INT53532

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 11.57
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcp1) plasma membrane (Lcp1) cytoskeleton (Lcp1)
cytoplasm (Lcp1)
Anatomy Link Frequency
leukocytes 4
T-cell 1
Lcp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 98.16 Very High Very High Very High
peripheral neuropathy 18 97.84 Very High Very High Very High
local anesthetic 5 96.24 Very High Very High Very High
Inflammation 185 92.24 High High
Inflammatory response 56 83.80 Quite High
cytokine 50 78.32 Quite High
methotrexate 5 52.92 Quite High
cINOD 4 52.36 Quite High
alcohol 1 20.20 Low Low
rheumatoid arthritis 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 296 100.00 Very High Very High Very High
Injury 323 99.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 13 99.24 Very High Very High Very High
Disease 38 99.16 Very High Very High Very High
Peripheral Neuropathy 18 97.84 Very High Very High Very High
Infection 159 97.76 Very High Very High Very High
INFLAMMATION 244 92.24 High High
Retinitis 6 81.76 Quite High
Cancer 8 79.04 Quite High
Malignant Neoplastic Disease 3 78.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The wound-restricted expression pattern of L-plastin suggests that expression of this gene is limited to activated leukocytes only.
Gene_expression (expression) of L-plastin in leukocytes associated with injury
1) Confidence 0.70 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.12 Pain Relevance 0.15
CMV-reactive PBLs were stimulated with specific pp65 CMV peptide (amino acid sequence: TPRVTGGGAM, from Proimmune, Oxford, United Kingdom) in the presence of 50 U/mL IL-2 and 10 ng/mL IL-7 for up to 8 days prior to staining with anti-TCR?
Gene_expression (peptide) of pp65 associated with cytomegalovirus infection
2) Confidence 0.65 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.20 Pain Relevance 0.14
The wound-restricted expression pattern of L-plastin suggests that expression of this gene is limited to activated leukocytes only.
Gene_expression (expression) of L-plastin in leukocytes associated with injury
3) Confidence 0.54 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 1.12 Pain Relevance 0.15
The immune responses of mice injected with plasmids VR-gB and VR-gB Delta tm expressing the full-length membrane-anchored, or secreted forms of human cytomegalovirus (HCMV)-glycoprotein B (gB), respectively, and VR-pp65 expressing the HCMV-phosphoprotein 65 (pp65) were analyzed.
Gene_expression (expressing) of pp65 associated with cytomegalovirus infection
4) Confidence 0.37 Published 2001 Journal Vaccine Section Abstract Doc Link 11427273 Disease Relevance 0.45 Pain Relevance 0.09
The immune responses of mice injected with plasmids VR-gB and VR-gB Delta tm expressing the full-length membrane-anchored, or secreted forms of human cytomegalovirus (HCMV)-glycoprotein B (gB), respectively, and VR-pp65 expressing the HCMV-phosphoprotein 65 (pp65) were analyzed.
Gene_expression (expressing) of pp65 associated with cytomegalovirus infection
5) Confidence 0.32 Published 2001 Journal Vaccine Section Abstract Doc Link 11427273 Disease Relevance 0.45 Pain Relevance 0.09
The immune responses of mice injected with plasmids VR-gB and VR-gB Delta tm expressing the full-length membrane-anchored, or secreted forms of human cytomegalovirus (HCMV)-glycoprotein B (gB), respectively, and VR-pp65 expressing the HCMV-phosphoprotein 65 (pp65) were analyzed.
Gene_expression (expressing) of pp65 associated with cytomegalovirus infection
6) Confidence 0.29 Published 2001 Journal Vaccine Section Abstract Doc Link 11427273 Disease Relevance 0.45 Pain Relevance 0.10
RT-PCR examining expression of pp65, IE1, IE2, and pol mRNA in infected cells
Gene_expression (expression) of pp65
7) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.02 Pain Relevance 0
dominant CD4+CD28null T-cell subsets did not respond either to pp65 or to immediate early antigens, indicating that the TCR-V?
Neg (not) Gene_expression (respond) of pp65 in T-cell
8) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212553 Disease Relevance 0.58 Pain Relevance 0.08
Detection of cytomegalovirus-matrix protein (pp65) in leukocytes of HIV-infected patients with painful peripheral neuropathy.
Gene_expression (Detection) of pp65 in leukocytes associated with pain, acquired immune deficiency syndrome or hiv infection, cytomegalovirus infection and peripheral neuropathy
9) Confidence 0.06 Published 1994 Journal J. Med. Virol. Section Title Doc Link 7852958 Disease Relevance 2.84 Pain Relevance 0.48
The detection of CMV-matrix pp65 antigen in the blood and CSF leukocytes could represent a simple and rapid tool of selecting PPN patients for antiviral therapy.
Gene_expression (detection) of pp65 in leukocytes associated with cytomegalovirus infection and peripheral neuropathy
10) Confidence 0.05 Published 1994 Journal J. Med. Virol. Section Abstract Doc Link 7852958 Disease Relevance 3.34 Pain Relevance 0.41

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