INT5339

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 4.50
Pain Relevance 8.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
plasma 2
arcuate nucleus 2
Sciatic nerve 2
neurons 2
basket cells 2
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 66 100.00 Very High Very High Very High
Potency 3 99.96 Very High Very High Very High
narcan 14 99.94 Very High Very High Very High
Sciatic nerve 13 99.80 Very High Very High Very High
antagonist 7 99.64 Very High Very High Very High
opioid receptor 5 99.42 Very High Very High Very High
fluoxetine 7 99.26 Very High Very High Very High
substance P 15 98.80 Very High Very High Very High
dorsal root ganglion 8 98.80 Very High Very High Very High
Endogenous opioid 3 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 9 99.98 Very High Very High Very High
Eating Disorder 1 99.32 Very High Very High Very High
Ganglion Cysts 9 98.80 Very High Very High Very High
Middle Cerebral Artery Infarction 3 98.72 Very High Very High Very High
Neuropathic Pain 20 98.02 Very High Very High Very High
Appetite Loss 1 97.52 Very High Very High Very High
Stress 2 97.16 Very High Very High Very High
Lordosis 6 95.00 High High
Injury 17 94.48 High High
Convulsion 5 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have reported previously that blockade of EOP influence by the opioid receptor antagonist, naloxone (NAL), stimulated NPY accumulation in the median eminence (ME) in association with increased LH release in estradiol-17 beta-primed ovariectomized rats.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of NPY in median eminence associated with antagonist, narcan and opioid receptor
1) Confidence 0.68 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0 Pain Relevance 0.54
These results indicate that stimulation of the NPY receptors and alpha-adrenoceptors in the nTS region may cause inhibition of the adenylate cyclase.
Spec (may) Positive_regulation (cause) of Positive_regulation (stimulation) of NPY
2) Confidence 0.49 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3035437 Disease Relevance 0 Pain Relevance 0.31
Enhanced concentrations of NPY mRNA were observed in interneurons of the hilus, including presumptive fusiform neurons and pyramidal-shaped basket cells already 4 hours after initiation of limbic seizures by KA (10 mg/kg, i.p.).
Positive_regulation (Enhanced) of Positive_regulation (concentrations) of NPY in basket cells associated with convulsion
3) Confidence 0.47 Published 1994 Journal Hippocampus Section Abstract Doc Link 7874238 Disease Relevance 0.31 Pain Relevance 0.05
Pretreatment with 1 mg/kg reserpine for 48 h induced a 6-fold increase in NPY potency.
Positive_regulation (induced) of Positive_regulation (increase) of NPY associated with potency
4) Confidence 0.47 Published 1985 Journal Neurosci. Lett. Section Abstract Doc Link 2997668 Disease Relevance 0 Pain Relevance 0.33
To determine whether NPY and endogenous opioids interact, we tested the hypothesis that estrogen-induced MOR activation is mediated through NPY-Y1 receptor (Y1R) activation.
Positive_regulation (mediated) of Positive_regulation (activation) of NPY associated with endogenous opioid
5) Confidence 0.46 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.10 Pain Relevance 0.43
Diazepam reduced this stimulation-induced increase of plasma NPY-IR in a dose-dependent manner.
Positive_regulation (stimulation-induced) of Positive_regulation (increase) of plasma NPY-IR in plasma
6) Confidence 0.44 Published 1992 Journal Ma Zui Xue Za Zhi Section Abstract Doc Link 1302786 Disease Relevance 0.26 Pain Relevance 0.78
Estrogen-induced mu-opioid receptor internalization in the medial preoptic nucleus is mediated via neuropeptide Y-Y1 receptor activation in the arcuate nucleus of female rats.
Positive_regulation (mediated) of Positive_regulation (activation) of neuropeptide Y in arcuate nucleus associated with neuropeptide and opioid receptor
7) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Title Doc Link 14749439 Disease Relevance 0.08 Pain Relevance 0.41
Thus PSNL induces NPY up-regulation in spared as well as injured DRG neurons, both contribute to the increased NPY immunoreactivity in the gracile nucleus in the middle-aged rats.
Positive_regulation (induces) of Positive_regulation (up-regulation) of NPY in gracile nucleus associated with dorsal root ganglion
8) Confidence 0.41 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10797555 Disease Relevance 0.75 Pain Relevance 0.71
Furthermore, seven days fluoxetine treatment prevented the significant increases in hypothalamic neuropeptide Y messenger RNA which were induced in lean rats by food restriction which precisely matched the hypophagia induced by the drug.
Positive_regulation (induced) of Positive_regulation (increases) of neuropeptide Y associated with appetite loss, neuropeptide, eating disorder and fluoxetine
9) Confidence 0.41 Published 1996 Journal Neuroscience Section Abstract Doc Link 8737424 Disease Relevance 0.49 Pain Relevance 1.15
Injection of colchicine enhanced the periinfarct increase in neuropeptide Y but did not alter the increase in tyrosine hydroxylase.
Neg (not) Positive_regulation (enhanced) of Positive_regulation (increase) of neuropeptide Y associated with neuropeptide
10) Confidence 0.27 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9331169 Disease Relevance 0.63 Pain Relevance 0.62
In vivo administration of aFGF counteracted the axotomy-induced increase in galanin and NPY, whereas bFGF only suppressed NPY upregulation.
Positive_regulation (axotomy-induced) of Positive_regulation (increase) of NPY
11) Confidence 0.23 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8916273 Disease Relevance 0.17 Pain Relevance 0.80
Sciatic nerve transection induced a distinct increase in galanin- and NPY-LIs, but a downregulation of substance P-LI.
Positive_regulation (induced) of Positive_regulation (increase) of NPY in Sciatic nerve associated with sciatic nerve and substance p
12) Confidence 0.21 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8916273 Disease Relevance 0.16 Pain Relevance 0.67
Partial and complete sciatic nerve injuries induce similar increases of neuropeptide Y and vasoactive intestinal peptide immunoreactivities in primary sensory neurons and their central projections.
Positive_regulation (induce) of Positive_regulation (increases) of neuropeptide Y in primary sensory neurons associated with nervous system injury, neuropeptide and sciatic nerve
13) Confidence 0.21 Published 1998 Journal Neuroscience Section Title Doc Link 9697128 Disease Relevance 0.83 Pain Relevance 0.71
Furthermore, in a model of neuropathic pain induced by chronic constriction of the sciatic nerve, ERK phosphorylation in the DRG was shown to lead to increases in the levels of neuropeptide Y (NPY) in damaged neurons [81].
Positive_regulation (lead) of Positive_regulation (increases) of neuropeptide Y in neurons associated with neuropeptide, neuropathic pain and sciatic nerve
14) Confidence 0.08 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644492 Disease Relevance 0.73 Pain Relevance 0.66

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