INT53451

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2006
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.07
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TAT) mitochondrion (TAT) small molecule metabolic process (TAT)
biosynthetic process (TAT) cellular nitrogen compound metabolic process (TAT) cellular_component (TAT)
Anatomy Link Frequency
plasma 2
TAT (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 15 100.00 Very High Very High Very High
transdermal 3 100.00 Very High Very High Very High
Angina 12 98.40 Very High Very High Very High
Freund adjuvant 8 84.40 Quite High
Dismenorea 1 79.60 Quite High
abdominal pain 1 78.00 Quite High
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 94 99.52 Very High Very High Very High
Cv General 3 Under Development 11 98.40 Very High Very High Very High
Disseminated Intravascular Coagulation 3 95.36 Very High Very High Very High
Angina 1 94.32 High High
Infection 28 92.04 High High
Myocardial Infarction 5 90.64 High High
Cv Unclassified Under Development 1 87.00 High High
Dysmenorrhea 1 79.60 Quite High
Toxicity 6 79.52 Quite High
Abdominal Pain 1 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, levels of plasma TAT and 11-dehydro-TXB2 in the non-aspirin group remained unchanged during the study period.
Neg (unchanged) Regulation (unchanged) of TAT in plasma associated with aspirin
1) Confidence 0.44 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8480641 Disease Relevance 0.58 Pain Relevance 1.20
The effects of intravenous L-arginine or transdermal nitroglycerin on the plasma level of TAT were also investigated.
Regulation (effects) of TAT in plasma associated with transdermal
2) Confidence 0.44 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10484053 Disease Relevance 0.44 Pain Relevance 0.19
But there were no significant changes in TAT levels in serum.
Neg (no) Regulation (changes) of TAT
3) Confidence 0.26 Published 1994 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 7844439 Disease Relevance 0.39 Pain Relevance 0.08
Of all biochemical markers tested TAT had the highest early sensitivity on admission to the CCU, and TAT was significantly more sensitive than cTnT, CKMB mass, myoglobin, and D-dimer.
Regulation (sensitive) of TAT
4) Confidence 0.26 Published 1997 Journal Clin. Chim. Acta Section Abstract Doc Link 9469256 Disease Relevance 0.63 Pain Relevance 0.09
However, after dalteparin a higher peak value of TAT was observed.
Regulation (value) of TAT
5) Confidence 0.26 Published 2002 Journal J. Am. Coll. Cardiol. Section Body Doc Link 11869846 Disease Relevance 0.05 Pain Relevance 0
These studies outline how mutations can affect Tat cross recognition as shown in former studies [22,27].


Regulation (affect) of Tat
6) Confidence 0.26 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.43 Pain Relevance 0.04
Tat variability follows this geographical diversity with mutations of up to 38 % observed among Tat variants from A, B, C, D and E HIV-1 subtypes that do not alter Tat functions but do not allow cross recognition with Tat antibodies [22].
Neg (not) Regulation (alter) of Tat associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.26 Published 2006 Journal Retrovirology Section Body Doc Link PMC1434768 Disease Relevance 0.54 Pain Relevance 0

General Comments

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