INT53347

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.96
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BDKRB2) plasma membrane (BDKRB2) signal transducer activity (BDKRB2)
Anatomy Link Frequency
epithelial cells 1
fibroblasts 1
bowel 1
BDKRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 229 100.00 Very High Very High Very High
b2 receptor 41 100.00 Very High Very High Very High
antagonist 14 100.00 Very High Very High Very High
Angina 6 99.62 Very High Very High Very High
Inflammation 68 99.20 Very High Very High Very High
Pain 62 95.76 Very High Very High Very High
cytokine 14 85.24 High High
Crohn's disease 4 76.80 Quite High
Kinase C 6 54.08 Quite High
B1 receptor 34 53.96 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 6 99.62 Very High Very High Very High
Myocardial Infarction 6 99.28 Very High Very High Very High
Inflammatory Bowel Disease 11 99.20 Very High Very High Very High
Diabetes Mellitus 207 97.12 Very High Very High Very High
INFLAMMATION 71 96.96 Very High Very High Very High
Pain 66 95.76 Very High Very High Very High
Increased Venous Pressure Under Development 11 95.52 Very High Very High Very High
Disease 13 77.96 Quite High
Injury 64 76.76 Quite High
Granuloma 1 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, cellular localization of B1 and B2 receptor in the present study could be gingival fibroblasts, epithelial cells in oral mucosa or the inflammatory cellular infiltrate.
Localization (localization) of B2 receptor in epithelial cells associated with inflammation and b2 receptor
1) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.59 Pain Relevance 0.65
Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor.
Localization (localization) of BDKRB2 associated with b2 receptor
2) Confidence 0.75 Published 1994 Journal Genomics Section Title Doc Link 7835885 Disease Relevance 0.28 Pain Relevance 0.41
Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease.
Localization (Immunolocalization) of B2R in bowel associated with inflammation
3) Confidence 0.73 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 15805101 Disease Relevance 1.38 Pain Relevance 0.67
In contrast to our earlier study, where patients with acute myocardial infarction or stable angina showed diminished abundance of B2R on CPCs, we could not detect any significant difference in kinin-receptor expression between cells from T1D and H donors [11].
Localization (abundance) of B2R associated with angina, diabetes mellitus and myocardial infarction
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.92 Pain Relevance 0.21
BKmig derived from H PBMC generated NO in response to BK stimulation through a mechanism involving both kinin receptors (being similarly blunted by B1R antagonist LdA-BK and B2R antagonist icatibant) and eNOS (being totally blocked by L-NIO), while T1D BKmig did not (Fig. 7A).
Localization (blunted) of LdA-BK associated with diabetes mellitus, antagonist and bradykinin
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.61 Pain Relevance 0.39
Thus, cellular localization of B1 and B2 receptor in the present study could be gingival fibroblasts, epithelial cells in oral mucosa or the inflammatory cellular infiltrate.
Localization (localization) of B2 receptor in fibroblasts associated with inflammation and b2 receptor
6) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2834653 Disease Relevance 0.59 Pain Relevance 0.65
BKmig derived from H PBMC generated NO in response to BK stimulation through a mechanism involving both kinin receptors (being similarly blunted by B1R antagonist LdA-BK and B2R antagonist icatibant) and eNOS (being totally blocked by L-NIO), while T1D BKmig did not (Fig. 7A).
Localization (blunted) of B2R associated with diabetes mellitus, antagonist and bradykinin
7) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887352 Disease Relevance 0.61 Pain Relevance 0.39

General Comments

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