INT53631

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Context Info
Confidence 0.03
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.00
Pain Relevance 8.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
Morph1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 152 100.00 Very High Very High Very High
antinociception 30 100.00 Very High Very High Very High
narcan 35 99.98 Very High Very High Very High
opioid receptor 11 99.84 Very High Very High Very High
Patient controlled alalgesia 14 98.72 Very High Very High Very High
Analgesic 11 97.96 Very High Very High Very High
Pain 6 97.88 Very High Very High Very High
Opioid 7 96.60 Very High Very High Very High
antagonist 12 96.40 Very High Very High Very High
aspirin 12 94.84 High High
Disease Link Frequency Relevance Heat
Nociception 43 93.24 High High
Sleep Disorders 2 92.88 High High
Sprains And Strains 2 89.68 High High
Pain 5 78.92 Quite High
Schizophrenia 4 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This combination reduces the dose requirement of morphine and therefore some of the morphine-related untoward effects.
Positive_regulation (requirement) of morphine associated with morphine
1) Confidence 0.03 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10512278 Disease Relevance 0.21 Pain Relevance 1.80
This combination reduces dose requirements of morphine and hence some of its adverse effects.
Positive_regulation (requirements) of morphine associated with morphine
2) Confidence 0.03 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10512278 Disease Relevance 0.24 Pain Relevance 2.17
Together, our data show that STOP null mice displayed elevated levels of endogenous morphine, as well as an increase of morphine receptor affinity and density in brain.
Positive_regulation (increase) of morphine receptor in brain associated with morphine
3) Confidence 0.02 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3017033 Disease Relevance 0.33 Pain Relevance 0.93
The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that it is a non-opioid response.
Positive_regulation (induced) of antinociception associated with antinociception, narcan and opioid
4) Confidence 0.00 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862870 Disease Relevance 0.08 Pain Relevance 1.05
A possible role of 5-HT2 receptors in the antinociception induced by opioid receptor blockade is discussed.
Positive_regulation (induced) of antinociception associated with antinociception and opioid receptor
5) Confidence 0.00 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862870 Disease Relevance 0.07 Pain Relevance 0.96
Effects of acute selective 5-HT1, 5-HT2, 5-HT3 receptor and alpha 2 adrenoceptor blockade on naloxone-induced antinociception.
Positive_regulation (induced) of antinociception associated with antinociception, analgesic and narcan
6) Confidence 0.00 Published 1994 Journal Psychopharmacology (Berl.) Section Title Doc Link 7862870 Disease Relevance 0.08 Pain Relevance 1.42

General Comments

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