INT53311

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 4.39
Pain Relevance 6.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Cfp) cellular_component (Cfp) biological_process (Cfp)
Anatomy Link Frequency
cortex 8
thalamus 4
caudate nucleus 2
amygdala 2
Cfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 120 100.00 Very High Very High Very High
Hippocampus 78 100.00 Very High Very High Very High
Anterior cingulate 22 100.00 Very High Very High Very High
Nucleus accumbens 21 100.00 Very High Very High Very High
Dopamine 166 99.98 Very High Very High Very High
Lasting pain 12 99.80 Very High Very High Very High
projection neuron 8 99.04 Very High Very High Very High
Locus ceruleus 30 98.34 Very High Very High Very High
noradrenaline 90 97.86 Very High Very High Very High
GABAergic 10 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 7 99.92 Very High Very High Very High
Pain 13 99.80 Very High Very High Very High
Stress 321 98.68 Very High Very High Very High
Schizophrenia 57 97.82 Very High Very High Very High
Cognitive Disorder 41 96.80 Very High Very High Very High
Death 8 94.52 High High
Depression 12 91.68 High High
Anxiety Disorder 146 90.16 High High
Disseminated Intravascular Coagulation 6 84.24 Quite High
Immunization 2 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated the absolute concentration of N-acetylaspartate (NAA) in the anterior cingulated cortex (ACC), and prefrontal cortex (PFC) in chronic pain patients by proton magnetic resonance spectroscopy (1H-MRS). 1H-MRS was performed with a 1.5T MR system on a voxel in the thalamus, ACC, and PFC bilaterally, in 48 chronic pain patients and 23 normal control subjects.
Positive_regulation (cingulated) of Gene_expression (prefrontal) of PFC in thalamus associated with lasting pain, thalamus and anterior cingulate
1) Confidence 0.42 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411706 Disease Relevance 0.27 Pain Relevance 0.56
Stimulation of PFC produced by 1 microgram/kg of Met-Enk was completely blocked with 10 and 50 micrograms/kg of ICI 174864.
Positive_regulation (Stimulation) of Gene_expression (produced) of PFC
2) Confidence 0.32 Published 1994 Journal Brain Res. Section Abstract Doc Link 7834369 Disease Relevance 0.48 Pain Relevance 0.60
PFC slices were transferred to a submerged recording chamber,
Positive_regulation (transferred) of Gene_expression (transferred) of PFC
3) Confidence 0.26 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0.08 Pain Relevance 0.06
then cut into blocks containing the entire PFC, frozen on dry ice,
Positive_regulation (entire) of Gene_expression (containing) of PFC
4) Confidence 0.26 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0.27 Pain Relevance 0.03
Stereotaxic coordinates of the PFC
Positive_regulation (Stereotaxic) of Gene_expression (Stereotaxic) of PFC
5) Confidence 0.26 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0.26 Pain Relevance 0.04
In contrast, the increased phosphorylation of the Ser880-GluA2 residue in the mPFC that we observed suggests acute stress increases AMPAR internalization and facilitates the generation of LTD in that region.
Positive_regulation (increased) of Gene_expression (residue) of mPFC associated with stress
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.62 Pain Relevance 0.37
The increase in the extracellular concentration of ACh in the PFC produced by MDMA (10 mg/kg, i.p.) was significantly less in rats previously exposed to the neurotoxic regimen of MDMA than that in control animals.
Positive_regulation (increase) of Gene_expression (produced) of PFC in PFC
7) Confidence 0.15 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16624669 Disease Relevance 0.17 Pain Relevance 0.16
We investigated the absolute concentration of N-acetylaspartate (NAA) in the anterior cingulated cortex (ACC), and prefrontal cortex (PFC) in chronic pain patients by proton magnetic resonance spectroscopy (1H-MRS). 1H-MRS was performed with a 1.5T MR system on a voxel in the thalamus, ACC, and PFC bilaterally, in 48 chronic pain patients and 23 normal control subjects.
Positive_regulation (cingulated) of in PFC Gene_expression (prefrontal) of PFC in thalamus associated with lasting pain, thalamus and anterior cingulate
8) Confidence 0.14 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411706 Disease Relevance 0.27 Pain Relevance 0.56
We investigated the absolute concentration of N-acetylaspartate (NAA) in the anterior cingulated cortex (ACC), and prefrontal cortex (PFC) in chronic pain patients by proton magnetic resonance spectroscopy (1H-MRS). 1H-MRS was performed with a 1.5T MR system on a voxel in the thalamus, ACC, and PFC bilaterally, in 48 chronic pain patients and 23 normal control subjects.
Positive_regulation (cingulated) of in ACC Gene_expression (prefrontal) of PFC in thalamus associated with lasting pain, thalamus and anterior cingulate
9) Confidence 0.14 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 18411706 Disease Relevance 0.27 Pain Relevance 0.56
The increase in CBF caused by hemodilution with PFC emulsion has long been recognized; the mechanisms by which PFC emulsions increase CBF are probably multifactorial.
Positive_regulation (increase) of Gene_expression (emulsions) of PFC
10) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291566 Disease Relevance 0.25 Pain Relevance 0.07
By means of the double probe preparation, we demonstrated that the NA increase produced by LC electrical stimulation is elicited both in the mPFC and caudate nucleus, while DA increase is present in the mPFC but not in the caudate nucleus.
Positive_regulation (increase) of Neg (not) Gene_expression (present) of mPFC in caudate nucleus associated with dopamine, locus ceruleus and noradrenaline
11) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1134661 Disease Relevance 0 Pain Relevance 0.82
Another proposed mechanism underlying cognitive dysfunction and negative symptoms in schizophrenia is dopaminergic hypofunction in the prefrontal cortex (PFC).58 Sertindole, as well as risperidone, markedly increased the extracellular levels of DA in medial PFC and nucleus accumbens of conscious rats; differently from risperidone, sertindole also enhanced extracellular levels of acetylcoline (ACh) and glutamate (Glu) in the rat mPFC.20 It has been hypothesized that potentiation of insufficient dopaminergic and glutamatergic transmission and strengthening of the cholinergic transmission in the PFC may explain the beneficial effects of sertindole on cognitive function in patients with schizophrenia,20,54 and the superior effect against negative symptoms compared to risperidone reported in a clinical study on sertindole and risperidone.49
Positive_regulation (increased) of Gene_expression (nucleus accumbens) of PFC in cortex associated with nucleus accumbens, cognitive disorder, glutamate and schizophrenia
12) Confidence 0.09 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939763 Disease Relevance 0.83 Pain Relevance 0.15
This may at first seem surprising in view of evidence suggesting that mPFC lesions can increase the responsiveness of NAc DA (e.g.
Positive_regulation (increase) of Gene_expression (lesions) of mPFC associated with nucleus accumbens and dopamine
13) Confidence 0.09 Published 2010 Journal Neuroscience Section Body Doc Link PMC2930211 Disease Relevance 0 Pain Relevance 0.49
This work in cell culture systems is consistent with our finding of increased developmental expression of TRPC5 in HIP, PFC, SUB, and entorhinal cortex.
Positive_regulation (increased) of Gene_expression (expression) of PFC in cortex associated with hippocampus
14) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.27
To test this, we co-transfected PFC cultures with ?
Positive_regulation (transfected) of Gene_expression (transfected) of PFC
15) Confidence 0.04 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.11
To test this, we co-transfected PFC cultures with ?
Positive_regulation (transfected) of Gene_expression (cultures) of PFC
16) Confidence 0.04 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.11
Therefore, the changes we observed in ERK expression in the mPFC as a result of NAL administration could be mediated by the direct or indirect connections from the vlPAG to mPFC.
Positive_regulation (mediated) of Gene_expression (expression) of mPFC associated with narcan
17) Confidence 0.02 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.20 Pain Relevance 0.55
Briefly, excitation of mPFC increases activity of excitatory projection neurons from the mPFC to GABAergic intercalated cells in the amygdala.
Positive_regulation (increases) of Gene_expression (excitation) of mPFC in amygdala associated with gabaergic, projection neuron and amygdala
18) Confidence 0.02 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.28 Pain Relevance 0.64
These results are very similar to previous data showing that FOS protein expression increases in the mPFC following extinction training (Santini et al., 2004), and recent results examining CREB activity in the mPFC following extinction training of different lengths (Mamiya et al., 2009).
Positive_regulation (increases) of Gene_expression (expression) of mPFC
19) Confidence 0.02 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.06 Pain Relevance 0.23
Significantly elevated pERK levels in the mPFC were specific to the group that received 40 extinction trials.
Positive_regulation (elevated) of Gene_expression (levels) of mPFC
20) Confidence 0.02 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.07 Pain Relevance 0.25

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