INT53402

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Context Info
Confidence 0.75
First Reported 1995
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.13
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr7) signal transducer activity (Htr7)
Anatomy Link Frequency
neurons 2
hypothalamus 1
brain 1
astrocytes 1
dorsal root ganglia 1
Htr7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 15 99.84 Very High Very High Very High
antagonist 3 99.08 Very High Very High Very High
spastic colon 8 98.16 Very High Very High Very High
Spinal cord 9 96.56 Very High Very High Very High
Dorsal horn 9 96.08 Very High Very High Very High
fluoxetine 1 93.84 High High
agonist 4 92.60 High High
Serotonin 4 90.60 High High
abdominal pain 2 87.76 High High
Paresthesia 2 86.64 High High
Disease Link Frequency Relevance Heat
Functional Bowel Disorder 4 98.16 Very High Very High Very High
Dyskinesias 2 88.24 High High
Abdominal Pain 2 87.76 High High
Dysesthesia 2 86.64 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 85.00 Quite High
Pain 1 65.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the 5-ht7 receptor binding site is expressed in rat hypothalamus and that this receptor binding site is down-regulated after a chronic increase in the synaptic level of 5-HT.
Gene_expression (expressed) of 5-ht7 in hypothalamus
1) Confidence 0.75 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7838138 Disease Relevance 0 Pain Relevance 0.13
Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed expression of 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5B, 5-HT6 and 5-HT7 receptor mRNAs in astrocytes derived from 2-day old rats and cultured for 10-12 days.
Gene_expression (expression) of 5-HT7 in astrocytes
2) Confidence 0.75 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9795156 Disease Relevance 0 Pain Relevance 0.15
The purpose of this study was to determine whether the 5-hydroxytryptamine7 (5-HT7) receptor is expressed by nociceptor-like neurons in the rat PNS and whether 5-HT activates these nociceptors via the 5-HT7 receptor subtype.
Gene_expression (expressed) of 5-HT7 in neurons associated with nociceptor
3) Confidence 0.75 Published 2002 Journal Life Sci. Section Abstract Doc Link 12215375 Disease Relevance 0 Pain Relevance 0.34
We conclude that the 5-HT7 receptor is expressed by rat primary afferent nociceptors which terminate in the superficial layers of the spinal cord dorsal horn and that the 5-HT7 receptor subtype is involved in nociceptor activation by 5-HT.
Gene_expression (expressed) of 5-HT7 in nociceptor associated with nociceptor, dorsal horn and spinal cord
4) Confidence 0.75 Published 2002 Journal Life Sci. Section Abstract Doc Link 12215375 Disease Relevance 0 Pain Relevance 0.78
Using a polyclonal antibody and the method of immunofluorescence staining, we demonstrated that the 5-HT7 receptor appears predominately on "nociceptor-like" neurons of the rat lumbar dorsal root ganglia.
Gene_expression (appears) of 5-HT7 in neurons associated with nociceptor
5) Confidence 0.65 Published 2002 Journal Life Sci. Section Abstract Doc Link 12215375 Disease Relevance 0 Pain Relevance 0.49
Expression and role of 5-HT7 receptor in brain and intestine in rats with irritable bowel syndrome.
Gene_expression (Expression) of 5-HT7 in brain associated with spastic colon
6) Confidence 0.65 Published 2007 Journal Chin. Med. J. Section Title Doc Link 18167178 Disease Relevance 0.45 Pain Relevance 0.48
Within lumbar dorsal root ganglia, the presence of the 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3 and 5-HT7 receptor subtype messenger RNAs was detected.
Gene_expression (presence) of 5-HT7 in dorsal root ganglia
7) Confidence 0.29 Published 1996 Journal Neuroscience Section Abstract Doc Link 8848158 Disease Relevance 0.07 Pain Relevance 0.18
Expression and role of 5-HT7 receptor in brain and intestine in rats with irritable bowel syndrome.
Gene_expression (Expression) of 5-HT7 in intestine associated with spastic colon
8) Confidence 0.22 Published 2007 Journal Chin. Med. J. Section Title Doc Link 18167178 Disease Relevance 0.45 Pain Relevance 0.48

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