INT53516

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 6.86
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA1A) cell death (CACNA1A) plasma membrane (CACNA1A)
nucleus (CACNA1A) transmembrane transport (CACNA1A) cytoplasm (CACNA1A)
Anatomy Link Frequency
brain 1
CACNA1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 113 100.00 Very High Very High Very High
Gabapentin 3 94.68 High High
Inflammation 4 85.92 High High
Calcium channel 19 75.00 Quite High
Neurotransmitter 6 65.84 Quite High
ergotamine 1 64.16 Quite High
Triptan 1 63.56 Quite High
Opioid 1 54.48 Quite High
headache 31 14.12 Low Low
depression 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine With Aura 29 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 20 100.00 Very High Very High Very High
Disease 10 99.96 Very High Very High Very High
Epilepsy 10 99.76 Very High Very High Very High
Migraine Disorders 83 99.04 Very High Very High Very High
Ataxia 29 97.48 Very High Very High Very High
Increased Venous Pressure Under Development 4 96.16 Very High Very High Very High
Headache 34 92.80 High High
INFLAMMATION 4 85.92 High High
Brain Hemorrhage 4 82.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results indicate that both alpha2delta-2 and CaV2.1 are normally associated with cholesterol-rich microdomains, and this influences their functionality.
CaV2.1 Binding (associated) of
1) Confidence 0.47 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16928863 Disease Relevance 0 Pain Relevance 0.32
In conclusion, the clinical and molecular findings reported here suggest the opportunity to screen for point mutation in this gene, even patients with a clinical phenotype for some aspects slightly different from the typical picture more commonly associated to SCA6, EA2 or FHM1 diseases.
SCA6 Binding (associated) of associated with spinocerebellar ataxia type 2 and disease
2) Confidence 0.37 Published 2006 Journal J. Neurol. Sci. Section Abstract Doc Link 16325861 Disease Relevance 0.61 Pain Relevance 0
SCA6 is associated with small expansions of a CAG repeat at the 3' end of the gene, while point mutations are mostly responsible for its two allelic disorders, FHMI and EA2.
SCA6 Binding (associated) of associated with spinocerebellar ataxia type 2
3) Confidence 0.37 Published 2006 Journal J. Neurol. Sci. Section Abstract Doc Link 16325861 Disease Relevance 0.64 Pain Relevance 0.17
In conclusion, the clinical and molecular findings reported here suggest the opportunity to screen for point mutation in this gene, even patients with a clinical phenotype for some aspects slightly different from the typical picture more commonly associated to SCA6, EA2 or FHM1 diseases.
EA2 Binding (associated) of associated with spinocerebellar ataxia type 2 and disease
4) Confidence 0.37 Published 2006 Journal J. Neurol. Sci. Section Abstract Doc Link 16325861 Disease Relevance 0.61 Pain Relevance 0
In conclusion, the clinical and molecular findings reported here suggest the opportunity to screen for point mutation in this gene, even patients with a clinical phenotype for some aspects slightly different from the typical picture more commonly associated to SCA6, EA2 or FHM1 diseases.
FHM1 Binding (associated) of associated with spinocerebellar ataxia type 2 and disease
5) Confidence 0.37 Published 2006 Journal J. Neurol. Sci. Section Abstract Doc Link 16325861 Disease Relevance 0.61 Pain Relevance 0
Mutations in all three FHM genes can also be associated with epilepsy.
FHM Binding (associated) of associated with epilepsy and migraine
6) Confidence 0.36 Published 2008 Journal Expert Rev Neurother Section Abstract Doc Link 18759542 Disease Relevance 1.20 Pain Relevance 0.82
Recent assignment of FHM locus to chromosome 19p in two French families makes it now possible to test this hypothesis.
FHM Binding (assignment) of associated with migraine
7) Confidence 0.36 Published 1994 Journal Genomics Section Abstract Doc Link 7851903 Disease Relevance 0.93 Pain Relevance 0.89
Migraine with aura is not linked to the FHM gene CACNA1A or the chromosomal region, 19p13.
FHM Binding (linked) of associated with migraine
8) Confidence 0.36 Published 2002 Journal Neurology Section Title Doc Link 12370474 Disease Relevance 0.63 Pain Relevance 0.29
We next wished to ask whether the CACNA1A RE1 sites recruit REST in vivo, and whether the degree of that recruitment reflects their in vitro binding affinity.
CACNA1A Spec (whether) Binding (recruit) of
9) Confidence 0.31 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.05 Pain Relevance 0
Furthermore, identification of a migraine-specific gene at chromosome 19p13, known to be associated with missense mutations in the brain-specific P/Q-type Ca2+ channel alpha1-subunit gene, CACNA1A [45], raises the possibility that genetic regulators of calcium homeostasis may contribute to determining migraine susceptibility.
CACNA1A Binding (associated) of in brain associated with migraine
10) Confidence 0.30 Published 2010 Journal BMC Womens Health Section Body Doc Link PMC2984417 Disease Relevance 1.59 Pain Relevance 0.87

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