INT53575

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2010
Negated 8
Speculated 8
Reported most in Abstract
Documents 46
Total Number 54
Disease Relevance 34.35
Pain Relevance 20.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
macrophages 14
liver 8
brains 4
lungs 4
peritoneal macrophages 4
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 159 100.00 Very High Very High Very High
cytokine 104 100.00 Very High Very High Very High
Paracetamol 52 100.00 Very High Very High Very High
Morphine 32 100.00 Very High Very High Very High
cINOD 13 100.00 Very High Very High Very High
narcan 11 100.00 Very High Very High Very High
Inflammatory response 10 100.00 Very High Very High Very High
methotrexate 2 99.88 Very High Very High Very High
headache 1 99.88 Very High Very High Very High
qutenza 15 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 181 100.00 Very High Very High Very High
Necrosis 66 100.00 Very High Very High Very High
Cancer 54 100.00 Very High Very High Very High
Adhesions 13 100.00 Very High Very High Very High
Urological Neuroanatomy 26 99.84 Very High Very High Very High
Juvenile Chronic Polyarthritis 1 99.84 Very High Very High Very High
Stress 17 99.76 Very High Very High Very High
Viral Meningitis 16 99.76 Very High Very High Very High
Injury 36 99.32 Very High Very High Very High
Frailty 8 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is not known if TNF-alpha expression is altered in the ACC in response to persistent pain and if synaptic transmission within this region is modulated by TNF-alpha.
Regulation (altered) of Gene_expression (expression) of TNF-alpha in ACC associated with pain, lasting pain and anterior cingulate cortex
1) Confidence 0.62 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17222972 Disease Relevance 0.76 Pain Relevance 0.77
The aim of our study was to clarify the effect of morphine on lipopolysaccharide (LPS)-induced TNF-alpha production in vivo.
Regulation (effect) of Gene_expression (production) of TNF-alpha associated with morphine
2) Confidence 0.62 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.57
Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system.
Regulation (Effect) of Gene_expression (production) of tumor necrosis factor-alpha in sympathetic nervous system associated with necrosis, cancer, narcan and morphine
3) Confidence 0.62 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9058753 Disease Relevance 0.45 Pain Relevance 0.76
Spinal and supraspinal changes in tumor necrosis factor-alpha expression following excitotoxic spinal cord injury.
Regulation (changes) of in spinal cord Gene_expression (expression) of tumor necrosis factor-alpha in Spinal associated with pain, necrosis, cancer and spinal cord
4) Confidence 0.62 Published 2007 Journal J. Mol. Neurosci. Section Title Doc Link 17416966 Disease Relevance 1.19 Pain Relevance 0.38
To evaluate the role of opiate receptors, we studied the effect of naloxone and naltrexone on mesangial cell TNF-alpha and nitrite production.
Regulation (effect) of Gene_expression (production) of TNF-alpha in mesangial cell
5) Confidence 0.62 Published 2000 Journal Inflammation Section Body Doc Link 10921509 Disease Relevance 0.17 Pain Relevance 0
In conclusion, there is no evidence to suggest that modulation of TNFalpha expression affects hepatic injury following experimental paracetamol poisoning; anti-TNFalpha therapies are therefore unlikely to be effective in the corresponding clinical situation.
Regulation (modulation) of Gene_expression (expression) of TNFalpha associated with paracetamol, injury and poisoning
6) Confidence 0.61 Published 2000 Journal J. Pathol. Section Abstract Doc Link 10700000 Disease Relevance 0.75 Pain Relevance 0.62
There was a significant increase in serum TNFalpha at 6 h (control 0.002+/-0.002 ng/ml, n=7; paracetamol-treated 0.022+/-0.007 ng/ml, n=5, p<0.05), but hepatic TNFalpha expression did not change up to 24 h following paracetamol injection.
Neg (not) Regulation (change) of Gene_expression (expression) of TNFalpha associated with paracetamol
7) Confidence 0.61 Published 2000 Journal J. Pathol. Section Abstract Doc Link 10700000 Disease Relevance 1.01 Pain Relevance 0.77
By using alpha2- and beta-adrenergic drugs (clonidine, CH-38083, isoproterenol, propranolol) we provided the first in vivo evidence that, beside the dominance of neuronal alpha2- and macrophage beta-adrenoceptors, the alpha2-adrenoceptors on macrophages were also involved in the modulation of LPS-induced TNF-alpha production.
Regulation (modulation) of Gene_expression (production) of TNF-alpha in macrophage associated with clonidine
8) Confidence 0.61 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10674987 Disease Relevance 0.14 Pain Relevance 0.14
Our objective was to characterize the molecular mechanisms responsible for the hepatic inflammatory response to time-limited TNF-alpha and IL-1beta expression.
Regulation (responsible) of Gene_expression (expression) of TNF-alpha associated with inflammatory response
9) Confidence 0.54 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.29 Pain Relevance 0.22
When bone marrow-derived, splenic or peritoneal macrophages were treated with LPS in vitro, administration of naltrexone had no direct effect on TNF-alpha production.
Neg (no) Regulation (effect) of Gene_expression (production) of TNF-alpha in peritoneal macrophages
10) Confidence 0.54 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15265541 Disease Relevance 0.69 Pain Relevance 0.58
Effect of morphine on interleukin-1 and tumor necrosis factor alpha production from mouse peritoneal macrophages in vitro.
Regulation (Effect) of Gene_expression (production) of tumor necrosis factor alpha in peritoneal macrophages associated with necrosis, cancer, narcan and morphine
11) Confidence 0.53 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 8701766 Disease Relevance 0.20 Pain Relevance 0.25
A compound preparation of traditional Chinese medicine inhibited eotaxin mRNA and eosinophil infiltration, influenced TNF-alpha mRNA expression.
Regulation (influenced) of Gene_expression (expression) of TNF-alpha mRNA in eosinophil
12) Confidence 0.50 Published 2003 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 12970926 Disease Relevance 0 Pain Relevance 0
Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.
Regulation (effect) of Gene_expression (production) of TNFalpha associated with paracetamol
13) Confidence 0.48 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.19 Pain Relevance 1.25
Blockade of the sympathetic transmission by chlorisondamine prevented the inhibitory effect of morphine on TNF-alpha production.
Regulation (effect) of Gene_expression (production) of TNF-alpha in sympathetic associated with morphine
14) Confidence 0.45 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058753 Disease Relevance 0.39 Pain Relevance 0.77
Thereafter, recruited macrophages contributed to the production of TNFalpha, IL-1alpha, and IL-1beta, which in turn augmented myelin phagocytosis by macrophages.
Regulation (contributed) of Gene_expression (production) of TNFalpha in macrophages
15) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.55 Pain Relevance 0.35
TNF-alpha and IL-1beta production in the supernatant were, on average, 30% lower in the ispilateral group than in the contralateral group.
Regulation (lower) of Gene_expression (production) of TNF-alpha
16) Confidence 0.45 Published 2005 Journal Br J Anaesth Section Body Doc Link 15863437 Disease Relevance 0 Pain Relevance 0
The results corroborated the stimulation of TNF alpha production by NSAIDs (indomethacin, naproxen, ibuprofen) and indicated that the stimulation rank-ordered with the potency of inhibition of PGHS-1.
Regulation (stimulation) of Gene_expression (production) of TNF alpha associated with cinod and potency
17) Confidence 0.44 Published 1993 Journal Drugs Exp Clin Res Section Abstract Doc Link 8013267 Disease Relevance 0.71 Pain Relevance 0.67
Tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, lipopolysaccharide binding protein (LBP) and CD14 mRNA (messenger ribonucleic acid) expression in mouse liver were determined by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) analysis. 3.
Spec (determined) Regulation (determined) of Gene_expression (expression) of Tumor necrosis factor in liver associated with necrosis and cancer
18) Confidence 0.44 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 1.13 Pain Relevance 0.15
METHODS: To measure the effects of met-enk on NK activity, the production and gene expression of anti-tumor cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-12 (IL-12) in vitro and in vivo.
Regulation (effects) of Gene_expression (expression) of tumor necrosis factor
19) Confidence 0.44 Published 1996 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 9772675 Disease Relevance 0 Pain Relevance 0
Conversely, PAG had no effect on LPS-induced production of the hypernociceptive cytokines, TNF-alpha, IL-1beta and CXCL1/KC and on hypernociception induced by PGE(2), a directly acting hypernociceptive mediator.
Neg (no) Regulation (effect) of Gene_expression (production) of TNF-alpha associated with urological neuroanatomy and cytokine
20) Confidence 0.44 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18585702 Disease Relevance 0.51 Pain Relevance 0.12

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