INT53574

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2011
Negated 2
Speculated 5
Reported most in Abstract
Documents 45
Total Number 50
Disease Relevance 40.68
Pain Relevance 19.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
liver 3
neural 3
hepatocytes 2
spinal cord 1
brain 1
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 235 100.00 Very High Very High Very High
cytokine 115 100.00 Very High Very High Very High
chemokine 43 100.00 Very High Very High Very High
Pain 23 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
neuralgia 9 100.00 Very High Very High Very High
spinal inflammation 15 99.84 Very High Very High Very High
Spinal cord 14 99.84 Very High Very High Very High
Neuropathic pain 14 99.60 Very High Very High Very High
psoriasis 2 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 265 100.00 Very High Very High Very High
Necrosis 59 100.00 Very High Very High Very High
Cancer 58 100.00 Very High Very High Very High
Adhesions 6 100.00 Very High Very High Very High
Rheumatoid Arthritis 20 99.84 Very High Very High Very High
Low Back Pain 15 99.84 Very High Very High Very High
Pain 10 99.84 Very High Very High Very High
Wallerian Degeneration 32 99.68 Very High Very High Very High
Neuropathic Pain 31 99.60 Very High Very High Very High
Psoriasis 2 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice.
Regulation (regulation) of tumor necrosis factor-alpha in spinal cord associated with vincristine, necrosis, allodynia, cancer and spinal cord
1) Confidence 0.62 Published 2008 Journal Neurosci. Lett. Section Title Doc Link 18790011 Disease Relevance 0.81 Pain Relevance 1.02
OBJECTIVES: The purpose of the current study was to evaluate changes in tumor necrosis factor-alpha (TNF-alpha ) and TNF-alpha receptor 1 (p55 receptor) using double fluorescent immunohistochemistry in glial and neural cells in the dorsal root ganglion and spinal cord after sciatic nerve injury in mice.
Regulation (changes) of tumor necrosis factor-alpha in neural associated with ganglion cysts, dorsal root ganglion, necrosis, nervous system injury, cancer, sciatic nerve and spinal cord
2) Confidence 0.60 Published 2004 Journal Spine Section Abstract Doc Link 15131433 Disease Relevance 0.61 Pain Relevance 0.32
Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve.
Regulation (regulated) of Tumor necrosis factor in sciatic nerve associated with necrosis, neuralgia, wallerian degeneration and sciatic nerve
3) Confidence 0.60 Published 2005 Journal Exp. Neurol. Section Title Doc Link 15698630 Disease Relevance 1.16 Pain Relevance 0.67
No IL-1beta or TNF-alpha response was observed at any time point in either exposure model.
Neg (No) Regulation (response) of TNF-alpha
4) Confidence 0.60 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 0.85 Pain Relevance 0.47
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.
Regulation (regulating) of tumor necrosis factor-alpha in hepatocytes associated with toxicity, necrosis, paracetamol and cancer
5) Confidence 0.54 Published 2010 Journal J Toxicol Sci Section Title Doc Link 20371967 Disease Relevance 1.42 Pain Relevance 0.85
MKGS also affected the levels of IL-1beta, TNF-alpha and NO induced by lambda-carrageenan.
Regulation (affected) of TNF-alpha in MKGS
6) Confidence 0.52 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503470 Disease Relevance 1.04 Pain Relevance 0.57
We presently document the involvement of the inflammatory cytokines TNFalpha, interleukin (IL)-1alpha, and IL-1beta in peripheral nerve (PNS) injury in C57/BL/6NHSD (C57/BL) mice that display the normal rapid progression of WD (rapid-WD) and C57/BL/6-WLD/OLA/NHSD mice that display abnormal slow progression of WD (slow-WD).
Regulation (involvement) of TNFalpha in PNS associated with inflammation, injury, wallerian degeneration and cytokine
7) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.37 Pain Relevance 0.28
Effects of TNF-alpha or Leu-Ile on MOR-induced antinociceptive effect and withdrawal symptoms were examined by hot plate test and naloxone-precipitated withdrawal.
Regulation (Effects) of TNF-alpha
8) Confidence 0.45 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17217924 Disease Relevance 0 Pain Relevance 0
Effects of TNF-alpha or Leu-Ile on MOR-induced rewarding effects and sensitization were investigated by conditioned place preference and locomotor activity tests.
Regulation (Effects) of TNF-alpha
9) Confidence 0.45 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17217924 Disease Relevance 0 Pain Relevance 0
These results suggest that VCR treatments elicited the activation of glial cells in spinal cord, and up-regulated TNF-alpha in these cells may play an important role in VCR-induced mechanical allodynia.
Regulation (regulated) of TNF-alpha in glial cells associated with vincristine, allodynia and spinal cord
10) Confidence 0.45 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18790011 Disease Relevance 0.72 Pain Relevance 1.05
To evaluate the role of opiate receptors, we studied the effect of naloxone and naltrexone on mesangial cell TNF-alpha and nitrite production.
Regulation (effect) of TNF-alpha in mesangial cell
11) Confidence 0.45 Published 2000 Journal Inflammation Section Body Doc Link 10921509 Disease Relevance 0.17 Pain Relevance 0
The results suggest that the persistent thermal, and especially the persistent mechanical, hypernociception observed following BPA in mice is largely dependent on the generation of TNFalpha.
Regulation (dependent) of TNFalpha
12) Confidence 0.45 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16386767 Disease Relevance 0.59 Pain Relevance 0.27
Registry data confirm that TNFalpha antagonist therapy is effective in RA.
Regulation (effective) of TNFalpha associated with antagonist and rheumatoid arthritis
13) Confidence 0.45 Published 2010 Journal Joint Bone Spine Section Abstract Doc Link 20554241 Disease Relevance 0.66 Pain Relevance 0.35
Effects of neutralizing antibodies to TNF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury.
Regulation (Effects) of TNF-alpha in nerve associated with pain, eae and injury
14) Confidence 0.45 Published 2000 Journal Brain Res. Section Title Doc Link 10825476 Disease Relevance 1.13 Pain Relevance 1.13
The beneficial or detrimental roles of these cytokines, including interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha), remain to be clarified.
Regulation (roles) of tumor necrosis factor alpha associated with necrosis, cancer and cytokine
15) Confidence 0.45 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399681 Disease Relevance 0.51 Pain Relevance 0.18
The beneficial or detrimental roles of these cytokines, including interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha), remain to be clarified.
Regulation (roles) of TNF-alpha associated with necrosis, cancer and cytokine
16) Confidence 0.45 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399681 Disease Relevance 0.51 Pain Relevance 0.18
OBJECTIVES: The purpose of the current study was to evaluate changes in tumor necrosis factor-alpha (TNF-alpha ) and TNF-alpha receptor 1 (p55 receptor) using double fluorescent immunohistochemistry in glial and neural cells in the dorsal root ganglion and spinal cord after sciatic nerve injury in mice.
Regulation (changes) of TNF-alpha in neural associated with ganglion cysts, dorsal root ganglion, necrosis, nervous system injury, cancer, sciatic nerve and spinal cord
17) Confidence 0.44 Published 2004 Journal Spine Section Abstract Doc Link 15131433 Disease Relevance 0.62 Pain Relevance 0.33
In this study, we used two different HD exposure models to determine the in vivo cutaneous response of the inflammatory cytokines interleukin-6 (IL-6), IL-1alpha, IL-1beta and tumor necrosis factor alpha (TNF-alpha), in order to identify a suitable inflammatory biomarker common to both models.
Regulation (response) of tumor necrosis factor associated with necrosis, inflammation, cancer and cytokine
18) Confidence 0.44 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 1.04 Pain Relevance 0.44
In this study, we used two different HD exposure models to determine the in vivo cutaneous response of the inflammatory cytokines interleukin-6 (IL-6), IL-1alpha, IL-1beta and tumor necrosis factor alpha (TNF-alpha), in order to identify a suitable inflammatory biomarker common to both models.
Regulation (response) of TNF-alpha associated with necrosis, inflammation, cancer and cytokine
19) Confidence 0.44 Published 2000 Journal J Appl Toxicol Section Abstract Doc Link 11428647 Disease Relevance 1.05 Pain Relevance 0.46
In this work, we studied the role of changes in norepinephrine (NE) level on the lipopolysaccharide (LPS) evoked tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 response both in the plasma and in the hippocampus of mice.
Regulation (response) of tumor necrosis factor in hippocampus associated with necrosis, cancer and hippocampus
20) Confidence 0.44 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17584982 Disease Relevance 0.68 Pain Relevance 0.66

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