INT53495

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.37
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKCA) mitochondrion (PRKCA) small molecule metabolic process (PRKCA)
endoplasmic reticulum (PRKCA) enzyme binding (PRKCA) cytoplasm (PRKCA)
Anatomy Link Frequency
myocardium 2
lung 2
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 63 100.00 Very High Very High Very High
Morphine 3 100.00 Very High Very High Very High
Nicotine 17 99.98 Very High Very High Very High
5HT 141 99.56 Very High Very High Very High
methadone 2 98.08 Very High Very High Very High
antidepressant 19 97.60 Very High Very High Very High
Opioid 9 96.64 Very High Very High Very High
opioid receptor 1 90.96 High High
Kinase C inhibitor 1 85.32 High High
antagonist 11 80.68 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 12 99.50 Very High Very High Very High
Lung Cancer 8 99.08 Very High Very High Very High
Anxiety Disorder 89 98.28 Very High Very High Very High
Cancer 6 98.04 Very High Very High Very High
Pain 2 64.64 Quite High
Nicotine Addiction 2 47.60 Quite Low
Death 1 41.60 Quite Low
Cv Unclassified Under Development 13 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that nicotine, like phorbol 12-myristate 13-acetate, increased total protein kinase C (PKC) activity, while morphine and sphingosine decreased PKC activity, and nicotine reversed morphine inhibition of PKC activity.
Negative_regulation (reversed) of Negative_regulation (inhibition) of PKC associated with kinase c, nicotine and morphine
1) Confidence 0.42 Published 1994 Journal Cell Growth Differ. Section Abstract Doc Link 7848904 Disease Relevance 0.95 Pain Relevance 1.76
But again, the mechanism of preconditioning the human myocardium may not be applicable to all species as suggested by the need to combine the inhibition of PKC and tyrosine kinase to abort the protection of preconditioning in pigs. [30]
Negative_regulation (combine) of Negative_regulation (inhibition) of PKC in myocardium associated with kinase c
2) Confidence 0.36 Published 2002 Journal BMC Physiol Section Body Doc Link PMC117790 Disease Relevance 0.12 Pain Relevance 0.46
The present study provides evidence that nicotine (a) activates the mitogen-activated protein (MAP) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (ERK2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase C (PKC) and ERK2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy.
Negative_regulation (blocks) of Negative_regulation (inhibition) of PKC in lung associated with kinase c, lung cancer, cancer, nicotine, apoptosis and opioid
3) Confidence 0.32 Published 1998 Journal Carcinogenesis Section Abstract Doc Link 9600337 Disease Relevance 0.95 Pain Relevance 0.52
An enhanced 5HT reuptake rate with a decrease in the inhibitory effect of PKC occurred after six months of treatment of OCD with various SRIs (Marazziti et al 2002).
Negative_regulation (decrease) of Negative_regulation (decrease) of PKC associated with antidepressant, kinase c, anxiety disorder and 5ht
4) Confidence 0.16 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.35 Pain Relevance 0.44

General Comments

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