INT53310

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Context Info
Confidence 0.41
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.51
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)
Anatomy Link Frequency
amygdala 4
medial 2
brain 2
Cfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 24 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
bradykinin 1 100.00 Very High Very High Very High
amygdala 148 99.92 Very High Very High Very High
gABA 48 96.24 Very High Very High Very High
Antinociceptive 4 96.00 Very High Very High Very High
depression 10 95.80 Very High Very High Very High
antinociception 2 94.68 High High
insula 2 92.52 High High
Thalamus 2 92.20 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 10 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 14 99.88 Very High Very High Very High
Hypersensitivity 5 99.32 Very High Very High Very High
Anxiety Disorder 271 97.04 Very High Very High Very High
Depression 10 95.80 Very High Very High Very High
Pressure Volume 2 Under Development 1 95.36 Very High Very High Very High
Stress 168 91.52 High High
Neuropathic Pain 10 87.16 High High
Hypotension 2 85.68 High High
Cancer 2 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
N-[1(R,S)-Carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate (cFP-AAF-pAB) is a potent, substrate-related, specific inhibitor of endopeptidase 24.15, an enzyme involved in the metabolism of bioactive peptides including bradykinin, neurotensin, and proenkephalin, and prodynorphin-derived enkephalin precursors.
Negative_regulation (inhibitor) of Gene_expression (precursors) of cFP associated with enkephalin and bradykinin
1) Confidence 0.41 Published 1993 Journal Peptides Section Abstract Doc Link 8134308 Disease Relevance 0.25 Pain Relevance 0.15
Stimulation of PFC produced by 1 microgram/kg of Met-Enk was completely blocked with 10 and 50 micrograms/kg of ICI 174864.
Negative_regulation (blocked) of Gene_expression (produced) of PFC
2) Confidence 0.29 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834369 Disease Relevance 0.43 Pain Relevance 0.59
infralimbic part of the medial PFC impair recall of extinction of
Negative_regulation (impair) of Gene_expression (part) of PFC in medial
3) Confidence 0.22 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838961 Disease Relevance 0.96 Pain Relevance 0.27
effect is due to a reduction in mPFC modulation of amygdala
Negative_regulation (reduction) of Gene_expression (modulation) of mPFC in amygdala associated with amygdala
4) Confidence 0.22 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838961 Disease Relevance 1.00 Pain Relevance 0.36
then cut into blocks containing the entire PFC, frozen on dry ice,
Negative_regulation (blocks) of Gene_expression (containing) of PFC
5) Confidence 0.22 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0.27 Pain Relevance 0.03
The 5-HT1B autoreceptor activity has previously been found to be different in PFC and DG (Adell et al., 2001), and indeed in our experiments the effect of local administration of citalopram on 5-HT levels was much smaller in DG than in the PFC which may suggest higher degree of local regulation in this brain region.
Negative_regulation (different) of Gene_expression (experiments) of PFC in brain
6) Confidence 0.18 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.42 Pain Relevance 0.12
ADHD: Attention-Deficit/Hyperactivity Disorder; MP: methylphenidate; PFC: prefrontal cortex; MA: methamphetamine; DA: dopamine; BLA: basolateral amygdala; CA: central amygdala

Competing interests

Negative_regulation (methylphenidate) of Gene_expression (dopamine) of PFC in amygdala associated with dopamine, attention deficit hyperactivity disorder and amygdala
7) Confidence 0.05 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2412842 Disease Relevance 0.20 Pain Relevance 0.32
In the mPFC of SNI rats, NR2B expression was down-regulated; however, this effect was reversed with repeated oral DCS.
Negative_regulation (regulated) of Gene_expression (expression) of mPFC associated with nervous system injury
8) Confidence 0.03 Published 2007 Journal Pain Section Abstract Doc Link 17449176 Disease Relevance 0.99 Pain Relevance 0.76
In the mPFC of SNI rats, NR2B expression was down-regulated; however, this effect was reversed with repeated oral DCS.
Negative_regulation (down) of Gene_expression (expression) of mPFC associated with nervous system injury
9) Confidence 0.03 Published 2007 Journal Pain Section Abstract Doc Link 17449176 Disease Relevance 0.99 Pain Relevance 0.76

General Comments

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