INT53567

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Context Info
Confidence 0.45
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 11.03
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (FECH) mitochondrion (FECH) small molecule metabolic process (FECH)
Anatomy Link Frequency
HeLa 2
liver 1
erythrocyte 1
bone marrow 1
skin 1
FECH (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 165 99.84 Very High Very High Very High
backache 21 95.08 Very High Very High Very High
tolerance 13 85.68 High High
abdominal pain 2 54.32 Quite High
Chronic low back pain 4 50.00 Quite Low
Bile 8 33.56 Quite Low
fibrosis 8 32.20 Quite Low
Inflammation 16 29.60 Quite Low
burning pain 1 25.00 Low Low
imagery 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erythropoietic Protoporphyria 394 100.00 Very High Very High Very High
Pain 126 99.84 Very High Very High Very High
Sunburn 125 98.88 Very High Very High Very High
Low Back Pain 43 97.68 Very High Very High Very High
Disease 163 97.60 Very High Very High Very High
Porphyria 70 97.12 Very High Very High Very High
Anaemia 83 93.76 High High
Thrombocytopenia 5 92.88 High High
Liver Disease 111 85.20 High High
Syndrome 19 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In EPP, deficient ferrochelatase activity leads to the excessive production and biliary excretion of protoporphyrin (PP).
Positive_regulation (leads) of ferrochelatase associated with erythropoietic protoporphyria
1) Confidence 0.45 Published 2010 Journal Korean J Hepatol Section Abstract Doc Link 20375647 Disease Relevance 1.27 Pain Relevance 0.05
In EPP, deficient ferrochelatase activity leads to the excessive production and biliary excretion of protoporphyrin (PP).
Positive_regulation (leads) of EPP associated with erythropoietic protoporphyria
2) Confidence 0.45 Published 2010 Journal Korean J Hepatol Section Abstract Doc Link 20375647 Disease Relevance 1.27 Pain Relevance 0.05
Erythropoietic protoporphyria (EPP) is an inherited inborn error of porphyrin metabolism caused by decreased activity of the enzyme ferrochelatase, the terminal enzyme of the haem biosynthetic pathway, which catalyses the insertion of iron into protoporphyrin to form haem.
Positive_regulation (activity) of ferrochelatase associated with erythropoietic protoporphyria
3) Confidence 0.43 Published 1994 Journal Br. J. Dermatol. Section Abstract Doc Link 7857832 Disease Relevance 0.52 Pain Relevance 0
It is remarkable that on an average, subjects reported a higher level of pain before undergoing the FCE than 4 days following the FCE.
Positive_regulation (undergoing) of FCE associated with pain
4) Confidence 0.38 Published 2008 Journal J Occup Rehabil Section Body Doc Link PMC2522381 Disease Relevance 0.91 Pain Relevance 0.91
Although the level of protoporphyrin IX, the substrate of ferrochelatase (FECH), was found to be slightly increased (1.33-fold) in ABCB7 knockdown HeLa cells (87), there is no evidence that free protoporphyrin IX accumulates in ABCB7-deficient human patients and mouse models (77,84,86).
Positive_regulation (increased) of ferrochelatase in HeLa
5) Confidence 0.36 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.23 Pain Relevance 0
Although the level of protoporphyrin IX, the substrate of ferrochelatase (FECH), was found to be slightly increased (1.33-fold) in ABCB7 knockdown HeLa cells (87), there is no evidence that free protoporphyrin IX accumulates in ABCB7-deficient human patients and mouse models (77,84,86).
Positive_regulation (increased) of FECH in HeLa
6) Confidence 0.36 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.23 Pain Relevance 0
Finally, because FECH deficiency causes erythropoietic protoporphyria (EPP), manifesting painful skin photosensitivity due to protoporphyrin accumulation (92), and deficient Fe?
Positive_regulation (causes) of EPP in skin associated with pain, sunburn and erythropoietic protoporphyria
7) Confidence 0.34 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.80 Pain Relevance 0.10
All patients underwent an FCE.
Positive_regulation (underwent) of FCE
8) Confidence 0.33 Published 2008 Journal J Occup Rehabil Section Abstract Doc Link PMC2668547 Disease Relevance 0.53 Pain Relevance 0.53
All patients underwent an FCE.
Positive_regulation (underwent) of FCE
9) Confidence 0.32 Published 2006 Journal J Occup Rehabil Section Body Doc Link 16708276 Disease Relevance 0 Pain Relevance 0
Patients were undergoing FCE as part of their usual clinical care.
Positive_regulation (undergoing) of FCE
10) Confidence 0.21 Published 2006 Journal Disabil Rehabil Section Body Doc Link 16966235 Disease Relevance 0.08 Pain Relevance 0
METHODS: Prospective study of 130 claimants undergoing FCE for chronic back problems.
Positive_regulation (undergoing) of FCE
11) Confidence 0.21 Published 2005 Journal J Occup Rehabil Section Body Doc Link 16119221 Disease Relevance 0.19 Pain Relevance 0
Our data show that erythrocyte accumulation of PPIX in EPP patients influences hematologic and iron status.
Positive_regulation (accumulation) of EPP in erythrocyte associated with erythropoietic protoporphyria
12) Confidence 0.12 Published 2009 Journal Cell. Mol. Biol. (Noisy-le-grand) Section Abstract Doc Link 19268001 Disease Relevance 0.95 Pain Relevance 0.08
FECH mutations on both alleles are an uncommon cause of EPP.
Positive_regulation (cause) of EPP associated with erythropoietic protoporphyria
13) Confidence 0.11 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 0.83 Pain Relevance 0
As the experience with liver and bone marrow transplantations in EPP patients increases, rationale for patient selection, indication for transplantation and timing either for bone marrow, liver or sequential transplantations can be established.
Positive_regulation (increases) of EPP in liver associated with erythropoietic protoporphyria
14) Confidence 0.08 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 1.37 Pain Relevance 0.04
EPP clinical manifestations are consequence of protoporphyrin accumulation in various tissues.
Positive_regulation (accumulation) of EPP associated with erythropoietic protoporphyria
15) Confidence 0.08 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 0.47 Pain Relevance 0
As the experience with liver and bone marrow transplantations in EPP patients increases, rationale for patient selection, indication for transplantation and timing either for bone marrow, liver or sequential transplantations can be established.
Positive_regulation (increases) of EPP in bone marrow associated with erythropoietic protoporphyria
16) Confidence 0.03 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2747912 Disease Relevance 1.37 Pain Relevance 0.04

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