INT53348

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Context Info
Confidence 0.37
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.85
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (BDKRB2) plasma membrane (BDKRB2) signal transducer activity (BDKRB2)
Anatomy Link Frequency
smooth muscle 1
bridge 1
BDKRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
b2 receptor 30 100.00 Very High Very High Very High
bradykinin 22 100.00 Very High Very High Very High
aspirin 9 99.46 Very High Very High Very High
Dopamine 3 98.40 Very High Very High Very High
Inflammation 13 97.28 Very High Very High Very High
Potency 2 97.04 Very High Very High Very High
Pain 4 96.72 Very High Very High Very High
agonist 87 92.64 High High
Hyperalgesia 2 88.80 High High
antagonist 20 87.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 97.28 Very High Very High Very High
Pain 4 96.72 Very High Very High Very High
Increased Venous Pressure Under Development 9 95.72 Very High Very High Very High
Diabetic Retinopathy 26 93.20 High High
Toxicity 1 90.20 High High
Brain Injury 25 88.80 High High
Hyperalgesia 2 88.80 High High
Pressure And Volume Under Development 13 88.24 High High
Retinal Diseases 5 86.68 High High
Diabetes Mellitus 61 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The bradykinin B2 receptor (BDKRB2) has high affinity for the intact kinins, which mediate a wide spectrum of biological effects, including pain, inflammation, vasodilation, and smooth muscle contraction and relaxation.
BDKRB2 Binding (affinity) of in smooth muscle associated with pain, inflammation, b2 receptor and increased venous pressure under development
1) Confidence 0.37 Published 1994 Journal Genomics Section Abstract Doc Link 7835885 Disease Relevance 0.29 Pain Relevance 0.34
The affinity of (S)-14 g for the human B2 receptor suggested that it may be a hydrophobic interaction with the ethane bridge of the DBS moiety that accounts for the increased potency of compounds (S)-14d,e and 19b,c at this receptor, by favoring a binding mode inaccessible to the unsubstituted diphenylmethyl derivative, (S)-4.
B2 receptor Binding (interaction) of in bridge associated with b2 receptor and potency
2) Confidence 0.31 Published 2002 Journal J. Med. Chem. Section Abstract Doc Link 12014954 Disease Relevance 0.09 Pain Relevance 0.59
Anatibant inhibits the binding of BK to the B2 receptor.
B2 receptor Binding (binding) of associated with b2 receptor and bradykinin
3) Confidence 0.31 Published 2009 Journal Trials Section Body Doc Link PMC2794266 Disease Relevance 0.99 Pain Relevance 0.76
Aspirin inhibits human bradykinin B2 receptor ligand binding function.
B2 receptor Binding (binding) of associated with aspirin and b2 receptor
4) Confidence 0.30 Published 2008 Journal Biochem. Pharmacol. Section Title Doc Link 18355801 Disease Relevance 0.35 Pain Relevance 1.00
Moreover, direct physical interaction between the bradykinin B2 receptor and eNOS yields a reversible inhibitory complex that is readily dissociated on ligand binding and/or elevations in [Ca2+]i, thereby providing another counter-regulatory mechanism between GPCR/Ca2+- and NOS/cGMP-regulated signalling systems [81].
bradykinin B2 receptor Binding (interaction) of associated with b2 receptor
5) Confidence 0.06 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.17
The method has confirmed that alteration of the BRB.
BRB Binding (alteration) of
6) Confidence 0.06 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693968 Disease Relevance 1.13 Pain Relevance 0.04
AT1R undergoes homo- and heterodimerize with many other receptors, including bradykinin B2, ?
bradykinin B2 Binding (receptors) of associated with bradykinin
7) Confidence 0.04 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0.10

General Comments

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