INT5332

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Context Info
Confidence 0.04
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.79
Pain Relevance 4.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
placenta 4
joint 2
tendon cells 2
liver 1
uterus 1
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 208 100.00 Very High Very High Very High
cytokine 67 100.00 Very High Very High Very High
Inflammation 146 99.80 Very High Very High Very High
Leflunomide 15 95.68 Very High Very High Very High
Inflammatory mediators 13 94.36 High High
Snapping jaw 2 93.16 High High
Pain 27 91.04 High High
corticosteroid 7 87.88 High High
methotrexate 14 87.08 High High
rheumatoid arthritis 83 84.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 187 99.80 Very High Very High Very High
Osteoarthritis 3 99.76 Very High Very High Very High
Injury 50 98.24 Very High Very High Very High
Stress 6 97.40 Very High Very High Very High
Carcinoma 6 96.28 Very High Very High Very High
Metastasis 61 95.52 Very High Very High Very High
Temporomandibular Joint Syndrome 2 93.16 High High
Adhesions 52 93.12 High High
Pain 27 91.04 High High
Pressure And Volume Under Development 8 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AM; amniotic membrane, AMT; amniotic membrane transplantation, BCVA; the best corrected visual acuities, DLKP; deep lamellar keratoplasty, MMP; matrix metalloproteinase, TIMP; tissue inhibitor of metalloproteinase

Competing interests

Negative_regulation (inhibitor) of Gene_expression (membrane) of metalloproteinase associated with metalloproteinase
1) Confidence 0.04 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 0.65 Pain Relevance 0.19
Hyaluronan inhibited interleukin-1beta-induced metalloproteinase production from osteoarthritic synovial tissue by a process that was not solely dependent on hyaluronan molecular mass but that was partly mediated by hyaluronan binding to CD44.
Negative_regulation (inhibited) of Gene_expression (production) of metalloproteinase associated with metalloproteinase and osteoarthritis
2) Confidence 0.03 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.29 Pain Relevance 0.39
Recent findings showed that the expression of MMP and tissue inhibitor of metalloproteinase (TIMP) in tendon cells were sensitive to mechanical overload or stress-deprivation [131,154].
Negative_regulation (inhibitor) of Gene_expression (expression) of metalloproteinase in tendon cells associated with stress and metalloproteinase
3) Confidence 0.02 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC3006368 Disease Relevance 1.61 Pain Relevance 0.43
Interceptive management, by the use of load-reducing appliance therapy, may enable reduction of the expression of destructive metalloproteinase within the joint, thereby reducing joint destruction.
Negative_regulation (reduction) of Gene_expression (expression) of metalloproteinase in joint associated with metalloproteinase
4) Confidence 0.02 Published 1992 Journal Cranio Section Abstract Doc Link 1302653 Disease Relevance 0.86 Pain Relevance 0.72
Diets supplemented with DHA reduce the metalloproteinase production in uterus, placenta, and liver tissues of rat.
Negative_regulation (reduce) of Gene_expression (production) of metalloproteinase in placenta associated with metalloproteinase
5) Confidence 0.01 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.45 Pain Relevance 0.12
Upregulation of tissue inhibitor of metalloproteinase expression can inhibit the degradation of ECM components, resulting in an amplification of this effect.
Negative_regulation (inhibitor) of Gene_expression (expression) of metalloproteinase associated with metalloproteinase
6) Confidence 0.01 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.89 Pain Relevance 0.56
Genistein can decrease matrix metalloproteinase expression
Negative_regulation (decrease) of Gene_expression (expression) of metalloproteinase associated with metalloproteinase
7) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.51 Pain Relevance 0.26
B signaling, reduces matrix metalloproteinase expression and inflammatory cytokine production [51], [59], [60], [61], [62].
Negative_regulation (reduces) of Gene_expression (expression) of metalloproteinase associated with inflammation, metalloproteinase and cytokine
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.51 Pain Relevance 0.81
Diets supplemented with DHA reduce the metalloproteinase production in uterus, placenta, and liver tissues of rat.
Negative_regulation (reduce) of in uterus Gene_expression (production) of metalloproteinase in placenta associated with metalloproteinase
9) Confidence 0.00 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.45 Pain Relevance 0.12
Diets supplemented with DHA reduce the metalloproteinase production in uterus, placenta, and liver tissues of rat.
Negative_regulation (reduce) of in liver Gene_expression (production) of metalloproteinase in placenta associated with metalloproteinase
10) Confidence 0.00 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.45 Pain Relevance 0.12
A decrease of cytokine-regulated metalloproteinase expression results in normalization of circulating MMP-1 and MMP-3 levels.
Negative_regulation (decrease) of Gene_expression (expression) of metalloproteinase associated with metalloproteinase and cytokine
11) Confidence 0.00 Published 1998 Journal Z Rheumatol Section Abstract Doc Link 9864833 Disease Relevance 1.13 Pain Relevance 0.56

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