INT53573

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 11.57
Pain Relevance 8.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
macrophages 7
neurons 2
dendritic cells 2
melanocyte 2
keratinocyte 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 44 100.00 Very High Very High Very High
chemokine 9 100.00 Very High Very High Very High
antagonist 14 99.98 Very High Very High Very High
Inflammation 152 99.82 Very High Very High Very High
Infliximab 2 99.76 Very High Very High Very High
Paracetamol 17 99.32 Very High Very High Very High
Dopamine 1 99.32 Very High Very High Very High
Opioid 10 99.00 Very High Very High Very High
narcan 20 98.64 Very High Very High Very High
agonist 8 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 27 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
INFLAMMATION 155 99.82 Very High Very High Very High
Fever 10 99.34 Very High Very High Very High
Hyperalgesia 7 98.24 Very High Very High Very High
Sepsis 8 97.24 Very High Very High Very High
Hepatotoxicity 3 96.96 Very High Very High Very High
Death 3 96.92 Very High Very High Very High
Endotoxemia 4 96.84 Very High Very High Very High
Pain 8 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lycopene also inhibited the TNF-alpha and NO release in a dose dependent manner.
Negative_regulation (inhibited) of Localization (release) of TNF-alpha
1) Confidence 0.59 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18055235 Disease Relevance 1.30 Pain Relevance 0.73
Pretreatment of cultures with naloxone (1 microM) followed by treatment with lipopolysaccharide significantly inhibited the lipopolysaccharide-induced production of nitric oxide and the release of tumor necrosis factor-alpha, and significantly reduced the lipopolysaccharide-induced damage to neurons.
Negative_regulation (inhibited) of Localization (release) of tumor necrosis factor-alpha in neurons associated with necrosis, cancer and narcan
2) Confidence 0.58 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842020 Disease Relevance 0.41 Pain Relevance 0.53
These agents appear to function by blocking the release of TNF alpha and IL-1 from macrophages as well as competition with their respective high affinity receptors on target tissue, eg. fibroblasts, and macrophages.
Negative_regulation (blocking) of Localization (release) of TNF alpha in macrophages
3) Confidence 0.55 Published 1996 Journal Biomed. Pharmacother. Section Abstract Doc Link 8952870 Disease Relevance 0.36 Pain Relevance 0.25
The concomitant administration of pentoxifylline (decreasing TNF-alpha secretion) and infliximab (trapping TNF-alpha) likewise attenuated the Jo2-mediated increase in TNF-alpha, the decrease in hepatic glutathione, and the increase in serum ALT activity 5 h after Jo2 administration.
Negative_regulation (decreasing) of Localization (secretion) of TNF-alpha associated with infliximab
4) Confidence 0.55 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18572215 Disease Relevance 0.59 Pain Relevance 0.20
In part they appear to mediate their effects due to their ability to suppress the release of cytokines such as TNF alpha and IL-1 from macrophages, as well as the binding of these cytokines to high-affinity receptors on target cells involved in the inflammation process.
Negative_regulation (suppress) of Localization (release) of TNF alpha in macrophages associated with inflammation and cytokine
5) Confidence 0.48 Published 1996 Journal Int J Tissue React Section Abstract Doc Link 9063766 Disease Relevance 0.45 Pain Relevance 0.33
Curcumin also inhibited the TNF-alpha and NO release in a dose dependent manner.
Negative_regulation (inhibited) of Localization (release) of TNF-alpha
6) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16584726 Disease Relevance 1.28 Pain Relevance 0.73
IL-4, -10, or -13 significantly inhibited the release of both tumor necrosis factor (TNF)-alpha (60, 53, and 100%, respectively) and IL-1beta (80, 100, and 100%, respectively) by mice peritoneal macrophages obtained after local (i.p.) injection of zymosan.
Negative_regulation (inhibited) of Localization (release) of tumor necrosis factor in peritoneal macrophages associated with necrosis and cancer
7) Confidence 0.42 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490580 Disease Relevance 0.37 Pain Relevance 0.79
Budlein A also inhibited the carrageenan-induced release of TNF-alpha (52%), KC (70%) and IL-1beta (59%).
Negative_regulation (inhibited) of Localization (release) of TNF-alpha
8) Confidence 0.39 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320857 Disease Relevance 0.71 Pain Relevance 0.47
Neutralization of TNF-alpha or IL-1 alpha with specific antibodies partially prevented the hepatotoxic effects of APAP at the 4- and 8-hr time points.
Negative_regulation (prevented) of Localization (Neutralization) of TNF-alpha associated with paracetamol
9) Confidence 0.37 Published 1996 Journal Toxicol Pathol Section Abstract Doc Link 8992608 Disease Relevance 0.73 Pain Relevance 0.84
When murine J774 macrophages were incubated with the sesquiterpene lactone, LPS-induced IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and keratinocyte-derived chemokine (KC) release were concentration-dependently inhibited.
Negative_regulation (inhibited) of Localization (release) of TNF-alpha in keratinocyte associated with chemokine, necrosis and cancer
10) Confidence 0.37 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.65 Pain Relevance 0.40
In part, the ability of these agents to suppress the inflammatory process is due to their blockage of cytokine release, e.g.TNF alpha and IL-1, as well as their inhibition of high affinity binding to receptors on target cells of inflammation.
Negative_regulation (inhibition) of Localization (release) of TNF alpha associated with inflammation and cytokine
11) Confidence 0.35 Published 1996 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 8687282 Disease Relevance 0.55 Pain Relevance 0.36
Macrophage cultures from CLP animals incubated with either epinephrine or IL-10 for 2 h had significantly reduced TNF-alpha and IL-6 release in response to LPS.
Negative_regulation (reduced) of Localization (release) of TNF-alpha in Macrophage
12) Confidence 0.33 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15151906 Disease Relevance 0.30 Pain Relevance 0.34
Moreover, B(1) but not B(2) kinin receptor antagonist inhibited carrageenin-induced hypernociception, and TNF-alpha and IL-1beta release as well, in LPS-primed mice.
Negative_regulation (inhibited) of Localization (release) of TNF-alpha associated with antagonist
13) Confidence 0.32 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17669394 Disease Relevance 0.35 Pain Relevance 0.72
Hyperthermia induces IL-1 alpha but does not decrease release of IL-1 alpha or TNF-alpha after endotoxin.
Neg (not) Negative_regulation (decrease) of Localization (release) of TNF-alpha associated with fever
14) Confidence 0.25 Published 1994 Journal Lymphokine Cytokine Res. Section Title Doc Link 7858059 Disease Relevance 0.87 Pain Relevance 0.21
It has been observed that kappa-opioid drugs exert a powerful anti-inflammatory effect, reducing TNF-alpha release and expression, among other actions [34].
Negative_regulation (reducing) of Localization (release) of TNF-alpha associated with inflammation and opioid
15) Confidence 0.20 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.96 Pain Relevance 0.64
These agents appear to function by blocking the release of TNF alpha and IL-1 from macrophages as well as competition with their respective high affinity receptors on target tissue, eg. fibroblasts, and macrophages.
Negative_regulation (blocking) of in fibroblasts Localization (release) of TNF alpha in macrophages
16) Confidence 0.19 Published 1996 Journal Biomed. Pharmacother. Section Abstract Doc Link 8952870 Disease Relevance 0.36 Pain Relevance 0.25
In this regard, it has been reported that ent-kaurene diterpenes inhibit the expression of inducible nitric oxide synthase (iNOS) and the release of tumor necrosis factor-alpha (TNF-?).
Negative_regulation (inhibit) of Localization (release) of tumor necrosis factor-alpha associated with necrosis and cancer
17) Confidence 0.11 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959212 Disease Relevance 0.78 Pain Relevance 0.32
The inhibitory efficacy of 154N-5 on TNF-alpha secretion in both models was similar to the nonselective agonist NDP-alpha-melanocyte stimulating hormone (NDP-alphaMSH), thus, we conclude that inhibition of TNF-alpha secretion by melanocortin peptides is mediated by MC1R. 154N-5 is a valuable new tool for the evaluation of specific contribution of MC1R agonism to physiological and pathological processes.
Negative_regulation (inhibition) of Localization (secretion) of TNF-alpha in melanocyte associated with pathologic processes and agonist
18) Confidence 0.09 Published 2003 Journal Peptides Section Abstract Doc Link 12895657 Disease Relevance 0.28 Pain Relevance 0.29
Furthermore, MSCs not only have a direct inhibitory effect on T cells but also affect the first critical step of immune response in that they can inhibit the differentiation and maturation of the antigen-presenting cells and cause the dendritic cells to switch cytokine secretion profile to decrease their secretion of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-?)
Negative_regulation (decrease) of Localization (secretion) of tumor necrosis factor-alpha in dendritic cells associated with necrosis, cancer and cytokine
19) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.27 Pain Relevance 0.18

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