INT53577

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 110
Total Number 112
Disease Relevance 59.28
Pain Relevance 35.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 21
PBMC 14
monocytes 9
blood 8
THP-1 6
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1264 100.00 Very High Very High Very High
cytokine 1153 100.00 Very High Very High Very High
Morphine 95 100.00 Very High Very High Very High
fluoxetine 94 99.98 Very High Very High Very High
Paracetamol 19 99.98 Very High Very High Very High
narcan 13 99.98 Very High Very High Very High
dexamethasone 63 99.90 Very High Very High Very High
corticosteroid 31 99.76 Very High Very High Very High
Desipramine 98 99.68 Very High Very High Very High
rheumatoid arthritis 610 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1333 100.00 Very High Very High Very High
Cancer 207 100.00 Very High Very High Very High
Necrosis 141 100.00 Very High Very High Very High
Adhesions 41 100.00 Very High Very High Very High
Nasal Polyps 1 100.00 Very High Very High Very High
Cv General 4 Under Development 219 99.92 Very High Very High Very High
Stress 51 99.78 Very High Very High Very High
Sepsis 389 99.68 Very High Very High Very High
Rheumatoid Arthritis 613 99.60 Very High Very High Very High
Disease 448 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-cancer effects of morphine through inhibition of tumour necrosis factor-alpha release and mRNA expression.
Negative_regulation (inhibition) of Localization (release) of tumour necrosis factor-alpha associated with necrosis, cancer and morphine
1) Confidence 0.59 Published 1996 Journal Carcinogenesis Section Title Doc Link 8968046 Disease Relevance 1.12 Pain Relevance 0.79
Pretreatment of PBMC cultures for 1 h with naloxone blocked (P < 0.05) the inhibitory effect of morphine on the release of TNF upon stimulation with phytohemagglutinin, but not with lipopolysaccharide, suggesting the involvement of an opioid receptor.
Negative_regulation (blocked) of Localization (release) of TNF in PBMC associated with narcan, opioid receptor and morphine
2) Confidence 0.59 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8389331 Disease Relevance 0.15 Pain Relevance 0.92
Morphine inhibits the release of tumor necrosis factor in human peripheral blood mononuclear cell cultures.
Negative_regulation (inhibits) of Localization (release) of tumor necrosis factor in blood associated with necrosis, cancer and morphine
3) Confidence 0.59 Published 1993 Journal Int. J. Immunopharmacol. Section Title Doc Link 8389331 Disease Relevance 0.20 Pain Relevance 0.91
The reduction of tumor necrosis factor-alpha (TNF-alpha) release from LPS-stimulated human monocytic cell line (THP-1) was also demonstrated in cells that were pre-incubated with the extract.
Negative_regulation (reduction) of Localization (release) of TNF-alpha in THP-1 associated with necrosis and cancer
4) Confidence 0.59 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16831527 Disease Relevance 1.15 Pain Relevance 0.38
When isoproterenol and LPS were simultaneously added to the culture medium release of TNF-alpha was reduced by 87 per cent to 82 +/- 40 pg/mg tissue (P < 0.05 vs LPS alone).
Negative_regulation (reduced) of Localization (release) of TNF-alpha
5) Confidence 0.59 Published 2000 Journal Am Surg Section Abstract Doc Link 11261622 Disease Relevance 0.15 Pain Relevance 0.11
Isoproterenol inhibits bacterial lipopolysaccharide-stimulated release of tumor necrosis factor-alpha from human heart tissue.
Negative_regulation (inhibits) of Localization (release) of tumor necrosis factor-alpha in heart associated with necrosis and cancer
6) Confidence 0.59 Published 2000 Journal Am Surg Section Title Doc Link 11261622 Disease Relevance 0.94 Pain Relevance 0.27
Regarding regulation of production, isoproterenol elevates cyclic AMP and inhibits TNF-alpha release in macrophages.
Negative_regulation (inhibits) of Localization (release) of TNF-alpha in macrophages
7) Confidence 0.59 Published 2000 Journal Am Surg Section Abstract Doc Link 11261622 Disease Relevance 0.85 Pain Relevance 0.26
The drugs were unable to abrogate Interleukin 1 and Tumor Necrosis Factor alpha release by activated mononuclear cells.
Neg (unable) Negative_regulation (abrogate) of Localization (release) of Tumor Necrosis Factor alpha in mononuclear cells associated with necrosis and cancer
8) Confidence 0.57 Published 1994 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 7881628 Disease Relevance 0.68 Pain Relevance 0.34
Histamine, PGD(2) and TNFalpha release, immunologically induced by canine anti-IgE, were significantly inhibited in the presence of PEA.
Negative_regulation (inhibited) of Localization (release) of TNFalpha
9) Confidence 0.57 Published 2010 Journal Vet. Immunol. Immunopathol. Section Abstract Doc Link 19625089 Disease Relevance 0.41 Pain Relevance 0.18
We show here that NCX4016 did not significantly reduce the release of TNF?.
Neg (not) Negative_regulation (reduce) of Localization (release) of TNF
10) Confidence 0.57 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.14 Pain Relevance 0.36
It inhibits the secretion of TNF?
Negative_regulation (inhibits) of Localization (secretion) of TNF
11) Confidence 0.57 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.76 Pain Relevance 0.19
Within the Beijing lineage, it has been demonstrated that the phenolic glycolipid (PGL), a product of the pks15 gene product, inhibits secretion of TNF-?
Negative_regulation (inhibits) of Localization (secretion) of TNF
12) Confidence 0.57 Published 2010 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2984234 Disease Relevance 0.76 Pain Relevance 0
M), but was shown to inhibit the release of TNF?
Negative_regulation (inhibit) of Localization (release) of TNF
13) Confidence 0.57 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.12 Pain Relevance 0.34
Comparable to PBT, Gal-4 reduced the secretion of TNF-?
Negative_regulation (reduced) of Localization (secretion) of TNF
14) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0 Pain Relevance 0.17
The possibility of diminished release of TNF?
Negative_regulation (diminished) of Localization (release) of TNF
15) Confidence 0.57 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.09 Pain Relevance 0.19
Similarly, ATP inhibits LPS-induced release of TNF?
Negative_regulation (inhibits) of Localization (release) of TNF
16) Confidence 0.57 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.18
Choline 100 mM reduced binding of alpha-bungarotoxin to macrophages by 72% and decreased their release of TNF by up to 51 (sd 11)%.
Negative_regulation (decreased) of Localization (release) of TNF in macrophages
17) Confidence 0.56 Published 2010 Journal Br J Anaesth Section Body Doc Link 20511332 Disease Relevance 0.07 Pain Relevance 0
Finally, R,R-glycopyrrolate was most effective in the triple combination with budesonide and rolipram in the reduction of TNF-alpha release.
Negative_regulation (reduction) of Localization (release) of TNF-alpha
18) Confidence 0.55 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16996482 Disease Relevance 0.23 Pain Relevance 0.22
The corticosteroid budesonide inhibited the TNF-alpha release dose dependently with an IC(50) of 0.55+/-0.13 nM.
Negative_regulation (inhibited) of Localization (release) of TNF-alpha associated with corticosteroid
19) Confidence 0.55 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16996482 Disease Relevance 0.53 Pain Relevance 0.28
Surprisingly, TNF alpha release from AM upon in vitro activation was significantly decreased during rejection.
Negative_regulation (decreased) of Localization (release) of TNF alpha
20) Confidence 0.55 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8906220 Disease Relevance 0.50 Pain Relevance 0.21

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