INT53373

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Context Info
Confidence 0.45
First Reported 1994
Last Reported 2001
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn3) extracellular region (Edn3)
Anatomy Link Frequency
neural crest cells 2
Edn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 3 99.98 Very High Very High Very High
tail-flick 1 95.08 Very High Very High Very High
anesthesia 2 25.00 Low Low
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hirschsprung Disease 2 97.56 Very High Very High Very High
Disease 6 92.20 High High
Central Hypoventilation Syndrome 6 90.84 High High
Hypoxia 4 68.40 Quite High
Hypercapnia 2 53.28 Quite High
Targeted Disruption 2 51.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined whether endothelin-3 (ET-3), one of the developmental regulators of neural crest cells and of which null mutation results in aganglionic megacolon in mice, fulfills the requirements for such a common molecule.
Spec (whether) Regulation (regulators) of ET-3 in neural crest cells associated with hirschsprung disease
1) Confidence 0.45 Published 2001 Journal Respir Physiol Section Abstract Doc Link 11084198 Disease Relevance 0.69 Pain Relevance 0
We examined whether endothelin-3 (ET-3), one of the developmental regulators of neural crest cells and of which null mutation results in aganglionic megacolon in mice, fulfills the requirements for such a common molecule.
Spec (whether) Regulation (regulators) of endothelin-3 in neural crest cells associated with hirschsprung disease
2) Confidence 0.45 Published 2001 Journal Respir Physiol Section Abstract Doc Link 11084198 Disease Relevance 0.69 Pain Relevance 0
L-NAME showed slight insignificant antinociceptive action, but augmented significantly the antinociceptive effects of i.c.v. administered ET-1 and ET-3 in both experimental tests.
Regulation (effects) of ET-3 associated with antinociceptive
3) Confidence 0.43 Published 1994 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 7837829 Disease Relevance 0 Pain Relevance 0.18

General Comments

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