INT5345

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 6.72
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BRD2)
Anatomy Link Frequency
plasma 2
Blood 1
pituitary 1
pinealocytes 1
BRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 23 98.52 Very High Very High Very High
opioid receptor 3 96.92 Very High Very High Very High
dexamethasone 2 96.76 Very High Very High Very High
Analgesic 4 96.72 Very High Very High Very High
butorphanol 3 96.32 Very High Very High Very High
antagonist 4 94.32 High High
opiate 6 93.88 High High
headache 5 89.80 High High
mu opioid receptor 2 89.04 High High
imagery 1 88.72 High High
Disease Link Frequency Relevance Heat
Oligospermia 2 99.88 Very High Very High Very High
Disease 12 99.84 Very High Very High Very High
Reprotox - General 1 10 99.44 Very High Very High Very High
Polycystic Ovary Syndrome 19 99.40 Very High Very High Very High
Frailty 1 98.84 Very High Very High Very High
Stress 3 98.42 Very High Very High Very High
Mumps 89 98.30 Very High Very High Very High
Hyperandrogenism 3 97.76 Very High Very High Very High
Brain Injury 2 96.68 Very High Very High Very High
Hypoglycemia 7 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant increase in FSH (p < 0.001) was only observed during GnRH, GnRH + naloxone and GnRH + aMSH tests (AUCs: placebo 13.3 +/- 1.7; naloxone 14.7 +/- 2.5; alpha-MSH 15.5 +/- 2.3; alpha-MSH + naloxone 16.9 +/- 1.9; GnRH 19.1 +/- 1.1; GnRH + alpha-MSH 20.7 +/- 1.3; GnRH + naloxone 21.2 +/- 1.8 mIU/ml.min-1).
Positive_regulation (increase) of FSH associated with narcan
1) Confidence 0.67 Published 1997 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9211127 Disease Relevance 0 Pain Relevance 0.71
There is an increase in mean LH levels and of the LH/FSH ratio with increasing severity of the ovarian disturbance.
Positive_regulation (increase) of FSH
2) Confidence 0.67 Published 1987 Journal Horm. Res. Section Abstract Doc Link 3454343 Disease Relevance 0.37 Pain Relevance 0.31
The child had also elevated basal plasma FSH (36 microU/ml) and LH (5 microU/ml) with further elevation to the peak of 123 and 99 microU/ml respectively after LHRH stimulation.
Positive_regulation (elevated) of FSH in plasma
3) Confidence 0.67 Published 1993 Journal J Med Assoc Thai Section Abstract Doc Link 7823001 Disease Relevance 0.37 Pain Relevance 0.12
Blood LH level and the LH/FSH ratio significantly reduced in those in whom these values were elevated in disease.
Positive_regulation (elevated) of FSH in Blood associated with disease
4) Confidence 0.45 Published 1992 Journal Probl Endokrinol (Mosk) Section Abstract Doc Link 1302841 Disease Relevance 0.69 Pain Relevance 0.09
The child had also elevated basal plasma FSH (36 microU/ml) and LH (5 microU/ml) with further elevation to the peak of 123 and 99 microU/ml respectively after LHRH stimulation.
Positive_regulation (elevation) of FSH in plasma
5) Confidence 0.45 Published 1993 Journal J Med Assoc Thai Section Abstract Doc Link 7823001 Disease Relevance 0.37 Pain Relevance 0.11
Serum concentrations of PRL, GH, LH, FSH, TSH and cortisol after single administration to man of a new synthetic narcotic analgesic butorphanol.
Positive_regulation (concentrations) of FSH associated with analgesic and butorphanol
6) Confidence 0.41 Published 1984 Journal Eur. J. Clin. Pharmacol. Section Title Doc Link 6432552 Disease Relevance 0 Pain Relevance 0.81
Naloxone infusion in young male and female normal subjects produced a significant rise in both LH and FSH.
Positive_regulation (rise) of FSH associated with narcan
7) Confidence 0.37 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6784982 Disease Relevance 0.17 Pain Relevance 0.63
Three months after the head injury, the hormonal evaluation of the hypothalamic-pituitary axis by means of insulin stress test with the simultaneous administration of TRH and GnRH resulted in reduced responses of GH, cortisol, TSH, FSH, and LH with low baseline serum concentrations of free T4 and testosterone.
Positive_regulation (responses) of FSH in pituitary associated with stress and brain injury
8) Confidence 0.26 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8796342 Disease Relevance 0.81 Pain Relevance 0.10
In this regard oligozoospermia with elevated FSH levels and decreased frequency of LH pulses has been identified.
Positive_regulation (elevated) of FSH associated with oligospermia
9) Confidence 0.25 Published 1990 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 2081088 Disease Relevance 0.31 Pain Relevance 0.05
In our previous studies, the opioid receptors located on pinealocytes have been identified and characterized, and these receptors have been found to play a stimulatory role in melatonin synthesis by activating the rate limiting enzyme, N-acetyltransferase (NAT).
Positive_regulation (activating) of NAT in pinealocytes associated with opioid receptor
10) Confidence 0.09 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10471401 Disease Relevance 0 Pain Relevance 0.33
Steroid administration to patients with mumps orchitis is not recommended because steroids may further lower the level of testosterone and increase the level of FSH and LH, further aggravating atrophy of the testes31, 32).
Positive_regulation (increase) of FSH associated with mumps and frailty
11) Confidence 0.06 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC2994117 Disease Relevance 2.67 Pain Relevance 0.17
Promotion of NAT activity did not have the same effect on all the compounds tested.
Positive_regulation (Promotion) of NAT
12) Confidence 0.03 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0 Pain Relevance 0
The review concluded that there was no evidence of a difference between both rFSH and HP uFSH for ovulation induction in women with PCOS.
Positive_regulation (induction) of uFSH associated with polycystic ovary syndrome
13) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.40 Pain Relevance 0
The review concluded that there was no evidence of a difference between both rFSH and HP uFSH for ovulation induction in women with PCOS.
Positive_regulation (induction) of rFSH associated with polycystic ovary syndrome
14) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.40 Pain Relevance 0

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