INT53590

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 33
Total Number 35
Disease Relevance 23.46
Pain Relevance 10.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1)
plasma membrane (PRF1)
Anatomy Link Frequency
T cells 17
NK cells 4
cytotoxic T cells 4
blood 1
sciatic nerve 1
PRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatic nerve 2 99.84 Very High Very High Very High
cytokine 92 99.28 Very High Very High Very High
Neuritis 11 99.06 Very High Very High Very High
spinal inflammation 979 98.76 Very High Very High Very High
tetrodotoxin 5 96.52 Very High Very High Very High
Arthritis 220 92.96 High High
Inflammation 97 92.28 High High
rheumatoid arthritis 345 92.04 High High
Peripheral nervous system 4 91.48 High High
corticosteroid 6 82.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 190 100.00 Very High Very High Very High
Necrosis 67 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 11 99.06 Very High Very High Very High
Low Back Pain 1039 98.76 Very High Very High Very High
Communicable Diseases 6 98.56 Very High Very High Very High
Synovitis 12 98.48 Very High Very High Very High
Disease 398 97.28 Very High Very High Very High
Autoimmune Disease 19 96.72 Very High Very High Very High
Apoptosis 57 95.84 Very High Very High Very High
Syndrome 23 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perforin was found in CD4+CD28- peripheral blood lymphocytes, and CD4+ perforin-positive T cells were present in the synovial tissue, where their frequency correlated with the expansion of the CD4+CD28- T-cell compartment in the periphery [10].
Gene_expression (present) of perforin in blood
1) Confidence 0.58 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165060 Disease Relevance 0.38 Pain Relevance 0.03
Perforin, a cytolytic factor, was expressed in the infiltrating CTLs and NK cells, indicating that these cells were activated killer cells.
Gene_expression (expressed) of Perforin in NK cells
2) Confidence 0.55 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.98 Pain Relevance 0.08
Perforin, a cytolytic factor, was expressed in the infiltrating CTLs and NK cells, indicating that these cells were activated killer cells.
Gene_expression (expressed) of Perforin in CTLs
3) Confidence 0.19 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10084393 Disease Relevance 0.98 Pain Relevance 0.08
To study the potential role of cytokines in EAN, we used in situ hybridization to detect mRNA expression of interleukin 1 beta (IL-1 beta), IL-6, IL-10, IL-12, tumor necrosis factor-alpha (TNF-alpha), TNF-beta, and cytolysin in sciatic nerve sections over the course of EAN.
Gene_expression (expression) of cytolysin in sciatic nerve associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
4) Confidence 0.16 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.45 Pain Relevance 1.22
CD8+CD28- T cells have been reported to be effector cells, producing perforin, granzyme B, tumour necrosis factor-?
Gene_expression (producing) of perforin in T cells associated with necrosis and cancer
5) Confidence 0.13 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.24 Pain Relevance 0.37
For intracellular detection of perforin or IFN-?
Gene_expression (detection) of perforin
6) Confidence 0.10 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.30 Pain Relevance 0.18
For intracellular detection of perforin or interferon-?
Gene_expression (detection) of perforin
7) Confidence 0.10 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.95 Pain Relevance 0.43
Circulating CD8+ CD28- T cells (characterized by a lack of the CD28 co-stimulatory molecule on the cell surface and production of perforin) are increased not only in various infectious diseases but also in patients with autoimmune diseases like AS.
Gene_expression (production) of perforin in T cells associated with spinal inflammation, autoimmune disease and communicable diseases
8) Confidence 0.10 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.58 Pain Relevance 0.39
We examined the effects of sulfhydryloxidizing and -reducing agents on the function of the heterologously expressed pore-forming subunits of the cloned rabbit smooth muscle L-type Ca2+ channel and the human cardiac tetrodotoxin-insensitive Na+ channel.
Gene_expression (expressed) of pore-forming in smooth muscle associated with tetrodotoxin
9) Confidence 0.09 Published 1995 Journal Circ. Res. Section Abstract Doc Link 7859379 Disease Relevance 0 Pain Relevance 0.10
Production of perforin was more frequent in CD28- CD8+ T cells (83.9 ± 17.3% versus 1.6 ± 1.2% stained with IgG control antibodies) than in their CD28+ counterparts (21.3 ± 12.0% versus 3.8 ± 1.8% stained with IgG control antibodies) (P < 0.001) (Fig. 3a).
Gene_expression (Production) of perforin in T cells
10) Confidence 0.09 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.62 Pain Relevance 0.45
Most of the CD8+ CD28- T cells produced perforin after stimulation in vitro, in contrast to their CD8+CD28+ counterparts.
Gene_expression (produced) of perforin in T cells
11) Confidence 0.09 Published 2002 Journal Arthritis Res Section Abstract Doc Link PMC64855 Disease Relevance 0.36 Pain Relevance 0.18
As shown in Figure 4a,b, perforin was produced upon LPS stimulation by CD4+CD28null T cells (13 ± 10.7% perforin+ cells), but perforin expression was negligible in CD4+CD28+ T cells (0.4% ± 0.3% perforin+ cells, P = 0.009).
Gene_expression (expression) of perforin in T cells
12) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.36 Pain Relevance 0.24
We demonstrate an intense infiltration of the affected lymph node by cytotoxic T-cells expressing CD8, perforin, and granzymeB.
Gene_expression (expressing) of perforin in cytotoxic T-cells
13) Confidence 0.07 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853499 Disease Relevance 1.56 Pain Relevance 0.09
LPS-mediated perforin production of CD4+CD28null T cells depends on CD14 and TLR4
Gene_expression (production) of perforin in T cells
14) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.69 Pain Relevance 0.42
Taking these facts together, activated CD4+CD28null T cells produce perforin upon LPS-mediated activation in a CD14-dependent and TLR4-dependent manner.
Gene_expression (produce) of perforin in T cells
15) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.50 Pain Relevance 0.37
CD4+CD28+ T cells did not produce perforin after co-incubation with LPS, even after addition of sCD14 or autologous serum (Figure 4a and data not shown).
Neg (not) Gene_expression (produce) of perforin in T cells
16) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.23 Pain Relevance 0.23
In our experiments both the addition of recombinant sCD14 and autologous serum had a comparable additional effect on LPS-induced perforin production of CD4+CD28null T cells, which indicates serum LPS binding protein not to be indispensable in AS.
Neg (not) Gene_expression (production) of perforin in T cells associated with spinal inflammation
17) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.59 Pain Relevance 0.39
For functional testing of TLR-mediated lymphocytic stimulation, fresh PBMCs were incubated for 16 hours with LPS and the T cells were analysed for their intracellular production of perforin.
Spec (analysed) Gene_expression (production) of perforin in T cells
18) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.50 Pain Relevance 0.32
As expected, LPS-induced perforin production of CD4+CD28null T cells was reversed by blocking sCD14 and mCD14 (24.0 ± 16.3% versus 3.1 ± 2.5% perforin+ cells, P = 0.006) but not by isotype control antibody (Figure 5b).
Gene_expression (production) of perforin in T cells
19) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.24 Pain Relevance 0.24
Blocking assays with antibodies directed against TLR4 were then performed to specifically address the role of TLR4 in LPS-mediated perforin production of CD4+CD28null T cells.
Gene_expression (production) of perforin in T cells
20) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.20 Pain Relevance 0.20

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