INT5337

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 87
Total Number 89
Disease Relevance 19.60
Pain Relevance 46.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
plasma 10
ARC 5
nucleus 4
sympathetic 4
hypothalamus 4
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 219 100.00 Very High Very High Very High
antagonist 66 100.00 Very High Very High Very High
Enkephalin 61 100.00 Very High Very High Very High
noradrenaline 24 100.00 Very High Very High Very High
opioid receptor 19 100.00 Very High Very High Very High
Snapping jaw 17 100.00 Very High Very High Very High
Dynorphin 5 100.00 Very High Very High Very High
fluoxetine 45 99.98 Very High Very High Very High
algil 19 99.98 Very High Very High Very High
Antinociceptive 6 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 23 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 17 100.00 Very High Very High Very High
Sprains And Strains 17 99.76 Very High Very High Very High
Urological Neuroanatomy 31 99.72 Very High Very High Very High
Hypertension 21 99.56 Very High Very High Very High
Obesity 34 99.28 Very High Very High Very High
Aging 8 99.22 Very High Very High Very High
Arthritis 16 99.04 Very High Very High Very High
Middle Cerebral Artery Infarction 5 98.76 Very High Very High Very High
Diabetes Mellitus 15 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Downregulation of the NPY Y1 receptor gene using an antisense oligodeoxynucleotide produced a doubling of the infarct volume, implying that NPY may mediate neuroprotection against focal ischemia.
Negative_regulation (Downregulation) of NPY associated with ischemia
1) Confidence 0.59 Published 2002 Journal Brain Res. Section Abstract Doc Link 11821007 Disease Relevance 0.56 Pain Relevance 0.18
In addition, we observed a significant decrease of the NPY levels in the hypothalamus, the striatum and the adrenal glands.
Negative_regulation (decrease) of NPY in hypothalamus
2) Confidence 0.59 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1761199 Disease Relevance 0 Pain Relevance 0.57
In addition, we observed a significant decrease of NPY levels in the hypothalamus, the striatum and the adrenal glands.
Negative_regulation (decrease) of NPY in striatum
3) Confidence 0.59 Published 1992 Journal Gen. Pharmacol. Section Abstract Doc Link 1639229 Disease Relevance 0 Pain Relevance 0.52
The inhibitory effect of NPY is mediated through PT-sensitive G protein.
Negative_regulation (effect) of NPY
4) Confidence 0.58 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1359017 Disease Relevance 0.22 Pain Relevance 0.28
These results reveal that the chronic administration of fluoxetine decreases expression levels in both NPY and POMC in the brain, and suggests that fluoxetine-induced anorexia may not be mediated by changes in the ARC expression of either NPY or POMC.
Negative_regulation (decreases) of NPY in ARC associated with aids-related complex, anorexia and fluoxetine
5) Confidence 0.58 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.67 Pain Relevance 0.92
Either alpha 2-adrenergic receptor blockade (yohimbine) or occupancy (clonidine) prevent NPY inhibition of AVP-stimulated Lp.
Negative_regulation (inhibition) of NPY associated with clonidine
6) Confidence 0.57 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2538078 Disease Relevance 0.09 Pain Relevance 0.22
Extrinsic denervation caused a total loss of NPY/TH-, SP/CGRP- and SP/CGRP/VIP/NOS/PACAP-containing nerve fibres.
Negative_regulation (loss) of NPY in nerve associated with calcitonin gene-related peptide and substance p
7) Confidence 0.57 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12132647 Disease Relevance 0 Pain Relevance 0.88
In the FSL rats, NPY mRNA expression levels were significantly decreased in the nucleus accumbens and CA regions, but increased in the arcuate nucleus and anterior cingulate cortex.
Negative_regulation (decreased) of NPY in anterior associated with nucleus accumbens and anterior cingulate cortex
8) Confidence 0.56 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.37 Pain Relevance 0.59
Direct inhibition of plasma NPY-IR through an activation of opioid receptors can thus be considered.
Negative_regulation (inhibition) of plasma NPY-IR in plasma associated with opioid receptor
9) Confidence 0.51 Published 1992 Journal Ma Zui Xue Za Zhi Section Abstract Doc Link 1302786 Disease Relevance 0.23 Pain Relevance 0.65
Pethidine reduced the plasma NPY-IR level which could be reversed by naloxone.
Negative_regulation (reduced) of plasma NPY-IR in plasma associated with narcan and algil
10) Confidence 0.51 Published 1992 Journal Ma Zui Xue Za Zhi Section Abstract Doc Link 1302786 Disease Relevance 0.21 Pain Relevance 0.61
The obtained results suggest that premedication of diazepam and/or pethidine has the ability to decrease plasma NPY-IR in animals.
Negative_regulation (decrease) of plasma NPY-IR in plasma associated with algil
11) Confidence 0.51 Published 1992 Journal Ma Zui Xue Za Zhi Section Abstract Doc Link 1302786 Disease Relevance 0.24 Pain Relevance 0.78
After 14 and 56 days of imipramine treatment, Arc NPY mRNA levels are decreased to 85% and 75% of control levels, but are unchanged compared to control after one or five days of treatment.
Negative_regulation (decreased) of Arc NPY in Arc associated with aids-related complex
12) Confidence 0.51 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.51 Pain Relevance 0.40
Evidence is also presented for the existence of a glucocorticoid regulation of NPY IR neurons, especially of those innervating the locus coeruleus, since after 2 weeks adrenalectomy reduced NPY IR in this area.
Negative_regulation (reduced) of NPY IR in neurons associated with locus ceruleus
13) Confidence 0.45 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455156 Disease Relevance 0.08 Pain Relevance 0.34
The inhibitory action of neuropeptide Y (NPY) on the muscular activity of the prostatic end of the rat vas deferens elicited by transmural electrical stimulation was examined in control and in reserpinized rats.
Spec (examined) Negative_regulation (action) of NPY in vas deferens associated with neuropeptide
14) Confidence 0.43 Published 1985 Journal Neurosci. Lett. Section Abstract Doc Link 2997668 Disease Relevance 0 Pain Relevance 0.28
The inhibitory action of neuropeptide Y (NPY) on the muscular activity of the prostatic end of the rat vas deferens elicited by transmural electrical stimulation was examined in control and in reserpinized rats.
Spec (examined) Negative_regulation (action) of neuropeptide Y in vas deferens associated with neuropeptide
15) Confidence 0.43 Published 1985 Journal Neurosci. Lett. Section Abstract Doc Link 2997668 Disease Relevance 0 Pain Relevance 0.28
A decrease in NPY immunostaining in the paraventricular nucleus, without changes in the arcuate, was observed.
Negative_regulation (decrease) of NPY in nucleus
16) Confidence 0.43 Published 2002 Journal Obes. Res. Section Body Doc Link 12055330 Disease Relevance 0 Pain Relevance 0
The present study confirmed the inhibitory effect of NPY on withdrawal behavior.
Negative_regulation (effect) of NPY associated with withdrawal
17) Confidence 0.43 Published 2001 Journal J. Neurosci. Res. Section Abstract Doc Link 11340648 Disease Relevance 0.23 Pain Relevance 1.26
On the other hand, the hypothalamic content of NPY was unaffected in early postnatal period in newborn males as well as in females.
Neg (unaffected) Negative_regulation (unaffected) of NPY
18) Confidence 0.43 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8829146 Disease Relevance 0.05 Pain Relevance 0.46
Clinically, we found that plasma neuropeptide Y-like immunoreactivity (NPY-IR) was lowered in patients who had received premedication.
Negative_regulation (lowered) of NPY-IR in plasma associated with neuropeptide
19) Confidence 0.43 Published 1992 Journal Ma Zui Xue Za Zhi Section Abstract Doc Link 1302786 Disease Relevance 0.13 Pain Relevance 0.46
Needling on Zusanli resulted in decreased NPY levels in both the ARN and PVN of diabetic rats.
Negative_regulation (decreased) of NPY in PVN associated with diabetes mellitus
20) Confidence 0.43 Published 2004 Journal Acupunct Electrother Res Section Abstract Doc Link 15382790 Disease Relevance 0.36 Pain Relevance 0.36

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