INT53390

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Context Info
Confidence 0.35
First Reported 1995
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 10 99.84 Very High Very High Very High
sSRI 16 96.96 Very High Very High Very High
antidepressant 4 94.24 High High
Morphine 4 88.76 High High
opiate 1 83.24 Quite High
algil 4 75.00 Quite High
opioid receptor 1 42.32 Quite Low
depression 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, other enzymes from the CYP2C, CYP3A, and CYP4A gene families were also suppressed, whereas CYP1A2, CYP2B1, and CYP2E1 were induced.
Negative_regulation (suppressed) of Positive_regulation (induced) of CYP1A2
1) Confidence 0.35 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7838134 Disease Relevance 0 Pain Relevance 0.54
Fluvoxamine is a potent CYP1A2 and CYP2C19 inhibitor, and a moderate CYP2C9, CYP2D6, and CYP3A4 inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (potent) of CYP1A2
2) Confidence 0.07 Published 2002 Journal Curr. Drug Metab. Section Abstract Doc Link 11876575 Disease Relevance 0 Pain Relevance 0.74
Fluvoxamine is a potent CYP1A2 and CYP2C19 inhibitor, and a moderate CYP2C9, CYP2D6, and CYP3A4 inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (potent) of CYP1A2
3) Confidence 0.07 Published 2002 Journal Curr. Drug Metab. Section Abstract Doc Link 11876575 Disease Relevance 0 Pain Relevance 0.76

General Comments

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