INT53434

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Context Info
Confidence 0.07
First Reported 1995
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.67
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (T) DNA binding (T) cytoplasm (T)
Anatomy Link Frequency
vertebral body 1
T (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 100.00 Very High Very High Very High
agonist 3 98.68 Very High Very High Very High
cva 1 97.88 Very High Very High Very High
Enkephalin 1 97.84 Very High Very High Very High
imagery 166 97.00 Very High Very High Very High
opioid receptor 8 96.92 Very High Very High Very High
Kappa opioid receptor 4 92.48 High High
epidural 50 91.96 High High
antagonist 1 87.76 High High
cytokine 8 87.20 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 54 100.00 Very High Very High Very High
Sprains And Strains 33 98.96 Very High Very High Very High
Hemorrhage 6 97.88 Very High Very High Very High
Sclerosis 8 97.56 Very High Very High Very High
Hematoma 19 96.52 Very High Very High Very High
Cancer 24 91.48 High High
Infection 3 88.80 High High
Disease 112 88.72 High High
Spinal Epidural Hematoma 23 87.48 High High
Body Weight 9 81.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, more Gd atoms are exposed to the bulk water molecules which eventually results in an enhanced T1 relaxation effect.
Positive_regulation (enhanced) of T1
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764087 Disease Relevance 0.07 Pain Relevance 0
Measurement of T1 relaxation rates for different lipid dose
Positive_regulation (Measurement) of T1
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764087 Disease Relevance 0.15 Pain Relevance 0.03
We reasoned that the full capability of liposomes to amplify signal has not been exploited and therefore tested whether liposomes that both encapsulate and display gadolinium on their surface would exhibit increased T1 relaxivity in vitro and whether this leads to further signal enhancement in vivo.
Spec (whether) Positive_regulation (increased) of T1
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764087 Disease Relevance 0.16 Pain Relevance 0.11
Whereas maximal inhibition of adenylyl cyclase activity did not correlate with receptor number among cell lines, the inhibition of cyclic AMP production did correlate with stimulation of low-Km GTPase activity.
Positive_regulation (stimulation) of low-Km GTPase
4) Confidence 0.04 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7840787 Disease Relevance 0.07 Pain Relevance 0.26
Stimulation of low-Km GTPase activity by the kappa-selective agonist (-)U50,488 was greatest in R1.G1 membranes, followed by R1EGO and R1.1.
Positive_regulation (Stimulation) of low-Km GTPase associated with agonist
5) Confidence 0.04 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7840787 Disease Relevance 0.21 Pain Relevance 0.27
The MRI features were quite specific for hemorrhage, including isointense signal on T1-weighted images, high signal on T2-weighted images in acute cases and increased signal intensity on both T1 - and T2 -weighted images in subacute cases.8-11 In a case of hyperacute stage of the hematoma, contrast-enhanced MR images may be useful.
Positive_regulation (increased) of T1 associated with hematoma, cva and imagery
6) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2688151 Disease Relevance 0.91 Pain Relevance 0.36
Review of the MRI shows some minor increased signal in the expanded L1 vertebral body on both T1 and T2 parasagittal images, suggestive of fatty marrow change (white arrows)
Positive_regulation (increased) of T1 in vertebral body
7) Confidence 0.01 Published 2007 Journal Skeletal Radiol Section Body Doc Link PMC1934928 Disease Relevance 0.71 Pain Relevance 0.06
Application of the selective delta-opioid receptor agonist, [Tyr-D-Pen-Gly-Phe-D-Pen]-enkephalin (DPDPE, 1 microM), decreased the amplitude of the field-excitatory synaptic potential and at the same time increased the paired pulse ratio (PPR) suggesting a presynaptic site of action.
Positive_regulation (increased) of ratio associated with agonist, enkephalin and opioid receptor
8) Confidence 0.01 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17197081 Disease Relevance 0 Pain Relevance 0.50
Lr32 and Ls33, previously selected for their in vitro and in vivo anti-inflammatory properties, induced very low expression levels of co-stimulation markers as compared to untreated DCs, while strong and similar up-regulation was observed for the LAB strains NCFM, MG1363 and E. coli.
Positive_regulation (regulation) of Lr32 associated with inflammation and sprains and strains
9) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.39 Pain Relevance 0.50

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