INT5333

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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 26.34
Pain Relevance 15.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
temporomandibular joint 3
chondrocytes 2
macrophages 2
extracellular matrix 2
IVD 2
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 339 100.00 Very High Very High Very High
Osteoarthritis 122 100.00 Very High Very High Very High
cytokine 208 99.92 Very High Very High Very High
Dismenorea 4 99.84 Very High Very High Very High
Inflammation 339 99.80 Very High Very High Very High
Snapping jaw 22 99.56 Very High Very High Very High
cINOD 19 99.28 Very High Very High Very High
COX2 4 98.00 Very High Very High Very High
endometriosis 6 96.76 Very High Very High Very High
rheumatoid arthritis 176 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 107 100.00 Very High Very High Very High
Cancer 282 99.84 Very High Very High Very High
Dysmenorrhea 4 99.84 Very High Very High Very High
INFLAMMATION 382 99.80 Very High Very High Very High
Necrosis 22 99.60 Very High Very High Very High
Hypoxia 33 99.56 Very High Very High Very High
Temporomandibular Joint Syndrome 22 99.56 Very High Very High Very High
Adhesions 195 99.12 Very High Very High Very High
Autoimmune Disease 29 98.68 Very High Very High Very High
Injury 201 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Translation of the huPSA was found to be initiated at the second of two possible start codons, as shown by studies with antibodies directed against peptide sequences of both potential N-terminal regions.
Gene_expression (Translation) of PSA
1) Confidence 0.65 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9048733 Disease Relevance 0.07 Pain Relevance 0.08
Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons.
Gene_expression (expression) of puromycin-sensitive aminopeptidase in neurons
2) Confidence 0.47 Published 1997 Journal J. Neurochem. Section Title Doc Link 9048733 Disease Relevance 0.07 Pain Relevance 0.10
There are elevated levels of matrix metalloproteinase and inflammatory cytokines, decreased levels of metalloproteinase tissue inhibitors, and growth factors in the chronic wound environment (Templeton 2005; Wright et al 2003).
Gene_expression (levels) of metalloproteinase associated with inflammation, injury, metalloproteinase and cytokine
3) Confidence 0.32 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676636 Disease Relevance 2.28 Pain Relevance 0.27
OBJECTIVE: To study the expression of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) in tissue samples of deformed human temporomandibular joint (TMJ) discs and cells obtained from the discs.
Gene_expression (expression) of metalloproteinase in temporomandibular joint associated with snapping jaw and metalloproteinase
4) Confidence 0.14 Published 2008 Journal Histol. Histopathol. Section Abstract Doc Link 18830934 Disease Relevance 0.17 Pain Relevance 0.22
Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma.
Gene_expression (expression) of metalloproteinase associated with adenocarcinoma, malignant neoplastic disease, necrosis, cancer and metalloproteinase
5) Confidence 0.11 Published 2006 Journal Cancer Res. Section Title Doc Link 16982746 Disease Relevance 1.30 Pain Relevance 0.17
Pentoxifylline (POF) has been shown to have anti-inflammatory and immunomodulatory effects. including suppression of TNF-alpha production by activated macrophages, Th-1 response of T cells, and fibroblasts' proliferation and metalloproteinase production.
Gene_expression (production) of metalloproteinase in macrophages associated with inflammation and metalloproteinase
6) Confidence 0.09 Published 1997 Journal Ryumachi Section Abstract Doc Link 9492569 Disease Relevance 0.47 Pain Relevance 0.25
AM; amniotic membrane, AMT; amniotic membrane transplantation, BCVA; the best corrected visual acuities, DLKP; deep lamellar keratoplasty, MMP; matrix metalloproteinase, TIMP; tissue inhibitor of metalloproteinase

Competing interests

Gene_expression (membrane) of metalloproteinase associated with metalloproteinase
7) Confidence 0.07 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1913057 Disease Relevance 0.65 Pain Relevance 0.19
Available data on the role for mechanical factors on the disk chondrocyte metabolism and on metalloproteinase production show that mechanical and metabolic factors interact closely to produce disk disorders.
Gene_expression (production) of metalloproteinase in chondrocyte associated with metalloproteinase
8) Confidence 0.05 Published 2001 Journal Joint Bone Spine Section Abstract Doc Link 11808997 Disease Relevance 0.33 Pain Relevance 0.36
We describe the presence of a matrix metalloproteinase, MMP9 (92-kD gelatinase), in TMJ disc and articular cells that likely function in the degradative process.
Gene_expression (presence) of metalloproteinase in TMJ associated with snapping jaw and metalloproteinase
9) Confidence 0.04 Published 2001 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 11455120 Disease Relevance 0.68 Pain Relevance 0.82
It promotes the resolution system of cartilage matrix turnover through an increase in inflammatory cytokine and matrix metalloproteinase production by chondrocytes [22,23].
Gene_expression (production) of metalloproteinase in cartilage associated with inflammation, metalloproteinase and cytokine
10) Confidence 0.04 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.49 Pain Relevance 0.28
In vitro studies indicate that osteonectin can bind collagen and regulate angiogenesis, metalloproteinase expression, cell proliferation, and cell-matrix interactions [15].
Gene_expression (expression) of metalloproteinase associated with metalloproteinase
11) Confidence 0.04 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2831027 Disease Relevance 0.82 Pain Relevance 0.41
Matrix metalloproteinase levels and gelatinolytic activity in clinically healthy and inflamed human dental pulps.
Gene_expression (levels) of metalloproteinase in dental pulps associated with metalloproteinase
12) Confidence 0.04 Published 2002 Journal Eur. J. Oral Sci. Section Title Doc Link 12664465 Disease Relevance 0.08 Pain Relevance 0.27
Recent findings showed that the expression of MMP and tissue inhibitor of metalloproteinase (TIMP) in tendon cells were sensitive to mechanical overload or stress-deprivation [131,154].
Gene_expression (expression) of metalloproteinase in tendon cells associated with stress and metalloproteinase
13) Confidence 0.04 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC3006368 Disease Relevance 1.61 Pain Relevance 0.43
Hyaluronan inhibited interleukin-1beta-induced metalloproteinase production from osteoarthritic synovial tissue by a process that was not solely dependent on hyaluronan molecular mass but that was partly mediated by hyaluronan binding to CD44.
Gene_expression (production) of metalloproteinase associated with metalloproteinase and osteoarthritis
14) Confidence 0.04 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.28 Pain Relevance 0.39
Degeneration is characterized by increased degradation of the normal IVD matrix by locally produced matrix metalloproteinases (MMPs) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) [3-6].
Gene_expression (produced) of metalloproteinase in IVD associated with metalloproteinase
15) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.28 Pain Relevance 0.37
Furthermore, a correlation was observed between p16INK4a expression and the expression of matrix-degrading enzymes matrix metalloproteinase (MMP)-13 and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5, suggesting a role for cell senescence in the molecular processes observed during IVD degeneration [18].
Gene_expression (expression) of metalloproteinase associated with aging and metalloproteinase
16) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.18 Pain Relevance 0.19
Furthermore, a correlation was observed between p16INK4a expression and the expression of matrix-degrading enzymes matrix metalloproteinase (MMP)-13 and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5, suggesting a role for cell senescence in the molecular processes observed during IVD degeneration [18].
Gene_expression (expression) of metalloproteinase associated with aging and metalloproteinase
17) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.15 Pain Relevance 0.19
This paper, however, suggests that because increased joint load is believed to cause a greater expression of destructive metalloproteinase, it is appropriate to assess even the asymptomatic temporomandibular joint and the muscles of mastication for early objective signs of dysfunction or discomfort.
Gene_expression (expression) of metalloproteinase in muscles associated with snapping jaw and metalloproteinase
18) Confidence 0.02 Published 1992 Journal Cranio Section Abstract Doc Link 1302653 Disease Relevance 0.96 Pain Relevance 0.78
Interceptive management, by the use of load-reducing appliance therapy, may enable reduction of the expression of destructive metalloproteinase within the joint, thereby reducing joint destruction.
Gene_expression (expression) of metalloproteinase in joint associated with metalloproteinase
19) Confidence 0.02 Published 1992 Journal Cranio Section Abstract Doc Link 1302653 Disease Relevance 0.85 Pain Relevance 0.71
The isolation of fibroblasts from mesothelial cells were also verified by the RT-PCR detection of Collagen type I, Matrix metalloproteinase-2 (MMP-2) and Transforming growth factor-?
Gene_expression (detection) of metalloproteinase in mesothelial cells associated with metalloproteinase
20) Confidence 0.02 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.32 Pain Relevance 0.12

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