INT53572

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Context Info
Confidence 0.40
First Reported 1993
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 12.78
Pain Relevance 6.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 9
plaques 2
platelets 2
apoptotic cells 2
fibroblasts 1
Il1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 241 100.00 Very High Very High Very High
Inflammatory mediators 35 100.00 Very High Very High Very High
Morphine 15 99.98 Very High Very High Very High
cva 6 99.80 Very High Very High Very High
Inflammation 438 99.08 Very High Very High Very High
dexamethasone 5 98.38 Very High Very High Very High
Pain 15 96.56 Very High Very High Very High
Inflammatory response 62 96.36 Very High Very High Very High
Dopamine 61 96.20 Very High Very High Very High
midbrain 5 94.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 546 100.00 Very High Very High Very High
Hemorrhage 5 99.80 Very High Very High Very High
Targeted Disruption 33 99.74 Very High Very High Very High
Sepsis 108 99.68 Very High Very High Very High
Arthritis 34 99.46 Very High Very High Very High
Alzheimer's Dementia 66 99.44 Very High Very High Very High
Endotoxemia 6 99.28 Very High Very High Very High
Apoptosis 100 99.00 Very High Very High Very High
Syndrome 6 98.68 Very High Very High Very High
Crystal Associated Disease 75 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These agents appear to function by blocking the release of TNF alpha and IL-1 from macrophages as well as competition with their respective high affinity receptors on target tissue, eg. fibroblasts, and macrophages.
Negative_regulation (blocking) of Localization (release) of IL-1 in macrophages
1) Confidence 0.40 Published 1996 Journal Biomed. Pharmacother. Section Abstract Doc Link 8952870 Disease Relevance 0.36 Pain Relevance 0.25
In Down's syndrome, where patients are predisposed to AD neuropathological changes, IL-1 elevation and neuroinflammation precede by years the formation of plaques [119].
Negative_regulation (precede) of Localization (elevation) of IL-1 in plaques associated with syndrome and alzheimer's dementia
2) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.47 Pain Relevance 0.07
In part they appear to mediate their effects due to their ability to suppress the release of cytokines such as TNF alpha and IL-1 from macrophages, as well as the binding of these cytokines to high-affinity receptors on target cells involved in the inflammation process.
Negative_regulation (suppress) of Localization (release) of IL-1 in macrophages associated with inflammation and cytokine
3) Confidence 0.35 Published 1996 Journal Int J Tissue React Section Abstract Doc Link 9063766 Disease Relevance 0.45 Pain Relevance 0.33
In part, the ability of these agents to suppress the inflammatory process is due to their blockage of cytokine release, e.g.TNF alpha and IL-1, as well as their inhibition of high affinity binding to receptors on target cells of inflammation.
Negative_regulation (inhibition) of Localization (release) of IL-1 associated with inflammation and cytokine
4) Confidence 0.35 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687282 Disease Relevance 0.55 Pain Relevance 0.36
Paradoxically, an alternative mechanism of protection of prophylactic heat treatments could be to decrease the amount of IL-1 and TNF released during sepsis or endotoxemia.
Negative_regulation (decrease) of Localization (released) of IL-1 associated with endotoxemia and sepsis
5) Confidence 0.34 Published 1994 Journal Lymphokine Cytokine Res. Section Abstract Doc Link 7858059 Disease Relevance 0.88 Pain Relevance 0.18
In contrast, morphine reduction of splenic and thymic cell number and mitogen-induced proliferation were unaffected in MOR-KO mice, as was morphine inhibition of IL-1 and IL-6 secretion by macrophages.
Negative_regulation (inhibition) of Localization (secretion) of IL-1 in macrophages associated with morphine
6) Confidence 0.30 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9795212 Disease Relevance 0.16 Pain Relevance 1.00
Hemorrhage markedly decreased the ability of pMphi and sMphi to release IL-1 and IL-6.
Negative_regulation (decreased) of Localization (release) of IL-1 associated with cva
7) Confidence 0.22 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
A glucocorticoid (dexamethasone), two cyclooxygenase inhibitors (indomethacin, piroxicam) and an interleukin-1 (IL-1) release inhibitor (IX 207-887, Sandoz) all reduced edema and MPO activity as well.
Negative_regulation (inhibitor) of Localization (release) of IL-1 associated with pressure and volume under development, urological neuroanatomy and dexamethasone
8) Confidence 0.17 Published 1993 Journal Agents Actions Section Abstract Doc Link 8304241 Disease Relevance 0.97 Pain Relevance 0.47
Bone-marrow-derived macrophages from CD14 knockout mice showed reduced secretion of IL-1?
Negative_regulation (reduced) of Localization (secretion) of IL-1 in macrophages associated with targeted disruption
9) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.40 Pain Relevance 0.43
These agents appear to function by blocking the release of TNF alpha and IL-1 from macrophages as well as competition with their respective high affinity receptors on target tissue, eg. fibroblasts, and macrophages.
Negative_regulation (blocking) of in fibroblasts Localization (release) of IL-1 in macrophages
10) Confidence 0.14 Published 1996 Journal Biomed. Pharmacother. Section Abstract Doc Link 8952870 Disease Relevance 0.36 Pain Relevance 0.25
The latter approaches will provide limited specificity for IL-18 since generation and release of other IL-1 superfamily members may also be inhibited.
Negative_regulation (inhibited) of Localization (release) of IL-1
11) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.15 Pain Relevance 0.24
These compounds can suppress antigen and mitogen-induced lymphocyte proliferation, natural-killer cell cytotoxicity, histamine release by mast cells, interleukin-1 (IL-1) secretion by human monocytes and the action of PAF on platelets [47].
Negative_regulation (suppress) of Localization (secretion) of IL-1 in platelets
12) Confidence 0.08 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2810220 Disease Relevance 0.83 Pain Relevance 0.42
Moreover, direct application of IL-1?
Negative_regulation (direct) of Localization (application) of IL-1
13) Confidence 0.08 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.47 Pain Relevance 0.57
Finally, as compounds such as Tenidap, which is being evaluated for its anti-inflammatory and anti-arthritic properties also appear to inhibit the release of IL-1?
Negative_regulation (inhibit) of Localization (release) of IL-1 associated with inflammation and arthritis
14) Confidence 0.04 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 0.49 Pain Relevance 0.21
Furthermore, phagocytosis of apoptotic cells, unlike other particles, has been shown to inhibit the release of pro-inflammatory mediators including IL-1?
Negative_regulation (inhibit) of Localization (release) of IL-1 in apoptotic cells associated with inflammatory mediators and apoptosis
15) Confidence 0.03 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1838907 Disease Relevance 2.07 Pain Relevance 0.32
Acetylcholine attenuates the release of proinflammatory cytokines (TNF, IL-1?
Negative_regulation (attenuates) of Localization (release) of IL-1 associated with cytokine
16) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.83 Pain Relevance 0.89
A water-soluble derivative (sodium sulphonate) of tanshinone
           IIA (TSN IIA-SS) at concentrations (100 µm) that completely
           abrogated LPS-induced HMGB1 release, only partially attenuated LPS-induced release of
           four out of 62 cytokines (IL-12p70, IL-1?
Negative_regulation (attenuated) of Localization (release) of IL-1 associated with cytokine
17) Confidence 0.02 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.41 Pain Relevance 0.24
Moreover, inhibition of panx1 not only inhibited caspase-1-dependent processing and release of both IL-1?
Negative_regulation (inhibited) of Localization (release) of IL-1
18) Confidence 0.02 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.14 Pain Relevance 0.08

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