INT53482

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Context Info
Confidence 0.77
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 75
Total Number 83
Disease Relevance 58.87
Pain Relevance 26.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
urine 7
neurons 7
brain 4
macrophages 2
Spinal 2
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1187 100.00 Very High Very High Very High
dorsal root ganglion 780 100.00 Very High Very High Very High
Morphine 98 100.00 Very High Very High Very High
Opioid receptor 1 1 100.00 Very High Very High Very High
intrathecal 24 99.98 Very High Very High Very High
Pain 331 99.96 Very High Very High Very High
cytokine 165 99.96 Very High Very High Very High
allodynia 31 99.96 Very High Very High Very High
Dorsal horn 99 99.68 Very High Very High Very High
drug abuse 19 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 3358 100.00 Very High Very High Very High
Ganglion Cysts 780 100.00 Very High Very High Very High
Gliosis 72 100.00 Very High Very High Very High
Targeted Disruption 5 100.00 Very High Very High Very High
Neuropathic Pain 618 99.96 Very High Very High Very High
Pain 266 99.96 Very High Very High Very High
Drug Dependence 18 99.66 Very High Very High Very High
Severe Combined Immunodeficiency 6 99.60 Very High Very High Very High
Cancer 226 99.12 Very High Very High Very High
Apoptosis 255 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1beta, although up-regulating the expression of alpha(1)-acid glycoprotein in these cells, did not induce any effect in the expression of ITIH4.
Gene_expression (expression) of ITIH4
1) Confidence 0.77 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10486281 Disease Relevance 0.15 Pain Relevance 0.12
The precise reason for the reduced levels of the ITIH4 fragment in the urine of patients with ovarian carcinoma that is observed in this study is currently not understood.
Gene_expression (levels) of ITIH4 in urine associated with ovarian cancer
2) Confidence 0.75 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 1.19 Pain Relevance 0.19
Further confirmation of the altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma relative to those of the control subjects was performed using antibodies and a lectin that bind to the respective proteins that were blotted onto membranes.
Gene_expression (levels) of ITIH4 in urine associated with ovarian cancer
3) Confidence 0.75 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.47 Pain Relevance 0
Using the hepatocarcinoma HepG2 cell line we have observed up-regulation of ITIH4 mRNA expression upon dose-response treatments with interleukin-6 (IL-6).
Gene_expression (expression) of ITIH4
4) Confidence 0.67 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10486281 Disease Relevance 0.18 Pain Relevance 0.13
Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
Gene_expression (administration) of gp120 associated with allodynia, thermal hyperalgesia, acquired immune deficiency syndrome or hiv infection and intrathecal
5) Confidence 0.67 Published 2000 Journal Brain Res. Section Title Doc Link 10751570 Disease Relevance 1.45 Pain Relevance 1.22
The immune stimulus used was peri-spinal (intrathecal, i.t.) application of the Human Immunodeficiency Virus type 1 (HIV-1) envelope glycoprotein, gp120.
Gene_expression (application) of gp120 in spinal associated with acquired immune deficiency syndrome or hiv infection and intrathecal
6) Confidence 0.67 Published 2000 Journal Brain Res. Section Abstract Doc Link 10751570 Disease Relevance 1.63 Pain Relevance 1.42
The largest aberration in gene expression, however, was observed during inflammation of the neonatally injured hindpaws in the ipsilateral LDH, which included thirty-six genes (encoding numerous members of glutamate, serotonin, GABA, calcitonin gene-related peptide, neurotrophin, and interleukin systems).
Gene_expression (systems) of inter in LDH associated with gaba, glutamate, inflammation, spinal dorsal horn, serotonin and calcitonin gene-related peptide
7) Confidence 0.65 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1242251 Disease Relevance 0.26 Pain Relevance 0.95
, IL-5, IL-6, IL-12A, IL-15, IL-20, IL-24) and the interleukin receptor, IL-12 ?
Gene_expression (receptor) of inter
8) Confidence 0.65 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.59 Pain Relevance 0.49
We have previously shown that, in CHP100 cells, picomolar concentrations of gp120 produce a significant increase in cell death, which seems to proceed through a Ca(2+) - and NMDA receptor-dependent cascade.
Gene_expression (produce) of gp120 associated with nmda receptor and death
9) Confidence 0.64 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820198 Disease Relevance 1.34 Pain Relevance 0.32
Intrathecal gp120 produced time-dependent, site-specific increases in TNF and IL-1 protein release into lumbosacral CSF; parallel cytokine increases in lumbar dorsal spinal cord were also observed.
Gene_expression (produced) of gp120 in dorsal associated with spinal cord, cytokine and intrathecal
10) Confidence 0.64 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11306633 Disease Relevance 1.20 Pain Relevance 1.36
Significant reduced levels of CD59, kininogen-1 and a 39 kDa fragment of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), and enhanced excretion of a 19 kDa fragment of albumin, were detected in the urine of patients with ovarian carcinoma compared to the control subjects.
Gene_expression (levels) of inhibitor heavy chain H4 in urine associated with ovarian cancer
11) Confidence 0.59 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC2998473 Disease Relevance 0.52 Pain Relevance 0
Significant reduced levels of CD59, kininogen-1 and a 39 kDa fragment of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), and enhanced excretion of a 19 kDa fragment of albumin, were detected in the urine of patients with ovarian carcinoma compared to the control subjects.
Gene_expression (levels) of ITIH4 in urine associated with ovarian cancer
12) Confidence 0.59 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC2998473 Disease Relevance 0.52 Pain Relevance 0
When taken as overall, the levels of CD59, kininogen-1 and ITIH4 fragment were significantly lower in ovarian carcinoma patients by 3.6-, 2.5- and 1.9-folds, respectively, compared to those excreted by the control subjects.
Gene_expression (levels) of ITIH4 associated with ovarian cancer
13) Confidence 0.59 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.43 Pain Relevance 0
This inverse relationship and the difference in the molecular masses of the ITIH4 fragments detected in the respective samples suggest presence of a selective glomerular filtration mechanism that retained the 35 kDa fragment in the blood but allowed its 39 kDa counterpart to be excreted in the urine.
Gene_expression (detected) of ITIH4 in urine
14) Confidence 0.59 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.69 Pain Relevance 0.11
The different altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma, relative to the controls, was confirmed when their 2-DE urine protein profiles were subjected to image analysis using the Image Master 2 D Platinum Software 7.0.
Gene_expression (levels) of ITIH4 in urine associated with ovarian cancer
15) Confidence 0.59 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.23 Pain Relevance 0
HIV gp120 and morphine alter mu opiate receptor expression in human vascular endothelium.
Gene_expression (expression) of gp120 in vascular endothelium associated with acquired immune deficiency syndrome or hiv infection, opioid receptor 1 and morphine
16) Confidence 0.58 Published 2001 Journal Int. J. Mol. Med. Section Title Doc Link 11445868 Disease Relevance 0.19 Pain Relevance 0.74
METHODS: Tubular cell-morphine and/or gp120 interaction products were prepared by incubating confluent human proximal tubular cells with buffer (TCP), morphine (10(-3) mol/L) (TCM-IP), gp120 (0.01 microgram/mL)(TC-120IP), or morphine (10(-3) mol/L) + gpl20 (0.01 microgram/mL) (TCM-120IP).
Gene_expression (prepared) of gp120 in proximal
17) Confidence 0.52 Published 1998 Journal J. Investig. Med. Section Body Doc Link 9676058 Disease Relevance 0.19 Pain Relevance 0
The proteomic profiling of urine samples demonstrated reduced levels of CD59, kininogen-1 and a 39 kDa ITIH4 fragment, as well as the enhanced excretion of a 19 kDa fragment of albumin in patients with ovarian carcinoma compared to control women.
Gene_expression (levels) of ITIH4 in urine associated with ovarian cancer
18) Confidence 0.51 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.52 Pain Relevance 0
This suggested that the ITIH4 and albumin spots detected in the 2-DE urinary profiles were truncated fragments of their native molecules.
Gene_expression (detected) of ITIH4
19) Confidence 0.51 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.12 Pain Relevance 0
Administration of gp120 alone results in significant increases in reactive oxygen species, whereas coadministration with cortisol increases the amount of lipid
Gene_expression (Administration) of gp120
20) Confidence 0.47 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.17 Pain Relevance 0.03

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