INT53374

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 11.66
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
endothelial cells 2
tail 2
plasma 1
lung 1
embryonic kidney 1
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 7 99.98 Very High Very High Very High
Angina 25 99.36 Very High Very High Very High
qutenza 8 95.92 Very High Very High Very High
Root ganglion neuron 3 95.40 Very High Very High Very High
withdrawal 2 94.68 High High
Inflammation 88 93.12 High High
Thermal hyperalgesia 7 92.88 High High
tail-flick 2 90.52 High High
antagonist 11 82.72 Quite High
Kinase C 15 77.68 Quite High
Disease Link Frequency Relevance Heat
Coronary Vasospasm 2 100.00 Very High Very High Very High
Pain 5 99.98 Very High Very High Very High
Microvascular Angina 1 99.76 Very High Very High Very High
Cv General 2 Under Development 1 99.72 Very High Very High Very High
Apoptosis 27 99.60 Very High Very High Very High
Angina 11 99.36 Very High Very High Very High
Hypertension 34 99.24 Very High Very High Very High
Adhesions 66 99.04 Very High Very High Very High
Natriuresis 29 98.68 Very High Very High Very High
Death 66 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, elevated plasma endothelin-1 (ET-1) levels have been reported to be associated with microvascular angina.
ET-1 Binding (associated) of in plasma associated with angina and microvascular angina
1) Confidence 0.43 Published 2005 Journal Hypertens. Res. Section Abstract Doc Link 16555580 Disease Relevance 1.08 Pain Relevance 0.55
Our findings may lead to a new strategy to treat pain associated with endothelin-1.
endothelin-1 Binding (associated) of associated with pain
2) Confidence 0.42 Published 2006 Journal Neuroscience Section Abstract Doc Link 16298080 Disease Relevance 0.17 Pain Relevance 0.45
The interaction between endothelin-1 (ET-1) (5 pmol/mouse, i.c.v.) and endothelin-3 (ET-3) (5 pmol/mouse, i.c.v.) with NG-nitro-L-arginine methyl ester (L-NAME) (5 mg/kg i.p., 30 min pretreatment) was investigated in mice by the use of two experimental procedures: hot plate and tail flick tests in mice.
ET-1 Binding (interaction) of in tail associated with tail-flick
3) Confidence 0.37 Published 1994 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 7837829 Disease Relevance 0 Pain Relevance 0.16
The interaction between endothelin-1 (ET-1) (5 pmol/mouse, i.c.v.) and endothelin-3 (ET-3) (5 pmol/mouse, i.c.v.) with NG-nitro-L-arginine methyl ester (L-NAME) (5 mg/kg i.p., 30 min pretreatment) was investigated in mice by the use of two experimental procedures: hot plate and tail flick tests in mice.
endothelin-1 Binding (interaction) of in tail associated with tail-flick
4) Confidence 0.37 Published 1994 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 7837829 Disease Relevance 0 Pain Relevance 0.16
In electrophysiological study, whole-cell patch-clamp recordings were performed to investigate the interaction of ET-1 and TRPV1 using human embryonic kidney 293 (HEK293) cells expressing endothelin type A receptor (ET(A)) and TRPV1.
ET-1 Binding (interaction) of in embryonic kidney
5) Confidence 0.36 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.67 Pain Relevance 0.82
The discovery of ET-1 receptor blocking agents is now recognized as a milestone in the treatment of this latter disease.
ET-1 receptor Binding (recognized) of associated with disease
6) Confidence 0.36 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.84 Pain Relevance 0
Since ET-1 has been shown to be associated with the apoptosis of endothelial cells [17] and, similarly to hyperoxia, it also induces a parenchymal function impairment [7,11,18], the involvement of this peptide in the pathogenesis of hyperoxia-induced lung injury may be anticipated.
ET-1 Binding (associated) of in lung associated with lung injury, hyperoxia and apoptosis
7) Confidence 0.36 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 1.42 Pain Relevance 0
Cardiopulmonary bypass is thought to injure all endothelial cells, mainly by cell-to-cell interaction with activated granulocytes which, augmented by endothelin-1 (ET-1), enhance the generation of superoxide radicals.
ET-1 Binding (interaction) of in endothelial cells
8) Confidence 0.32 Published 1996 Journal Cardiovasc Surg Section Abstract Doc Link 9013015 Disease Relevance 0.09 Pain Relevance 0
We reported in 2004 that inhibition of endothelin-converting enzyme-1 (ECE-1), which colocalizes with ET-1 in the placenta [66], controls PTD in a mouse model of infection-associated PTL [67].
ET-1 Binding (colocalizes) of in placenta associated with pre-term labor and infection
9) Confidence 0.23 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.66 Pain Relevance 0.16
Vasoconstrictors include endothelin-1 (ET-1), angiotensin II (Ang II), thromboxane A2 (TXA2), and reactive oxygen species (ROS).
ET-1 Binding (include) of
10) Confidence 0.13 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.92 Pain Relevance 0.09
Vasoconstrictors include endothelin-1 (ET-1), angiotensin II (Ang II), thromboxane A2 (TXA2), and reactive oxygen species (ROS).
endothelin-1 Binding (include) of
11) Confidence 0.13 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.92 Pain Relevance 0.09
ET-1 is a potent vasoconstrictor peptide that binds to specific G protein-coupled receptors on SMCs to reverse the response to NO.
ET-1 Binding (binds) of
12) Confidence 0.13 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.87 Pain Relevance 0
Moreover the investigators measured plasma concentrations of ET-1, soluble intercellular adhesion molecule (sICAM), and soluble vascular cell adhesion molecule (sVCAM), as indicators of endothelial cells activation.
ET-1 Binding (concentrations) of in endothelial cells associated with adhesions
13) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 1.24 Pain Relevance 0.03
Figure 2 displays the estimated association of the prohormones proADM and proET1 with the risk of serious complications and death, respectively.


proET1 Binding (association) of associated with death
14) Confidence 0.07 Published 2010 Journal Crit Care Section Body Doc Link PMC2911752 Disease Relevance 0.37 Pain Relevance 0
The univariate association between the two most predictive biomarkers, proADM and proET1, respectively, and the risk of a serious complication and death, respectively, was also estimated using a generalized additive model.
proET1 Binding (association) of associated with death
15) Confidence 0.06 Published 2010 Journal Crit Care Section Body Doc Link PMC2911752 Disease Relevance 0.40 Pain Relevance 0.03
Endothelin-1 (ET-1) seems to be associated with coronary vasospasm in variant angina, suggesting that ET-1 gene variants may be important in coronary vasospasm in variant angina.
ET-1 Binding (associated) of associated with angina and coronary vasospasm
16) Confidence 0.04 Published 2008 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 19012521 Disease Relevance 0.65 Pain Relevance 0.45
ET-1 is very unstable and measuring its levels can be problematic due to binding with receptors and other proteins.
ET-1 Binding (binding) of
17) Confidence 0.03 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 1.36 Pain Relevance 0

General Comments

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