INT53546

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.24
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
liver 2
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 16 100.00 Very High Very High Very High
Paracetamol 1 100.00 Very High Very High Very High
antagonist 5 99.38 Very High Very High Very High
alcohol 3 88.68 High High
Gabapentin 3 72.44 Quite High
anticonvulsant 2 72.08 Quite High
carbamazepine 13 71.56 Quite High
lidocaine 1 68.24 Quite High
Opioid 1 59.88 Quite High
Lamotrigine 5 53.68 Quite High
Disease Link Frequency Relevance Heat
Schizophrenia 28 99.04 Very High Very High Very High
Toxicity 2 89.04 High High
Convulsion 35 50.52 Quite High
Epilepsy 24 50.00 Quite Low
Mental Disorders 4 18.84 Low Low
Body Weight 2 13.28 Low Low
Partial Seizures 14 5.00 Very Low Very Low Very Low
Cognitive Disorder 13 5.00 Very Low Very Low Very Low
Recurrence 12 5.00 Very Low Very Low Very Low
Dizziness 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For CYP2B6, the interaction between enantiomers was stereoselective, with S-methadone as a more potent inhibitor of R-methadone N-demethylation than R-of S-methadone.
Negative_regulation (inhibitor) of CYP2B6 Binding (interaction) of associated with methadone
1) Confidence 0.43 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17259447 Disease Relevance 0 Pain Relevance 1.09
However, the covalent binding of the acetaminophen intermediate, formed via P450 2E1, was unaffected by addition of the flavonoids.
Neg (unaffected) Negative_regulation (unaffected) of P450 Binding (binding) of associated with paracetamol
2) Confidence 0.42 Published 1994 Journal Chem. Biol. Interact. Section Abstract Doc Link 8194125 Disease Relevance 0.09 Pain Relevance 0.18
These results indicate that histamine H1 receptor antagonists such as mepyramine are potent inhibitors of P450 2D forms because of their high affinity for these enzymes.
Negative_regulation (inhibitors) of P450 Binding (affinity) of associated with antagonist
3) Confidence 0.34 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853212 Disease Relevance 0 Pain Relevance 0.23
The activity of CYP1A2, CYP2A6, CYP2B6, CYP2D6, CYP2E1, CYP3A4, and CYP2C9 was not affected, and only a moderate inhibitory effect on CYP2C19 (by 38%), as well as a moderate increment of UDP-glucuronosyl-transferase 1A1-mediated ethinylestradiol glucuronidation (by 39%), was seen in the presence of ESL in human liver microsomes in vitro.36

In vivo studies

Neg (not) Negative_regulation (affected) of CYP2B6 Binding (activity) of in liver
4) Confidence 0.18 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987506 Disease Relevance 0.05 Pain Relevance 0.17
Does avoidance of the P-450 system reduce the potential for unwanted drug-drug interactions in real world settings?
Negative_regulation (reduce) of P-450 Binding (interactions) of
5) Confidence 0.13 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770423 Disease Relevance 0.10 Pain Relevance 0

General Comments

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