INT53525

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Context Info
Confidence 0.35
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.81
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NXT1) intracellular (NXT1) cytoplasm (NXT1)
Anatomy Link Frequency
plasma 1
NXT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 8 99.12 Very High Very High Very High
Opioid 11 99.08 Very High Very High Very High
Pain 20 95.88 Very High Very High Very High
Osteoarthritis 171 92.64 High High
Inflammatory response 1 92.00 High High
antagonist 4 78.68 Quite High
opiate 1 78.24 Quite High
addiction 3 69.84 Quite High
Endogenous opioid 2 66.76 Quite High
narcan 1 64.20 Quite High
Disease Link Frequency Relevance Heat
Hypercalcemia 30 99.20 Very High Very High Very High
Bone Cancer 10 98.24 Very High Very High Very High
Low Back Pain 8 97.08 Very High Very High Very High
Pain 15 95.88 Very High Very High Very High
Aging 2 95.64 Very High Very High Very High
Osteoarthritis 27 92.64 High High
INFLAMMATION 1 92.00 High High
Malignant Neoplastic Disease 4 89.64 High High
Cancer 4 88.68 High High
Obesity 42 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The plasma NTX levels in rats showed that for compressed microspheres NTX concentrations were constant and exceeded 2 ng/mL for 28 days.
Positive_regulation (constant) of NTX in plasma
1) Confidence 0.35 Published 2006 Journal Drug Dev Ind Pharm Section Abstract Doc Link 16455607 Disease Relevance 0.09 Pain Relevance 0.15
A 100-fold excess of NTX or a variety of other opioid ligands did not alter the temporal-spatial distribution of FNTX.
Positive_regulation (excess) of NTX associated with opioid
2) Confidence 0.09 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19605761 Disease Relevance 0.16 Pain Relevance 0.25
This indicates that when the pH of polymeric solution is lower or higher than 7.4, diffusion of NTX is increased.
Positive_regulation (increased) of NTX
3) Confidence 0.08 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2948935 Disease Relevance 0 Pain Relevance 0
Ln-NTx (Ln is the natural log) exhibited a significant association with BMLs, with the odds of a BML being present increasing by 1.4-fold (95% confidence interval = 1.0-fold to 2.0-fold) per 1 standard deviation increase in the LnNTx, and with a small partial R2 of 3.05.
Positive_regulation (increase) of LnNTx
4) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575616 Disease Relevance 0.32 Pain Relevance 0.05
Elevated levels of urinary NTx indicate elevated human bone resorption [40], and our data suggest that their levels are increased in persons with BMLs.
Positive_regulation (levels) of NTx associated with hypercalcemia
5) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.68 Pain Relevance 0.19
Ln-NTx exhibited a significant association with BMLs, with the odds of a BML being present increasing by 1.4-fold (95% confidence interval = 1.0-fold to 2.0-fold) per 1 standard deviation increase in the LnNTx, and with a small partial R2 of 3.05.
Positive_regulation (increase) of LnNTx
6) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.23 Pain Relevance 0.06
We also showed that NTX and BAP levels increased significantly in women over 80 years, and specifically in patients with back pain.
Positive_regulation (increased) of NTX associated with backache
7) Confidence 0.04 Published 2005 Journal J. Bone Miner. Metab. Section Abstract Doc Link 16261458 Disease Relevance 0.64 Pain Relevance 0.50
Both BAP and NTX levels increased in individuals over 60 years of age; moreover, these markers were significantly higher in subjects aged over 80 years.
Positive_regulation (increased) of NTX
8) Confidence 0.04 Published 2005 Journal J. Bone Miner. Metab. Section Abstract Doc Link 16261458 Disease Relevance 0.59 Pain Relevance 0.45
At baseline, 80-95% of patients showed elevated urinary pyridinoline, deoxypyridinoline, Osteomark NTx and serum ICTP levels, whereas only 35% of patients had elevated urinary CrossLaps excretion rates.
Positive_regulation (elevated) of Osteomark NTx
9) Confidence 0.01 Published 1998 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 9877095 Disease Relevance 1.16 Pain Relevance 0.29
Several studies have shown that NTX, CTX, and ICTP are elevated in myeloma patients, reflect the extent of bone disease, and correlate with survival.
Positive_regulation (elevated) of NTX associated with bone cancer
10) Confidence 0.01 Published 2006 Journal Cancer Treat. Rev. Section Abstract Doc Link 16680833 Disease Relevance 0.89 Pain Relevance 0.08
Estradiol levels also increased on the first NTX day (P < 0.01).
Positive_regulation (increased) of NTX
11) Confidence 0.00 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7852517 Disease Relevance 0.05 Pain Relevance 0.39

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