INT536

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Context Info
Confidence 0.48
First Reported 1975
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.52
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MBP)
Anatomy Link Frequency
eosinophil 3
optic nerve 3
cerebral white matter 1
B cells 1
CSF 1
MBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 169 99.42 Very High Very High Very High
Demyelination 9 99.42 Very High Very High Very High
Inflammation 29 98.84 Very High Very High Very High
Neuritis 31 98.54 Very High Very High Very High
Central nervous system 19 97.24 Very High Very High Very High
addiction 5 59.12 Quite High
local anesthetic 2 58.96 Quite High
c fibre 4 58.24 Quite High
cytokine 6 48.24 Quite Low
chemokine 10 47.36 Quite Low
Disease Link Frequency Relevance Heat
Disease 55 99.76 Very High Very High Very High
Demyelinating Disease 189 99.42 Very High Very High Very High
Shock 10 99.12 Very High Very High Very High
INFLAMMATION 33 98.84 Very High Very High Very High
Optic Neuritis 29 98.54 Very High Very High Very High
Asthma 88 94.24 High High
Autoimmune Disease 20 86.32 High High
Recurrence 49 83.56 Quite High
Alzheimer's Dementia 8 78.72 Quite High
Hypersensitivity 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of the optic nerve demyelination may be associated with anti-MBP binding in situ to MBP in the 61-106 amino acid region.
MBP Binding (binding) of in optic nerve associated with demyelination
1) Confidence 0.48 Published 1992 Journal J. Neurol. Sci. Section Abstract Doc Link 1381412 Disease Relevance 0.51 Pain Relevance 0.37
The mechanism of the optic nerve demyelination may be associated with anti-MBP binding in situ to MBP in the 61-106 amino acid region.
MBP Binding (binding) of in optic nerve associated with demyelination
2) Confidence 0.48 Published 1992 Journal J. Neurol. Sci. Section Abstract Doc Link 1381412 Disease Relevance 0.52 Pain Relevance 0.37
Moreover, these investigators determined that, in antigen-challenged guinea pigs, MBP may allosterically bind to M2 muscarinics receptor thereby inducing AHR in vivo [48, 49].
MBP Binding (bind) of
3) Confidence 0.48 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.25 Pain Relevance 0.06
Though the eosinophil transports MBP in a solubilized form within specialized acidified granules to prevent its precipitation and premature binding to cells [37], the application of purified MBP directly to tissues and cells is problematic.
MBP Binding (binding) of in eosinophil
4) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0.03
Though the eosinophil transports MBP in a solubilized form within specialized acidified granules to prevent its precipitation and premature binding to cells [37], the application of purified MBP directly to tissues and cells is problematic.
MBP Binding (binding) of in eosinophil
5) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0.03
Incubation of Bronchial Segments or Airway Cells with Eosinophils or MBP
MBP Binding (Incubation) of in Eosinophils
6) Confidence 0.37 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.06 Pain Relevance 0
Three to 5 months after the acute phase when the majority of patients have recovered, free/bound anti-MBP ratios are below unity with low titers of free antibody and relatively higher levels of bound anti-MBP.
MBP Binding (bound) of
7) Confidence 0.36 Published 1992 Journal J. Neurol. Sci. Section Abstract Doc Link 1381412 Disease Relevance 0.57 Pain Relevance 0.41
In 53 optic neuritis patients free anti-MBP was elevated in 47 and in 6 of these 47 patients bound anti-MBP was also increased.
anti-MBP Binding (bound) of in optic associated with optic neuritis and neuritis
8) Confidence 0.31 Published 1994 Journal J. Neurol. Sci. Section Abstract Doc Link 7510787 Disease Relevance 0.99 Pain Relevance 0.60
Enemas were made use of at seven centres and one centre performed orthograde lavage; 14 hospitals did not use any kind of MBP before left pancreatectomy (Table 2).


MBP Neg (not) Binding (kind) of
9) Confidence 0.23 Published 2009 Journal Trials Section Body Doc Link PMC2726965 Disease Relevance 0 Pain Relevance 0
Such comparisons have led to investigations of osteopontin (OPN), myelin basic protein (MBP), IFN-?
myelin basic protein Binding (investigations) of
10) Confidence 0.18 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.91 Pain Relevance 0.26
Primary demyelination of these fibres was induced by sensitization of the animals to bovine cerebral white matter or myelin basic protein in complete Freund's adjuvant and challenge thereafter by intravitreous injection of basic protein (BP) or purified tuberculin (PPD).
basic protein Binding (sensitization) of in cerebral white matter associated with demyelination
11) Confidence 0.14 Published 1975 Journal J. Neurol. Sci. Section Abstract Doc Link 46272 Disease Relevance 0.41 Pain Relevance 0.17
One set are proteins that are associated with Alzheimer’s disease, including myelin basic protein, 14-3-3 protein, syntaxin binding protein munc18, transketolase, heat shock protein HSP70, reelin, and calcium/calmodulin kinase II (Table 1).
myelin basic protein Binding (syntaxin binding protein munc18) of associated with shock and disease
12) Confidence 0.11 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.63 Pain Relevance 0
The dyes had a higher affinity and quantum yield, when bound to the proteolipid (Kans=2.3x10--6,=0.67) than to the basic protein (Kans=3.3x10--5,=0.40).
basic protein Binding (bound) of
13) Confidence 0.10 Published 1975 Journal Biochemistry Section Abstract Doc Link 50085 Disease Relevance 0 Pain Relevance 0.06
The inserted cDNA fragments were expressed as a hybrid protein with maltose-binding protein (MBP).
MBP Binding (protein) of
14) Confidence 0.08 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165049 Disease Relevance 0 Pain Relevance 0
These results suggest that there are at least two immunologically distinct forms of MS, i.e., a common form highly associated with anti-MBP and more frequent prominent inflammatory characteristics in CSF and CNS, and an infrequent form associated with anti-PLP in CSF and tissue, and less abundant inflammation.
anti-MBP Binding (associated) of in CSF associated with multiple sclerosis, inflammation and central nervous system
15) Confidence 0.08 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 7510098 Disease Relevance 0.98 Pain Relevance 0.69
These two bands are not apparent under our typical 8-hour incubation (Fig. 3B; 8 h) and they do not react with anti-MBP (Fig. 3C), and thus we believe they might constitute unspecific cleavage products.
MBP Neg (not) Binding (react) of in cleavage
16) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0 Pain Relevance 0
Monosymptomatic unilateral optic neuritis (ON) is a common first manifestation of multiple sclerosis (MS) in which increased numbers of autoimmune T and B cells, recognizing different myelin autoantigens including myelin basic protein (MBP) and its peptides, have been implicated in a hypothetical immunopathogenesis.
basic protein Binding (recognizing) of in B cells associated with multiple sclerosis, optic neuritis and neuritis
17) Confidence 0.01 Published 1993 Journal Neurology Section Abstract Doc Link 7513391 Disease Relevance 0.69 Pain Relevance 0.52

General Comments

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