 1.4) (P = 0.887) (Figure 2; Table 2) in pain intensity at the beginning of the treatment (day 1).
Neg (No) Gene_expression (found) of ROP associated with pain and carbamazepine
7) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.95 Pain Relevance 1.32
No statistical significant differences were present between CBZ + ROP and CBZ groups of patients in what concerns age, sex, pain location (number of trigeminal branches affected), and facial side affected (P > 0.05 in all comparisons), showing that similar sets of patients were randomly allocated to both treatments.
Gene_expression (groups) of ROP associated with pain and carbamazepine
8) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.73 Pain Relevance 0.85
Effect of CBZ + ROP and CBZ protocols in pain control
Gene_expression (Effect) of ROP associated with pain and carbamazepine
9) Confidence 0.15 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004633 Disease Relevance 0.95 Pain Relevance 1.22
PPX was produced by CYP2C11 and 3A2, 4'-OH Rop by CYP1A2, and 3'-OH Rop by CYP1A2 and 2D1.
Gene_expression (produced) of Rop
10) Confidence 0.06 Published 1995 Journal Anesthesiology Section Body Doc Link 7832304 Disease Relevance 0 Pain Relevance 0
PPX was produced by CYP2C11 and 3A2, 4'-OH Rop by CYP1A2, and 3'-OH Rop by CYP1A2 and 2D1.
Gene_expression (produced) of Rop
11) Confidence 0.06 Published 1995 Journal Anesthesiology Section Body Doc Link 7832304 Disease Relevance 0 Pain Relevance 0
Thirty-four rats were divided into five groups: intact control; sham control; compressed nucleus pulposus (NP) injected with saline; and two OP-1 groups: COP-1 group (compression was continued after intradiscal OP-1 injection) and ROP-1 group (compression was released at the time of OP-1 injection).
Gene_expression (group) of ROP-1 in nucleus pulposus
12) Confidence 0.01 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17205567 Disease Relevance 0.32 Pain Relevance 0.04

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