INT5331

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.74
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
cartilage 2
muscles 2
extracellular matrix 2
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 100.00 Very High Very High Very High
metalloproteinase 12 100.00 Very High Very High Very High
cytokine 4 100.00 Very High Very High Very High
Snapping jaw 2 97.92 Very High Very High Very High
Arthritis 3 96.96 Very High Very High Very High
rheumatoid arthritis 5 96.76 Very High Very High Very High
Pain 8 95.12 Very High Very High Very High
Inflammatory response 1 89.32 High High
Enkephalin 1 84.84 Quite High
chemokine 10 83.84 Quite High
Disease Link Frequency Relevance Heat
Cancer 57 100.00 Very High Very High Very High
INFLAMMATION 16 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Malignant Neoplastic Disease 7 99.80 Very High Very High Very High
Adenocarcinoma 6 97.92 Very High Very High Very High
Temporomandibular Joint Syndrome 2 97.92 Very High Very High Very High
Arthritis 4 96.96 Very High Very High Very High
Rheumatoid Arthritis 6 96.76 Very High Very High Very High
Pain 9 95.12 Very High Very High Very High
Adhesions 4 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Translation of the huPSA was found to be initiated at the second of two possible start codons, as shown by studies with antibodies directed against peptide sequences of both potential N-terminal regions.
Positive_regulation (Translation) of Gene_expression (Translation) of PSA
1) Confidence 0.49 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9048733 Disease Relevance 0.07 Pain Relevance 0.08
Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma.
Positive_regulation (increases) of Gene_expression (expression) of metalloproteinase associated with adenocarcinoma, malignant neoplastic disease, necrosis, cancer and metalloproteinase
2) Confidence 0.07 Published 2006 Journal Cancer Res. Section Title Doc Link 16982746 Disease Relevance 1.33 Pain Relevance 0.18
AM; amniotic membrane, AMT; amniotic membrane transplantation, BCVA; the best corrected visual acuities, DLKP; deep lamellar keratoplasty, MMP; matrix metalloproteinase, TIMP; tissue inhibitor of metalloproteinase

Competing interests

Positive_regulation (matrix) of Gene_expression (membrane) of metalloproteinase associated with metalloproteinase
3) Confidence 0.05 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 0.65 Pain Relevance 0.19
It promotes the resolution system of cartilage matrix turnover through an increase in inflammatory cytokine and matrix metalloproteinase production by chondrocytes [22,23].
Positive_regulation (increase) of Gene_expression (production) of metalloproteinase in cartilage associated with inflammation, metalloproteinase and cytokine
4) Confidence 0.04 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.50 Pain Relevance 0.29
This paper, however, suggests that because increased joint load is believed to cause a greater expression of destructive metalloproteinase, it is appropriate to assess even the asymptomatic temporomandibular joint and the muscles of mastication for early objective signs of dysfunction or discomfort.
Positive_regulation (cause) of Gene_expression (expression) of metalloproteinase in muscles associated with snapping jaw and metalloproteinase
5) Confidence 0.01 Published 1992 Journal Cranio Section Abstract Doc Link 1302653 Disease Relevance 0.96 Pain Relevance 0.78
Our data argue for the requirement of "appropriate" extracellular matrix environment for optimal metalloproteinase expression (Manuscript in preparation).
Positive_regulation (requirement) of Gene_expression (expression) of metalloproteinase in extracellular matrix associated with metalloproteinase
6) Confidence 0.01 Published 2008 Journal Cancer Cell Int Section Body Doc Link PMC2474582 Disease Relevance 0.22 Pain Relevance 0.29

General Comments

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