INT53468

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Context Info
Confidence 0.24
First Reported 1994
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 20.87
Pain Relevance 2.95

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mitochondrion (Acsm3) molecular_function (Acsm3) cellular_component (Acsm3)
ligase activity (Acsm3) biological_process (Acsm3) lipid metabolic process (Acsm3)
Anatomy Link Frequency
platelet 1
lung 1
Acsm3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 141 100.00 Very High Very High Very High
aspirin 10 100.00 Very High Very High Very High
depression 168 99.56 Very High Very High Very High
drug abuse 168 99.06 Very High Very High Very High
alcohol 624 94.64 High High
addiction 120 94.00 High High
Analgesic 1 90.96 High High
Inflammatory mediators 16 85.36 High High
Inflammation 39 75.00 Quite High
opiate 24 67.76 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 864 100.00 Very High Very High Very High
Subarachnoid Hemorrhage 133 100.00 Very High Very High Very High
Personality Disorder 96 99.98 Very High Very High Very High
Paranoid Personality Disorder 192 99.92 Very High Very High Very High
Adult Respiratory Distress Syndrome 10 99.84 Very High Very High Very High
Anxiety Disorder 168 99.80 Very High Very High Very High
Depressive Disorder 24 99.68 Very High Very High Very High
Depression 192 99.56 Very High Very High Very High
Generalized Anxiety Disorder 288 99.38 Very High Very High Very High
Panic Disorder 48 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the major systemic complications associated with SAH is acute lung injury (ALI) which occurs in up to one-third of the patients and is associated with poor outcome.
SAH Binding (associated) of in lung associated with adult respiratory distress syndrome and cva
1) Confidence 0.24 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2945141 Disease Relevance 1.36 Pain Relevance 0.45
This prompted us to study the interaction of salicylamide with aspirin and/or SA on rat platelet and cyclooxygenase.
SA Binding (interaction) of in platelet associated with aspirin
2) Confidence 0.17 Published 1994 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 7846108 Disease Relevance 0 Pain Relevance 0.43
B binding activity in the basilar arteries post SAH, EMSA was performed to detect the changes of NF-?
SAH Binding (binding) of associated with cva
3) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821769 Disease Relevance 1.36 Pain Relevance 0.62
In addition, a study of comorbidity patterns in German adolescents and young adults who had attempted suicide showed that the comorbidity of the number of diagnoses, and especially comorbidity with multiple diagnoses (anxiety plus depressive disorders), was strongly associated with SA [27].
SA Binding (associated) of associated with suicidal behaviour, anxiety disorder and depressive disorder
4) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.51 Pain Relevance 0.07
These analyses differ from the longitudinal design of this study, because the association between SA and use of substances in the last year is cross-sectional.
SA Binding (association) of
5) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.46 Pain Relevance 0.17
In the multivariate analyses, the number of Axis I disorders, number of Axis II disorders, and the sum of all these disorders were not independently associated with SA in the observation period.
SA Binding (associated) of
6) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.33 Pain Relevance 0
Comorbidity of Axis I and II (patients who simultaneously satisfied the criteria of one or more Axis I and Axis II disorders, n = 100) was not significantly associated with SA in the observation period (23% vs 14%, p = 0.204).
SA Binding (associated) of
7) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.78 Pain Relevance 0
There was a weak association between lifetime SA measured at index admission and new SA in the six-year observation period (24% vs 13%, p = 0.086).
SA Binding (association) of
8) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 1.54 Pain Relevance 0
When using MCMI-II dimensionally, only paranoid PD was significantly associated with SA.
SA Binding (associated) of associated with paranoid personality disorder
9) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.91 Pain Relevance 0
Anxiety disorders are also associated with SA in SUD patients [6,7,23,25,26], although there are contradicting results regarding the association between SA and anxiety disorders in general population-based studies [27-29].
SA Binding (association) of associated with drug dependence and anxiety disorder
10) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 1.25 Pain Relevance 0.12
In the multivariate analyses, there was only a tendency towards an association between low education and SA.
SA Binding (association) of
11) Confidence 0.05 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.38 Pain Relevance 0.10
There was no interaction between GAD and the personality disorders associated with SA.
SA Binding (associated) of associated with generalized anxiety disorder and personality disorder
12) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.78 Pain Relevance 0.03
There was a weak association between lifetime SA measured at index admission and new SA in the six-year observation period (24% vs 13%, p = 0.086).
SA Binding (association) of
13) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 1.54 Pain Relevance 0
Other prospective studies have found little association between SA and baseline Axis I disorders [17,34], and Axis II disorders [12].
SA Neg (little) Binding (association) of
14) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.88 Pain Relevance 0.10
None of the specific Axis II disorders or number of Axis II disorders was independently associated with SA in the observation period.
SA Binding (associated) of
15) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.88 Pain Relevance 0.04
Further, there were no associations between SUD variables measured at baseline, or at follow-up, and SA.
SA Neg (no) Binding (associations) of associated with drug dependence
16) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.47 Pain Relevance 0.03
Four of the thirteen Axis II disorders were significantly associated with SA: paranoid personality disorder (PD); schizotypal PD; borderline PD; and passive-aggressive PD.
SA Binding (associated) of associated with paranoid personality disorder
17) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 1.07 Pain Relevance 0
In a series of multivariate analyses, the HSCL-25 score at T1, number of Axis I disorders, and the total number of Axis I and II disorders were not independently associated with SA in the observation period.
SA Binding (associated) of
18) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.79 Pain Relevance 0.04
At the index admission, lifetime eating disorders, agoraphobia with and without panic disorder, and major depression were significantly and independently associated with SA.
SA Binding (associated) of associated with panic disorder, appetite loss, depression and agoraphobia
19) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Abstract Doc Link PMC2098764 Disease Relevance 0.83 Pain Relevance 0.17
Finally, multiple logistic regression analyses (method: enter, block-wise) were used to assess the controlled effects of predictors showing significant bivariate associations with SA in the observation period and controlling for harmful use of substances at follow-up or in the preceding year.
SA Binding (associations) of
20) Confidence 0.04 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2098764 Disease Relevance 0.38 Pain Relevance 0

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