INT53385

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 26
Total Number 29
Disease Relevance 9.18
Pain Relevance 26.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (fosB) DNA binding (fosB)
Anatomy Link Frequency
PVN 16
lateral areas 5
medial 4
spinal cord 3
nucleus accumbens 2
fosB (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 140 100.00 Very High Very High Very High
cocaine 50 100.00 Very High Very High Very High
Dopamine 44 99.84 Very High Very High Very High
withdrawal 82 99.78 Very High Very High Very High
Nucleus accumbens 47 99.68 Very High Very High Very High
Sciatic nerve 5 99.68 Very High Very High Very High
addiction 90 99.48 Very High Very High Very High
opiate 7 99.36 Very High Very High Very High
c fibre 20 99.26 Very High Very High Very High
Thalamus 36 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 37 99.76 Very High Very High Very High
Morphine Dependence 26 99.48 Very High Very High Very High
Injury 7 97.92 Very High Very High Very High
Cannabis Dependence 3 97.12 Very High Very High Very High
Drug Dependence 49 96.28 Very High Very High Very High
Disease 9 96.24 Very High Very High Very High
Recurrence 16 95.76 Very High Very High Very High
Opiate Addiction 25 95.44 Very High Very High Very High
Targeted Disruption 18 83.00 Quite High
Repression 4 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, sensitized D-rats showed a selective and significant increase in FosB expression in the nucleus accumbens (core and shell), basolateral amygdala and medial prefrontal cortex, brain areas that are functionally related to the rewarding neural circuit.
Positive_regulation (increase) of Gene_expression (expression) of FosB in medial associated with nucleus accumbens and amygdala
1) Confidence 0.70 Published 2007 Journal Neuroscience Section Abstract Doc Link 17935891 Disease Relevance 0.07 Pain Relevance 0.67
These results demonstrate that a deficient nutritional status during the perinatal period results in adult subjects having neural alterations, leading to an increased responsiveness to morphine and/or enhanced reinforcement effects, which correlates with an overexpression of FosB in selective brain areas related to the rewarding network.
Positive_regulation (overexpression) of Gene_expression (overexpression) of FosB in brain associated with morphine
2) Confidence 0.70 Published 2007 Journal Neuroscience Section Abstract Doc Link 17935891 Disease Relevance 0 Pain Relevance 0.59
The present data provide the first demonstration that L-DOPA maintains high striatal levels of fosB and prodynorphin gene expression during a prolonged course of treatment, which simulates the clinical practice in Parkinson's disease more closely than the short-treatment paradigms studied thus far.
Positive_regulation (levels) of Gene_expression (expression) of fosB associated with disease
3) Confidence 0.65 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11683909 Disease Relevance 0.37 Pain Relevance 0.07
Furthermore, agmatine inhibited the increased expression of FosB in the nucleus accumbens caused by chronic morphine.
Positive_regulation (increased) of Gene_expression (expression) of FosB in nucleus accumbens associated with nucleus accumbens and morphine
4) Confidence 0.64 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15899480 Disease Relevance 0.15 Pain Relevance 0.87
In intact rats, CREB antisense reduced both basal and cocaine-induced expression of c-Fos, FosB/DeltaFosB, and prodynorphin mRNA.
Positive_regulation (cocaine-induced) of Gene_expression (expression) of FosB associated with cocaine
5) Confidence 0.49 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11739600 Disease Relevance 0 Pain Relevance 0.34
These findings suggest that enhanced sensitivity of AA rats to morphine is related to augmented morphine-induced expression of FosB/DeltaFosB and morphine-induced reduction of pCREB levels.
Positive_regulation (induced) of Gene_expression (expression) of FosB associated with morphine
6) Confidence 0.49 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 1.04
Restraint stress also significantly increased (P < 0.05) expression of the immediate early genes c-Fos and FosB within the hypothalamic PVN to a similar extent in CCI and sham rats.
Positive_regulation (increased) of Gene_expression (expression) of FosB associated with stress and eae
7) Confidence 0.44 Published 2005 Journal Brain Res. Section Abstract Doc Link 15885220 Disease Relevance 1.68 Pain Relevance 1.02
In the lateral thalamus the repeated stimulation again failed to induce c-Fos, but the expressions of FosB, c-Jun and Krox-24 were increased, and that of JunD was again reduced.
Positive_regulation (increased) of Gene_expression (expressions) of FosB in lateral associated with thalamus
8) Confidence 0.43 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0.08 Pain Relevance 0.57
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of FosB in lateral areas associated with c fibre
9) Confidence 0.43 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.73
An intense input produced by electrical stimulation of all the C-fibers in one sciatic nerve also failed to induce expression of c-Fos, FosB, Krox-20 or Krox-24 in the medial or lateral areas.
Neg (failed) Positive_regulation (induce) of Gene_expression (expression) of FosB in lateral areas associated with c fibre and sciatic nerve
10) Confidence 0.43 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.78
These findings suggest that enhanced sensitivity of AA rats to morphine is related to augmented morphine-induced expression of FosB/DeltaFosB and morphine-induced reduction of pCREB levels.
Positive_regulation (augmented) of Gene_expression (expression) of DeltaFosB associated with morphine
11) Confidence 0.41 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 1.05
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (labelling) of FosB/DeltaFosB in PVN associated with addiction, withdrawal and morphine
12) Confidence 0.37 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.46 Pain Relevance 1.19
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (labelling) of FosB/DeltaFosB in PVN associated with addiction, withdrawal and morphine
13) Confidence 0.37 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.46 Pain Relevance 1.19
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (labelling) of FosB/DeltaFosB in PVN associated with addiction, withdrawal and morphine
14) Confidence 0.37 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.46 Pain Relevance 1.19
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (expression) of FosB/DeltaFosB in PVN associated with addiction, withdrawal and morphine
15) Confidence 0.37 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.46 Pain Relevance 1.18
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (labelling) of FosB/DeltaFosB in PVN associated with addiction, withdrawal and morphine
16) Confidence 0.37 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.46 Pain Relevance 1.18
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (expression) of FosB/DeltaFosB in PVN associated with addiction, withdrawal and morphine
17) Confidence 0.37 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.46 Pain Relevance 1.20
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (expression) of FosB/DeltaFosB in PVN associated with addiction, withdrawal and morphine
18) Confidence 0.37 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.46 Pain Relevance 1.20
Morphine dependence and withdrawal evoked an increase in FosB/DeltaFosB-TH and FosB/DeltaFosB-CRF double labelling in NTS-A(2) and PVN, respectively, besides an increase in TH levels in NTS-A(2) and CRF expression in PVN.
Positive_regulation (increase) of Gene_expression (expression) of FosB/DeltaFosB in PVN associated with addiction, withdrawal and morphine
19) Confidence 0.37 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.46 Pain Relevance 1.19
These findings suggest that enhanced sensitivity of AA rats to morphine is related to augmented morphine-induced expression of FosB/DeltaFosB and morphine-induced reduction of pCREB levels.
Positive_regulation (induced) of Gene_expression (expression) of DeltaFosB associated with morphine
20) Confidence 0.28 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19324071 Disease Relevance 0 Pain Relevance 1.04

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