INT5340

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Context Info
Confidence 0.55
First Reported 1986
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.83
Pain Relevance 8.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
plasma 4
hypothalamus 2
sympathetic 2
interneurons 2
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 49 100.00 Very High Very High Very High
Enkephalin 13 100.00 Very High Very High Very High
Catecholamine 4 100.00 Very High Very High Very High
noradrenaline 4 100.00 Very High Very High Very High
withdrawal 2 100.00 Very High Very High Very High
antagonist 6 99.98 Very High Very High Very High
fluoxetine 18 99.84 Very High Very High Very High
algil 6 99.84 Very High Very High Very High
Pain 3 99.76 Very High Very High Very High
anticonvulsant 1 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 11 100.00 Very High Very High Very High
Convulsion 8 100.00 Very High Very High Very High
Aging 1 99.84 Very High Very High Very High
Pain 2 99.76 Very High Very High Very High
Eating Disorder 1 98.00 Very High Very High Very High
Appetite Loss 1 96.20 Very High Very High Very High
Body Weight 1 95.08 Very High Very High Very High
Anxiety Disorder 2 94.56 High High
Nociception 1 93.88 High High
Weight Gain 2 91.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anticonvulsant treatment with thiopental, after a brief period of generalized seizures, prevented the increase in NPY mRNA in granule cells but not in interneurons.
Negative_regulation (prevented) of Positive_regulation (increase) of NPY in interneurons associated with convulsion and anticonvulsant
1) Confidence 0.55 Published 1994 Journal Hippocampus Section Abstract Doc Link 7874238 Disease Relevance 0.51 Pain Relevance 0.19
Diazepam reduced this stimulation-induced increase of plasma NPY-IR in a dose-dependent manner.
Negative_regulation (reduced) of Positive_regulation (increase) of plasma NPY-IR in plasma
2) Confidence 0.51 Published 1992 Journal Ma Zui Xue Za Zhi Section Abstract Doc Link 1302786 Disease Relevance 0.27 Pain Relevance 0.78
Moreover, pain-stimulated increase of plasma NPY-IR in rats was also reduced by pethidine.
Negative_regulation (reduced) of Positive_regulation (increase) of plasma NPY-IR in plasma associated with pain and algil
3) Confidence 0.51 Published 1992 Journal Ma Zui Xue Za Zhi Section Abstract Doc Link 1302786 Disease Relevance 0.28 Pain Relevance 0.84
The reserpine-induced depletion of NPY-LI, but not that of NA, was inhibited by pretreatment with the ganglionic blocking agent chlorisondamine or the alpha 2-adrenoceptor agonist clonidine, both of which are known to decrease renal sympathetic nerve activity.
Negative_regulation (inhibited) of Positive_regulation (reserpine-induced) of NPY in sympathetic associated with agonist, noradrenaline and clonidine
4) Confidence 0.43 Published 1988 Journal Acta Physiol. Scand. Section Abstract Doc Link 3239423 Disease Relevance 0.09 Pain Relevance 0.45
RT-PCR analyses showed that mRNA expression levels of both NPY and POMC were markedly reduced by fluoxetine treatment in all parts of the brain examined, including the hypothalamus.
Negative_regulation (reduced) of Positive_regulation (levels) of NPY in hypothalamus associated with fluoxetine
5) Confidence 0.42 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.68 Pain Relevance 0.88
The reserpine-induced elevation in neuropeptide Y-like immunoreactivity at the 5-day time point was abolished in rats with a chronic bilateral splanchnectomy.
Negative_regulation (abolished) of Positive_regulation (elevation) of neuropeptide Y associated with neuropeptide
6) Confidence 0.42 Published 1986 Journal Neuroscience Section Abstract Doc Link 3540720 Disease Relevance 0.08 Pain Relevance 0.60
Pre-treatment of rats with thiopental prior to kainic acid prevented seizures, the decline in catecholamines and the elevation of enkephalin and neuropeptide Y mRNAs but not that of chromogranin B.
Negative_regulation (prevented) of Positive_regulation (elevation) of neuropeptide Y associated with convulsion, catecholamine, neuropeptide and enkephalin
7) Confidence 0.41 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9427505 Disease Relevance 0.32 Pain Relevance 0.53
Furthermore, seven days fluoxetine treatment prevented the significant increases in hypothalamic neuropeptide Y messenger RNA which were induced in lean rats by food restriction which precisely matched the hypophagia induced by the drug.
Negative_regulation (prevented) of Positive_regulation (increases) of neuropeptide Y associated with appetite loss, neuropeptide, eating disorder and fluoxetine
8) Confidence 0.38 Published 1996 Journal Neuroscience Section Abstract Doc Link 8737424 Disease Relevance 0.49 Pain Relevance 1.15
The neuropeptide Y-induced increases in hindpaw withdrawal latency were reversed by following injection of 0.42 nmol of the Y1 antagonist, NPY(28-36).
Negative_regulation (reversed) of Positive_regulation (increases) of neuropeptide Y associated with antagonist, neuropeptide and withdrawal
9) Confidence 0.37 Published 2000 Journal Regul. Pept. Section Abstract Doc Link 11062340 Disease Relevance 0.09 Pain Relevance 0.84
When given together with acetylcholinesterase antibodies, the cholinergic antagonists blocked the increase of NPY-IR but not Met-Enk-IR.
Negative_regulation (blocked) of Positive_regulation (increase) of NPY-IR associated with antagonist
10) Confidence 0.35 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7861161 Disease Relevance 0 Pain Relevance 0.49
Pre-emptive MK-801 reduced the magnitude of the increase in NPY in laminae 3-4 in the ligated group (P < 0.005) and clonidine showed a similar trend but this did not reach significance.
Negative_regulation (reduced) of Positive_regulation (increase) of NPY associated with clonidine
11) Confidence 0.35 Published 1995 Journal Pain Section Abstract Doc Link 8577486 Disease Relevance 0.24 Pain Relevance 1.20
Adrenal neuropeptide Y mRNA but not preproenkephalin mRNA induction by stress is impaired by aging in Fischer 344 rats.
Negative_regulation (impaired) of Neg (not) Positive_regulation (induction) of Adrenal neuropeptide Y mRNA associated with stress, aging, neuropeptide and enkephalin
12) Confidence 0.11 Published 1998 Journal Mech. Ageing Dev. Section Title Doc Link 9622227 Disease Relevance 0.78 Pain Relevance 0.30

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