INT5356

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 3
Speculated 8
Reported most in Abstract
Documents 153
Total Number 164
Disease Relevance 54.21
Pain Relevance 56.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
neurons 10
spinal cord 8
neuronal 7
thalamus 4
immune cells 3
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 311 100.00 Very High Very High Very High
Pain 142 100.00 Very High Very High Very High
Spinal cord 86 100.00 Very High Very High Very High
Neuropeptide 76 100.00 Very High Very High Very High
Nerve growth factor 15 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 4 100.00 Very High Very High Very High
Opioid 73 99.98 Very High Very High Very High
alcohol 59 99.98 Very High Very High Very High
qutenza 48 99.98 Very High Very High Very High
fortral 30 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 7 100.00 Very High Very High Very High
Stress 662 99.98 Very High Very High Very High
Nociception 137 99.98 Very High Very High Very High
Dyskinesias 8 99.98 Very High Very High Very High
Repression 8 99.84 Very High Very High Very High
Hyperalgesia 16 99.76 Very High Very High Very High
Pain 141 99.74 Very High Very High Very High
Hypoxia 35 99.56 Very High Very High Very High
Cancer 371 99.52 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

83 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of all tooth pulps induced ipsilateral Fos in the trigeminal subnuclei caudalis and oralis.
Positive_regulation (induced) of Fos in tooth pulps
1) Confidence 0.69 Published 2007 Journal Eur. J. Oral Sci. Section Abstract Doc Link 17305715 Disease Relevance 0.31 Pain Relevance 0.27
Fos was induced in the nucleus tractus solitarii (NTS) of hypotensive piglets.
Positive_regulation (induced) of Fos in nucleus associated with hypotension
2) Confidence 0.69 Published 1996 Journal Brain Res. Section Abstract Doc Link 8822357 Disease Relevance 0.24 Pain Relevance 0.15
Fos was also induced in a dorsal intermediate reticular zone of LTF.
Positive_regulation (induced) of Fos in dorsal
3) Confidence 0.69 Published 1996 Journal Brain Res. Section Abstract Doc Link 8822357 Disease Relevance 0.23 Pain Relevance 0.23
Induction of Fos protein, reflecting neuronal activation, was investigated in the spinal cord with immunohistochemistry.
Spec (investigated) Positive_regulation (Induction) of Fos in spinal cord associated with spinal cord
4) Confidence 0.68 Published 2004 Journal Brain Res. Bull. Section Abstract Doc Link 14709347 Disease Relevance 0.60 Pain Relevance 1.01
Studies suggest that acupuncture and related techniques trigger a sequence of events that include the release of neurotransmitters, endogenous opioid-like substances, and activation of c-fos within the central nervous system.
Spec (like) Positive_regulation (activation) of c-fos in central nervous system associated with neurotransmitter, endogenous opioid, central nervous system and acupuncture
5) Confidence 0.67 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18227322 Disease Relevance 0.09 Pain Relevance 0.91
In all brain regions analysed, exposure to CRD induced an increase in c-Fos activation in both the WKY and SD rats.
Positive_regulation (activation) of c-Fos in brain
6) Confidence 0.67 Published 2010 Journal Neuroscience Section Abstract Doc Link 19765638 Disease Relevance 0.76 Pain Relevance 0.76
In addition, PKC and AP1 subunits c-Jun and c-Fos were also upregulated.
Positive_regulation (upregulated) of c-Fos
7) Confidence 0.67 Published 2001 Journal Anticancer Res. Section Body Doc Link 11501838 Disease Relevance 0.07 Pain Relevance 0
Ensure cues increased c-fos in all of the analyzed thalamic and hypothalamic regions (Figure 5E,F).


Positive_regulation (increased) of c-fos
8) Confidence 0.67 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0 Pain Relevance 0.18
Finally, blockade of ERK 1/2 phosphorylation with the mitogen-activated protein kinase (MEK) 1/2 inhibitor SL327 blocked alcohol-induced c-Fos expression, suggesting that alcohol induces c-Fos in Edinger-Westphal neurons through activation of the MEK1/2-ERK1/2-Stat3 pathway.
Positive_regulation (induces) of c-Fos in neurons associated with alcohol
9) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0 Pain Relevance 0.54
This “upward” shift in sensitized animals, visible in the histogram of optical density frequencies, indicates that the increase in c-fos positive nuclei is not due to nuclei that were under our detection threshold for c-fos increasing their reactivity enough to be measured.
Positive_regulation (increase) of c-fos
10) Confidence 0.67 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.26
All these techniques induce c-fos within Sp5C and are used as a rodent/feline model of vascular headache in humans.
Positive_regulation (induce) of c-fos associated with headache and increased venous pressure under development
11) Confidence 0.67 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11245884 Disease Relevance 0.68 Pain Relevance 0.92
It is thus possible that dopamine may play a role in eliciting the increased c-fos response seen in the accumbens core in the present study.
Positive_regulation (increased) of c-fos associated with dopamine
12) Confidence 0.67 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.38
Other articles describe the interaction between a 5HT(3) antagonist and CCK-induced satiety and c-fos activation and document secretion of oxytocin and vasopressin in female patients and controls in response to CCK 4 administration.
Positive_regulation (activation) of c-fos associated with antagonist and 5ht
13) Confidence 0.67 Published 2001 Journal Peptides Section Abstract Doc Link 11457511 Disease Relevance 0.17 Pain Relevance 0.34
The large increases in c-fos and Egr1 for permethrin and not deltamethrin are consistent with the microarray data as these two genes were identified as dose-responsive at 6 h for the former and not the latter compound.
Positive_regulation (increases) of c-fos
14) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0.04
Increased neuronal activity (as evidenced by increased c-fos activity) was found primarily in orexin neurons of the tuberomammilary nucleus, even with administration of low doses of modafinil (Scammell et al 2000).
Positive_regulation (increased) of c-fos in neurons
15) Confidence 0.67 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654790 Disease Relevance 0 Pain Relevance 0.29
In addition, AA also increased several AP-1 proteins, such as c-Fos, Fra-1, Fra-2, JunB, JunD, and c-Jun, or AP-1 and ENKCRE-2 DNA-binding activity.
Positive_regulation (increased) of c-Fos
16) Confidence 0.67 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10762717 Disease Relevance 0 Pain Relevance 0
Both the phosphorylation of MAP kinase and the induction of c-Fos were detected by immunoblotting.
Positive_regulation (induction) of c-Fos
17) Confidence 0.67 Published 1999 Journal Anesthesiology Section Body Doc Link 10598624 Disease Relevance 0 Pain Relevance 0
Potentiation by metamizol was also observed as a bilateral decrease in stimulus-evoked c-Fos induction in superficial laminas (I-II) of the dorsal spinal cord after drug combination compared to single administration (66.5 +/- 2.2 vs. 80.7 +/- 4.2; P < 0.05).
Positive_regulation (induction) of c-Fos in laminas associated with spinal cord
18) Confidence 0.67 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698203 Disease Relevance 0.07 Pain Relevance 1.17
Morphine did not stimulate c-fos in the thalamus.
Neg (not) Positive_regulation (stimulate) of c-fos in thalamus associated with thalamus and morphine
19) Confidence 0.67 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9203564 Disease Relevance 0 Pain Relevance 0.43
No effects were seen in alcohol-induced c-Fos after the pretreatment of 20 mg/kg propranolol (beta-adrenoceptor antagonist), 10 mg/kg 2-(2-(4-(2-methoxyphenyl)piperazin-1-yl) ethy)-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride (ARC 239) (alpha(2B/C)-adrenoceptor antagonist), or 30 mg/kg naltrexone (opioid antagonist).
Positive_regulation (induced) of c-Fos associated with aids-related complex, antagonist, opioid and alcohol
20) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130710 Disease Relevance 0.16 Pain Relevance 0.96

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