INT53448

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.71
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 34 99.48 Very High Very High Very High
antagonist 2 93.40 High High
Pyramidal cell 1 92.36 High High
Hippocampus 3 91.64 High High
agonist 3 87.96 High High
Analgesic 2 75.16 Quite High
fortral 1 57.28 Quite High
Disease Link Frequency Relevance Heat
Injury 10 81.04 Quite High
Death 2 79.32 Quite High
Necrosis 2 78.04 Quite High
Hepatotoxicity 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, following high doses of SKF-525A or PB, sufficient to induce a complete inactivation of cytochromes P-450, DTG still potentiated the NMDA response.
Positive_regulation (induce) of Negative_regulation (inactivation) of P-450
1) Confidence 0.58 Published 1993 Journal Synapse Section Abstract Doc Link 8427011 Disease Relevance 0 Pain Relevance 0.41
A 30% decrease in cytochromes P-450 induced by cobalt chloride failed to provide protection against APAP lethality.
Positive_regulation (induced) of Negative_regulation (decrease) of cytochromes P-450 associated with paracetamol
2) Confidence 0.23 Published 1995 Journal Hepatology Section Abstract Doc Link 7843722 Disease Relevance 0.36 Pain Relevance 1.07
Because TA caused a 23% decrease of hepatic microsomal cytochromes P-450, the possibility that TA protection may be caused by decreased bioactivation of APAP was examined.
Positive_regulation (caused) of Negative_regulation (decrease) of cytochromes P-450 associated with paracetamol
3) Confidence 0.20 Published 1995 Journal Hepatology Section Abstract Doc Link 7843722 Disease Relevance 0.34 Pain Relevance 0.95

General Comments

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