INT5363

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 6.49
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PEPD) cellular amino acid metabolic process (PEPD)
Anatomy Link Frequency
pancreas 2
skin 1
PEPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Nav1.7 109 100.00 Very High Very High Very High
Paroxysmal extreme pain disorder 102 100.00 Very High Very High Very High
addiction 44 99.54 Very High Very High Very High
dorsal root ganglion 91 93.92 High High
cINOD 6 93.56 High High
carbamazepine 22 92.56 High High
fibrosis 16 89.44 High High
Pain 59 87.56 High High
aspirin 9 75.20 Quite High
sodium channel 30 73.80 Quite High
Disease Link Frequency Relevance Heat
Somatoform Disorder 103 100.00 Very High Very High Very High
Erythermalgia 50 100.00 Very High Very High Very High
Prolidase Deficiency 12 100.00 Very High Very High Very High
Stress 48 99.40 Very High Very High Very High
Reprotox - General 2 16 99.04 Very High Very High Very High
Skin Ulcer 4 96.00 Very High Very High Very High
Intellectual Impairment 4 95.48 Very High Very High Very High
Ganglion Cysts 93 93.92 High High
Infection 4 93.80 High High
INFLAMMATION 10 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These phenomena were accompanied by over 10-fold decrease in prolidase activity and marked decrease in prolidase expression.
Negative_regulation (decrease) of prolidase
1) Confidence 0.56 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.13 Pain Relevance 0
RESULTS: In pancreatitis tissue, an increase in collagen content, collagenolytic activity and beta 1 integrin expression were accompanied by significant decrease (about 2-fold) in prolidase activity and marked decrease in its expression, compared to normal pancreas.
Negative_regulation (decrease) of prolidase in pancreas
2) Confidence 0.56 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.16 Pain Relevance 0
RESULTS: In cells treated with acetylsalicylic acid, a concomitant decrease in prolidase activity, prolidase phosphorylation (at the threonine residue), and collagen biosynthesis were observed.
Negative_regulation (decrease) of prolidase
3) Confidence 0.53 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
This suggests that a decrease in prolidase activity may contribute to a decrease in the biosynthesis of proline-containing proteins, such as collagen and SOS.
Negative_regulation (decrease) of prolidase
4) Confidence 0.53 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction

OBJECTIVES:

Negative_regulation (inhibitor) of prolidase associated with reprotox - general 2
5) Confidence 0.43 Published 2010 Journal Clinics (Sao Paulo) Section Title Doc Link PMC3020342 Disease Relevance 0.28 Pain Relevance 0
In addition, reduced prolidase activity also confirms the reduced oxidative stress under the action of tadalafil citrate—a topic still debated in the literature.
Negative_regulation (reduced) of prolidase associated with stress
6) Confidence 0.43 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020342 Disease Relevance 1.22 Pain Relevance 0.08
Hereditary prolidase deficiency—a multisystemic disorder—is characterized by a wide spectrum of clinical manifestations, including skin ulcers, mental retardation, and susceptibility to infections.
Negative_regulation (deficiency) of prolidase in skin associated with prolidase deficiency, intellectual impairment, skin ulcer and infection
7) Confidence 0.43 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020342 Disease Relevance 0.89 Pain Relevance 0
Oxidative stress results in collagen degradation and this process is mediated by prolidase.12 Moreover, the degree of severity of oxidative stress is directly related to the inhibition of collagen production, and prolidase is thought to be the target enzyme of this process.20 Our study showed that tadalafil citrate significantly reduced prolidase activity at the peak serum level.
Negative_regulation (reduced) of prolidase associated with stress
8) Confidence 0.43 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020342 Disease Relevance 1.06 Pain Relevance 0.07
RESULTS: In pancreatitis tissue, an increase in collagen content, collagenolytic activity and beta 1 integrin expression were accompanied by significant decrease (about 2-fold) in prolidase activity and marked decrease in its expression, compared to normal pancreas.
Negative_regulation (decrease) of prolidase in pancreas
9) Confidence 0.42 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.16 Pain Relevance 0
The mechanism of their action on collagen biosynthesis involves inactivation of prolidase, the enzyme that recovers proline from collagen degradation products for collagen re-synthesis.
Negative_regulation (inactivation) of prolidase
10) Confidence 0.39 Published 2004 Journal Med. Sci. Monit. Section Abstract Doc Link 15173663 Disease Relevance 0.09 Pain Relevance 0.26
In contrast, PEPD mutations in Nav1.7 impair fast-inactivation and can result in a persistent current [19].
Negative_regulation (inactivation) of PEPD associated with paroxysmal extreme pain disorder and nav1.7
11) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 1.46 Pain Relevance 1.15
Our observations of a 19 mV depolarizing shift in the voltage-dependence of fast-inactivation for M1627K confirm the linkage of impaired fast-inactivation of Nav1.7 and PEPD reported by Fertleman et al [19].
Negative_regulation (inactivation) of PEPD associated with addiction, paroxysmal extreme pain disorder and nav1.7
12) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2556659 Disease Relevance 0.52 Pain Relevance 0.97
In addition to the shifts in the voltage-dependence of activation or fast-inactivation of IEM and PEPD mutations, ramp currents are significantly bigger for IEM and PEPD mutant channels, compared to WT [2].
Negative_regulation (inactivation) of PEPD associated with addiction, paroxysmal extreme pain disorder and erythermalgia
13) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2898769 Disease Relevance 0.54 Pain Relevance 0.55
All aminoacyl hydrolase activities tested were inhibited by bestatin and o-phenanthroline, but not by inhibitors of serine, cysteine and aspartic proteases, suggesting they are metalloaminopeptidases.
Negative_regulation (inhibited) of aminoacyl hydrolase
14) Confidence 0.00 Published 1992 Journal Neurochem. Int. Section Abstract Doc Link 1303734 Disease Relevance 0 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox