INT5338

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Context Info
Confidence 0.62
First Reported 1986
Last Reported 2010
Negated 24
Speculated 9
Reported most in Abstract
Documents 92
Total Number 101
Disease Relevance 25.54
Pain Relevance 51.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
plasma 6
neurons 5
nerve 5
hypothalamus 4
arcuate nucleus 4
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 260 100.00 Very High Very High Very High
Enkephalin 91 100.00 Very High Very High Very High
Somatostatin 53 100.00 Very High Very High Very High
narcan 38 100.00 Very High Very High Very High
substance P 35 100.00 Very High Very High Very High
Catecholamine 30 100.00 Very High Very High Very High
Morphine 28 100.00 Very High Very High Very High
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
Pain 16 100.00 Very High Very High Very High
Spinal cord 14 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 228 100.00 Very High Very High Very High
Injury 26 100.00 Very High Very High Very High
Nervous System Injury 17 100.00 Very High Very High Very High
Stress 42 99.84 Very High Very High Very High
Myocardial Infarction 30 99.84 Very High Very High Very High
Aging 7 99.84 Very High Very High Very High
Ganglion Cysts 17 99.76 Very High Very High Very High
Arthritis 9 98.96 Very High Very High Very High
INFLAMMATION 9 98.92 Very High Very High Very High
Bordatella Infection 2 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the gene regulation of NPY and agouti-related peptide (AGRP), another orexigenic peptide synthesized in the NPY neurons, in the arcuate nucleus by ghrelin in hypothalamic organotypic cultures.
Spec (examined) Regulation (regulation) of NPY in arcuate nucleus
1) Confidence 0.62 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.16
Plasma NPY and catecholamines levels were not affected by surgery at any time.
Neg (not) Regulation (affected) of NPY in Plasma associated with catecholamine
2) Confidence 0.61 Published 2000 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10737672 Disease Relevance 0 Pain Relevance 0.84
Pretreatment with capsaicin did not affect the increased level of NPY-LI in the ankle joint of arthritic rats.
Neg (not) Regulation (affect) of NPY in ankle joint associated with qutenza and arthritis
3) Confidence 0.60 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7566511 Disease Relevance 0.79 Pain Relevance 0.76
These findings indicate that adrenal NPY and enkephalin are not regulated identically.
Neg (not) Regulation (regulated) of NPY associated with enkephalin
4) Confidence 0.60 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7861161 Disease Relevance 0 Pain Relevance 0.43
Half of the animals were given ad libitum access to food whereas the other half of the animals were food-deprived. 2-DG increased food intake fourfold compared to saline injected animals, but did not affect NPY mRNA levels after 2 h.
Neg (not) Regulation (affect) of NPY
5) Confidence 0.58 Published 1998 Journal Brain Res. Section Abstract Doc Link 9593862 Disease Relevance 0.18 Pain Relevance 0.24
In rats pretreated with I.P. atropine and alpha- and beta-adrenoceptor blocking agents, the total amounts of VIP and substance P were reduced after feeding by 23 and 42%, respectively; in contrast the NPY content was not significantly affected.
Neg (not) Regulation (affected) of NPY associated with substance p
6) Confidence 0.55 Published 1996 Journal Exp. Physiol. Section Abstract Doc Link 8845143 Disease Relevance 0 Pain Relevance 0.41
Evidence is also presented for the existence of a glucocorticoid regulation of NPY IR neurons, especially of those innervating the locus coeruleus, since after 2 weeks adrenalectomy reduced NPY IR in this area.
Regulation (regulation) of NPY IR in neurons associated with locus ceruleus
7) Confidence 0.47 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455156 Disease Relevance 0.08 Pain Relevance 0.35
Enk and NPY immunoreactivity in the anterior and posterior horns was not affected by root transection up to 24 weeks postoperative.
Regulation (immunoreactivity) of NPY in anterior associated with enkephalin
8) Confidence 0.47 Published 1992 Journal J. Comp. Neurol. Section Abstract Doc Link 1377201 Disease Relevance 0 Pain Relevance 0.45
On the other hand, the hypothalamic content of NPY was unaffected in early postnatal period in newborn males as well as in females.
Neg (unaffected) Regulation (unaffected) of NPY
9) Confidence 0.45 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8829146 Disease Relevance 0.05 Pain Relevance 0.46
NPY tissue levels did not change whatever the anesthetic used.
Neg (not) Regulation (change) of NPY
10) Confidence 0.45 Published 1992 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 1604044 Disease Relevance 0 Pain Relevance 0.53
In conclusion, the orexigenic effect of the peptides orexin A, NPY and ghrelin decreased in old rats, and this reduction may have been responsible for the age-related decrease in food intake.
Regulation (effect) of NPY
11) Confidence 0.45 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16721031 Disease Relevance 0 Pain Relevance 0.21
We examined the contribution of NPY to sympathetically mediated alterations in kidney function in normal and heart failure rats.
Spec (examined) Regulation (contribution) of NPY in kidney associated with myocardial infarction
12) Confidence 0.45 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11477379 Disease Relevance 0.65 Pain Relevance 0.13
In addition, we also present the more recent data describing the other possible roles for NPY-NPY agonists and antagonists may be useful in the treatment of conditions as varied as anorexia, epilepsy, anxiety, depression, hypertension and heart failure.
Spec (possible) Regulation (roles) of NPY-NPY in heart associated with epilepsy, appetite loss, depression, antagonist, hypertension, anxiety disorder, agonist and myocardial infarction
13) Confidence 0.45 Published 1996 Journal Drugs Section Abstract Doc Link 8875128 Disease Relevance 0.82 Pain Relevance 0.51
Based on experiments in the pithed guinea-pig, it is suggested that prejunctional facilitatory beta-adrenoceptors may also be involved in the regulation of the NPY release, since infusion of isoprenaline elicited a facilitation of the PNS-induced increase of plasma NPY-LI levels which could be antagonised by propranolol.
Regulation (regulation) of NPY in plasma
14) Confidence 0.45 Published 1989 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.34
Because a subpopulation of neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (Arc) projects to the PVN, we measured NPY and POMC mRNA expression in the Arc using in situ hybridization histochemistry at several time points following daily administration of four different antidepressant drugs.
Regulation (subpopulation) of neuropeptide Y in neurons associated with antidepressant, aids-related complex and neuropeptide
15) Confidence 0.45 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.37 Pain Relevance 0.26
This suggests a possible involvement of NPY and Gal in the regulation of sympathetic nerve activity in medulla oblongata.
Spec (possible) Regulation (involvement) of NPY in nerve associated with medulla
16) Confidence 0.45 Published 1990 Journal Am. J. Hypertens. Section Abstract Doc Link 1699553 Disease Relevance 0 Pain Relevance 0.70
In the pair-fed group, NPY mRNA levels did not change, but the POMC levels decreased (compared with the vehicle controls).
Neg (not) Regulation (change) of NPY
17) Confidence 0.45 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.68 Pain Relevance 0.93
To examine further the relationship between the NAL-induced increase in LH release and increase in NPY gene expression, the effects of NPY mRNA antisense oligonucleotides (oligos) on NPY levels in the ME-ARC and on plasma LH levels were studied in NAL-infused rats.
Regulation (effects) of NPY in plasma associated with aids-related complex and narcan
18) Confidence 0.44 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.27 Pain Relevance 0.63
Taken together, our results demonstrate that the activation of ERK and p38 and also the changes in NPY and BDNF expression may occur in different populations of DRG neurons after CCI, partially through alterations in the target-derived NGF.
Regulation (changes) of NPY in neurons associated with dorsal root ganglion, nerve growth factor and eae
19) Confidence 0.44 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579142 Disease Relevance 1.29 Pain Relevance 1.10
Cysteamine did not seem to affect enkephalin-LI, NPY-LI or an epitope in SOM neurons reacting with DYN(1-13) antiserum.
Regulation (affect) of NPY in neurons associated with dynorphin, somatostatin and enkephalin
20) Confidence 0.44 Published 1987 Journal Peptides Section Abstract Doc Link 2884649 Disease Relevance 0 Pain Relevance 1.01

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