INT53584

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 8
Speculated 2
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 14.38
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
liver 2
lungs 2
brain 1
endometrium 1
hippocampus 1
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 6 99.54 Very High Very High Very High
Morphine 6 99.22 Very High Very High Very High
Hippocampus 22 99.04 Very High Very High Very High
Inflammation 85 96.52 Very High Very High Very High
ischemia 64 96.12 Very High Very High Very High
endometriosis 12 94.00 High High
Neurotransmitter 1 92.08 High High
anesthesia 9 91.84 High High
Paracetamol 12 90.56 High High
cINOD 2 89.80 High High
Disease Link Frequency Relevance Heat
Adenocarcinoma 40 99.48 Very High Very High Very High
Stress 229 99.40 Very High Very High Very High
Myoma 42 99.40 Very High Very High Very High
Diabetes Mellitus 67 99.28 Very High Very High Very High
Polyps 48 99.04 Very High Very High Very High
Heart Rate Under Development 52 98.84 Very High Very High Very High
Pressure And Volume Under Development 10 98.76 Very High Very High Very High
Middle Cerebral Artery Infarction 56 98.48 Very High Very High Very High
Urological Neuroanatomy 24 98.40 Very High Very High Very High
Cancer 27 98.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metabolic regulation and function of glutathione peroxidase-1.
Regulation (regulation) of glutathione peroxidase-1
1) Confidence 0.62 Published 2007 Journal Annu. Rev. Nutr. Section Title Doc Link 17465855 Disease Relevance 0.74 Pain Relevance 0.11
We also detected the changes in the activities of superoxide dismutase (SOD), glutathione reductase (GRx) and glutathione peroxidase (GPx) of liver in the lambda-carrageenan-induced paw edema in mice to investigate the anti-inflammatory mechanism of FL and FM.
Regulation (changes) of GPx in paw associated with pressure and volume under development and inflammation
2) Confidence 0.57 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503477 Disease Relevance 0.67 Pain Relevance 0.39
Equally, comparative effects of these plants on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), gluthathione peroxidase (GPx), and delta-aminolevulinate dehydratase (delta-ALA-D) activities, were also evaluated in the mouse liver homogenate.
Regulation (effects) of GPx in liver
3) Confidence 0.28 Published 2008 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 18054472 Disease Relevance 0.57 Pain Relevance 0.53
Although the significance of alteration in GPx activity remains unclear, it is most likely related to enhanced generation of lipoperoxides.
Regulation (alteration) of GPx
4) Confidence 0.15 Published 1999 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 10954129 Disease Relevance 0 Pain Relevance 0.07
There was no difference in GPx activity in adenocarcinoma patients in comparison to polyps or myoma patients (p > 0.05).
Neg (no) Regulation (difference) of GPx associated with adenocarcinoma, polyps and myoma
5) Confidence 0.13 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 2.57 Pain Relevance 0
We have investigated its effects on two major antioxidative enzymes, catalase and glutathione peroxidase (GPx).
Spec (investigated) Regulation (effects) of GPx
6) Confidence 0.12 Published 1997 Journal Free Radic. Biol. Med. Section Abstract Doc Link 9034240 Disease Relevance 0.16 Pain Relevance 0.08
Punnonen et al. [14] detected higher GPx activity in cancer than in normal endometrium of the Finnish population while in Japanese women no change of GPx activity was recorded.
Neg (no) Regulation (change) of GPx in endometrium associated with cancer
7) Confidence 0.11 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 1.56 Pain Relevance 0.14
In view of our findings that the extract had no effect on the activities of GPx and GR reductase, we suggest that T.
Neg (no) Regulation (effect) of GPx
8) Confidence 0.09 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC3005810 Disease Relevance 0 Pain Relevance 0
At the same time, we found that the extract had no effect on the activities of GPx and GR.
Neg (no) Regulation (effect) of GPx
9) Confidence 0.09 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC3005810 Disease Relevance 0 Pain Relevance 0
RPE caused significantly increased MDA levels, and decreased GPx and SOD activity in lung tissue in our study.
Regulation (activity) of GPx in lung associated with heart rate under development
10) Confidence 0.08 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2583976 Disease Relevance 1.11 Pain Relevance 0.09
Therefore, we decided to study the protective effect of taurine in ibuprofen-induced gastropathy and the effects of administration of taurine on the endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), and reduced glutathione (GSH) of stomach.
Regulation (effects) of GPX in stomach
11) Confidence 0.08 Published 2004 Journal ScientificWorldJournal Section Abstract Doc Link 15632983 Disease Relevance 0.18 Pain Relevance 0.18
It is concluded that HTX rats are more resistant to oxidative and nitrosative stress and renal damage induced by IR, which is not mediated by a differential regulation of the antioxidant enzymes CAT, GPx, and SOD.


Regulation (regulation) of GPx associated with stress
12) Confidence 0.07 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1291371 Disease Relevance 0.65 Pain Relevance 0.10
Morphine and/or naloxone did not significantly affect erythrocyte superoxide dismutase (SOD-1), glutathione peroxidase (GPx) and catalase activities or malonyldialdehyde (MDA) concentrations in venous blood during renal ischemia.
Neg (not) Regulation (affect) of GPx in blood associated with ischemia, narcan and morphine
13) Confidence 0.07 Published 1994 Journal Exp. Nephrol. Section Abstract Doc Link 7859038 Disease Relevance 0.31 Pain Relevance 0.95
Kidney morphology and the levels of urea, creatinine and nitric oxide metabolites (NOx) in the plasma and the enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the level of malondialdehyde (MDA) in the kidney were determined.
Spec (determined) Regulation (determined) of GPx in kidney
14) Confidence 0.06 Published 2004 Journal Ren Fail Section Abstract Doc Link 15526905 Disease Relevance 0.36 Pain Relevance 0.13
Table 3 shows the effects of PPE on liver SOD, CAT and GPx.
Regulation (effects) of GPx in liver
15) Confidence 0.06 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2950386 Disease Relevance 1.08 Pain Relevance 0
Catalase and GPX isoforms are responsible for the removal of H2O2 as well as other organic hydroperoxides, whereas SOD isoforms operate by transforming O2•- into H2O2 (Figure 7).


Regulation (responsible) of GPX
16) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.25 Pain Relevance 0.04
It was found that SAMC itself was unable to modify the activity of Mn-SOD, Cu,Zn-SOD, GPx and GR but it decreased CAT activity (Table 2).
Neg (unable) Regulation (modify) of GPx
17) Confidence 0.03 Published 2004 Journal BMC Clin Pharmacol Section Body Doc Link PMC419708 Disease Relevance 0.39 Pain Relevance 0
However, no significant changes in GSH, GPx, GR and GST levels of hippocampus and frontal cortex were observed in the rats treated only with the aqueous extract of Embelia ribes, as compared to the sham rats [Tables 3 and 4].


Neg (no) Regulation (changes) of GPx in frontal cortex associated with urological neuroanatomy and hippocampus
18) Confidence 0.03 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 1.04 Pain Relevance 0.20
In the present investigation, the intratracheal instillation of LPS into the lungs of Golden Syrian hamsters was sufficient to induce an oxidative stress manifested by increased formation of MDA, decreased GSH, and altered activities of CAT, GPx and SOD.
Regulation (altered) of GPx in lungs associated with stress
19) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994390 Disease Relevance 0.35 Pain Relevance 0.06
Effects of oxidative stress were also confirmed based on alterations in antioxidant enzymes, GPx, GST and SOD in rat brain.
Regulation (alterations) of GPx in brain associated with stress
20) Confidence 0.02 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19460394 Disease Relevance 0.70 Pain Relevance 0.17

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