INT53447

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Context Info
Confidence 0.54
First Reported 1995
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 12.90
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLD) small molecule metabolic process (DLD) oxidoreductase activity (DLD)
aging (DLD) cellular nitrogen compound metabolic process (DLD) cytoplasm (DLD)
Anatomy Link Frequency
blood 3
LAD 2
myocardium 1
LAd 1
lymphocytes 1
DLD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 46 99.24 Very High Very High Very High
lidocaine 2 97.12 Very High Very High Very High
Paracetamol 5 96.68 Very High Very High Very High
pain pelvic 6 96.42 Very High Very High Very High
Inflammatory response 4 94.44 High High
imagery 5 93.20 High High
abdominal pain 4 91.76 High High
anesthesia 3 89.64 High High
Opioid 2 88.68 High High
Serotonin 3 85.20 High High
Disease Link Frequency Relevance Heat
American Trypanosomiasis 6 100.00 Very High Very High Very High
Pathologic Constriction 35 99.96 Very High Very High Very High
Acute Liver Failure 4 99.64 Very High Very High Very High
INFLAMMATION 50 99.42 Very High Very High Very High
Fistula 9 99.38 Very High Very High Very High
Urological Neuroanatomy 72 99.18 Very High Very High Very High
Acid Base Imbalance 4 98.32 Very High Very High Very High
Injury 76 97.52 Very High Very High Very High
Reprotox - General 3 6 96.42 Very High Very High Very High
Disease 10 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Molecular basis of lipoamide dehydrogenase deficiency in Ashkenazi Jews.
Negative_regulation (deficiency) of lipoamide dehydrogenase
1) Confidence 0.54 Published 1999 Journal Am. J. Med. Genet. Section Title Doc Link 9934985 Disease Relevance 1.00 Pain Relevance 0.09
LADH was also inactivated after incubation with MPO-generated free radicals such as the Chloropromazine and Paracetamol radicals (Table 2).
Negative_regulation (inactivated) of LADH associated with paracetamol and urological neuroanatomy
2) Confidence 0.42 Published 1998 Journal Medicina (B Aires) Section Abstract Doc Link 9706251 Disease Relevance 0.86 Pain Relevance 0.15
[Myeloperoxidase as a factor of oxidative damage of the myocardium: inactivation of dihydrolipoamide dehydrogenase].
Negative_regulation (inactivation) of dihydrolipoamide dehydrogenase in myocardium
3) Confidence 0.42 Published 1998 Journal Medicina (B Aires) Section Title Doc Link 9706251 Disease Relevance 0.63 Pain Relevance 0
We studied 13 patients with lipoamide dehydrogenase (LAD) deficiency, originating from seven Ashkenazi Jewish families.
Negative_regulation (deficiency) of lipoamide dehydrogenase
4) Confidence 0.39 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 9934985 Disease Relevance 0.84 Pain Relevance 0.09
We studied 13 patients with lipoamide dehydrogenase (LAD) deficiency, originating from seven Ashkenazi Jewish families.
Negative_regulation (deficiency) of LAD
5) Confidence 0.39 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 9934985 Disease Relevance 0.84 Pain Relevance 0.09
After the surgery, there was no remarkable decrease in blood flow in the LAD during rapid atrial pacing (130 bpm), and the preoperative reduction ratio was calculated as 24% compared with postoperatively.
Neg (no) Negative_regulation (decrease) of LAD in blood
6) Confidence 0.37 Published 1995 Journal J Cardiol Section Abstract Doc Link 8523264 Disease Relevance 0.67 Pain Relevance 0.12
Three patterns of injury/defect to the levator ani (LAd) were observed in 20/26 patients with unexplained pelvic pain: avulsion of the pubococcygeus from its origin at the pubis (LAd I, 3/20), avulsion of the pubococcygeus from its origin at the arcus tendineus levator ani (LAd II, 14/20), and, loss of shape and form of the pubococcygeus (LAd III, 6/20).
Negative_regulation (loss) of LAd in LAd associated with pain pelvic and injury
7) Confidence 0.37 Published 2007 Journal J Obstet Gynaecol Section Abstract Doc Link 18097905 Disease Relevance 0.74 Pain Relevance 0.70
In all patients LAD activity was reduced to 8 to 21% of the control in muscle or lymphocytes.
Negative_regulation (reduced) of LAD in lymphocytes
8) Confidence 0.35 Published 1999 Journal Am. J. Med. Genet. Section Abstract Doc Link 9934985 Disease Relevance 1.00 Pain Relevance 0.08
Moreover, the ratio of maximal blood flow velocity at the site of stenosis to the pre-stenotic blood flow velocity (M/P-ratio) correlated significantly with the reduction of the luminal diameter of LAD (r = 0.85, P < 0.003).
Negative_regulation (reduction) of LAD in blood associated with pathologic constriction
9) Confidence 0.31 Published 2000 Journal Clin Physiol Section Abstract Doc Link 11100389 Disease Relevance 0.92 Pain Relevance 0.19
Conformational studies provided evidence for the little disturbance of the backbone conformational equilibrium when Phe3 is replaced by (S)- or (R)-Atc.
Negative_regulation (replaced) of Phe3
10) Confidence 0.10 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9083489 Disease Relevance 0 Pain Relevance 0.19
During angiographic follow-up an increase of the size of the fistula was observed, together with a reduction of that of distal LAD.
Negative_regulation (reduction) of LAD in LAD associated with fistula
11) Confidence 0.06 Published 1995 Journal G Ital Cardiol Section Abstract Doc Link 8682233 Disease Relevance 0.91 Pain Relevance 0.14
The EC LAD clearly decreased the blood levels of the two drugs and significantly generated diazepam and lidocaine metabolites indicating the maintenance of active P450 forms in the cellular component of the devices.
Negative_regulation (decreased) of LAD in blood associated with lidocaine
12) Confidence 0.06 Published 1995 Journal Hepatology Section Abstract Doc Link 7843721 Disease Relevance 0.33 Pain Relevance 0.19
Dihydrolipoamide dehydrogenase (LADH) from Trypanosoma cruzi was inactivated by treatment with myeloperoxidase (MPO)-dependent systems.
Negative_regulation (inactivated) of Dihydrolipoamide dehydrogenase associated with american trypanosomiasis and urological neuroanatomy
13) Confidence 0.06 Published 2000 Journal Free Radic. Res. Section Abstract Doc Link 10826917 Disease Relevance 0.57 Pain Relevance 0
Comparison of the above effects and those previously reported with pig myocardial LADH indicates that both enzymes were similarly affected by the MPO-dependent systems, allowance being made for T. cruzi LADH diaphorase inactivation and the greater sensitivity of its LADH lipoamide reductase activity towards the MPO/H2O2/NaCl system and NaOCl.
Negative_regulation (inactivation) of LADH diaphorase associated with urological neuroanatomy
14) Confidence 0.06 Published 2000 Journal Free Radic. Res. Section Abstract Doc Link 10826917 Disease Relevance 1.13 Pain Relevance 0.13
With MPO/H2O2/NaCl, LADH lipoamide reductase and diaphorase activities significantly decreased as a function of incubation time.
Negative_regulation (decreased) of diaphorase associated with urological neuroanatomy
15) Confidence 0.05 Published 2000 Journal Free Radic. Res. Section Abstract Doc Link 10826917 Disease Relevance 0.78 Pain Relevance 0
However, the consistency of the variations observed across artery types, as well as the associated reduced inflammatory reaction, suggested the observed 12% decrease in LAD stenosis is related to treatment with ELN 457946.


Negative_regulation (decrease) of LAD in artery associated with pathologic constriction and inflammation
16) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001476 Disease Relevance 0.88 Pain Relevance 0.05
This decrease did not reach statistical significance but was consistent with effects on other morphometric measurements, suggesting this decrease in LAD neointimal response was the result of treatment with ELN 457946.
Negative_regulation (decrease) of LAD
17) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001476 Disease Relevance 0.71 Pain Relevance 0.18
Mutations in the genes for the other subunits have all been described, but only dihydrolipoamide dehydrogenase (E3) and E3 binding protein (E3BP) defects contribute significantly to the total number of patients with PDH deficiency.
Negative_regulation (defects) of dihydrolipoamide dehydrogenase
18) Confidence 0.02 Published 2006 Journal Dev Med Child Neurol Section Abstract Doc Link 16904023 Disease Relevance 0.09 Pain Relevance 0.09

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