INT53386

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Context Info
Confidence 0.32
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.13
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp4a10) endoplasmic reticulum (Cyp4a10)
Anatomy Link Frequency
liver 1
kidney 1
Cyp4a10 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 4 89.96 High High
opiate 1 84.44 Quite High
algil 4 75.00 Quite High
Inflammation 38 62.36 Quite High
agonist 18 57.68 Quite High
chemokine 2 50.72 Quite High
cytokine 2 50.28 Quite High
addiction 4 50.00 Quite Low
vincristine 12 41.40 Quite Low
opioid receptor 1 38.40 Quite Low
Disease Link Frequency Relevance Heat
Shock 302 99.44 Very High Very High Very High
Sarcoma 166 97.68 Very High Very High Very High
Toxicity 17 96.48 Very High Very High Very High
Lymphatic System Cancer 4 95.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 68 92.80 High High
Sprains And Strains 24 82.96 Quite High
Muscle Disease 2 82.20 Quite High
Rhabdomyolysis 1 80.24 Quite High
Corneal Neovascularization 2 79.84 Quite High
Renal Failure 1 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreases in triglyceride levels in wild-type mice 24 hrs after HS cannot be explained by the decreases in ACO and Cyp4a in liver and kidney.
Negative_regulation (decreases) of Cyp4a in kidney associated with shock
1) Confidence 0.32 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.87 Pain Relevance 0
The decreases in triglyceride levels in wild-type mice 24 hrs after HS cannot be explained by the decreases in ACO and Cyp4a in liver and kidney.
Negative_regulation (decreases) of Cyp4a in liver associated with shock
2) Confidence 0.11 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.87 Pain Relevance 0
HET0016, a selective inhibitor of CYP4A, suppresses the formation of 20-HETE at a concentration <10 nM, and has no effect on epoxygenase, cyclooxygenase, or lipoxygenase activity at concentrations up to 1 ?
Negative_regulation (inhibitor) of CYP4A
3) Confidence 0.09 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.39 Pain Relevance 0.17
Protease inhibitors are known to block the activity of cytochrome p450IIIA4 (CYP3A4), which metabolizes anthracycline drugs (von Moltke et al 1998).
Negative_regulation (block) of CYP3A4
4) Confidence 0.01 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.80 Pain Relevance 0
Protease inhibitors are known to block the activity of cytochrome p450IIIA4 (CYP3A4), which metabolizes anthracycline drugs (von Moltke et al 1998).
Negative_regulation (block) of cytochrome p450IIIA4
5) Confidence 0.01 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.79 Pain Relevance 0
Many drugs that are potent inhibitors of CYP3A4 can increase the risk of myopa-thy by reducing the elimination of simvastatin.
Negative_regulation (inhibitors) of CYP3A4
6) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.41 Pain Relevance 0
In addition, other enzymes from the CYP2C, CYP3A, and CYP4A gene families were also suppressed, whereas CYP1A2, CYP2B1, and CYP2E1 were induced.
Negative_regulation (suppressed) of CYP4A gene
7) Confidence 0.01 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7838134 Disease Relevance 0 Pain Relevance 0.53

General Comments

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