INT53631

Context Info Confidence 0.03 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 1.00 Pain Relevance 8.32

Anatomy Link Frequency brain 1 Morph1 (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 152 100.00 antinociception 30 100.00 narcan 35 99.98 opioid receptor 11 99.84 Patient controlled alalgesia 14 98.72 Analgesic 11 97.96 Pain 6 97.88 Opioid 7 96.60 antagonist 12 96.40 aspirin 12 94.84

Disease Link Frequency Relevance Heat Nociception 43 93.24 Sleep Disorders 2 92.88 Sprains And Strains 2 89.68 Pain 5 78.92 Schizophrenia 4 5.00 Stress 3 5.00 Hyperalgesia 2 5.00 Neuroblastoma 1 5.00 Targeted Disruption 1 5.00 Congenital Anomalies 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This combination reduces the dose requirement of morphine and therefore some of the morphine-related untoward effects.

Positive_regulation (requirement) of morphine associated with morphine

1) Confidence 0.03 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10512278 Disease Relevance 0.21 Pain Relevance 1.80

This combination reduces dose requirements of morphine and hence some of its adverse effects.

Positive_regulation (requirements) of morphine associated with morphine

2) Confidence 0.03 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10512278 Disease Relevance 0.24 Pain Relevance 2.17

Together, our data show that STOP null mice displayed elevated levels of endogenous morphine, as well as an increase of morphine receptor affinity and density in brain.

Positive_regulation (increase) of morphine receptor in brain associated with morphine

3) Confidence 0.02 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3017033 Disease Relevance 0.33 Pain Relevance 0.93

The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that it is a non-opioid response.

Positive_regulation (induced) of antinociception associated with antinociception, narcan and opioid

4) Confidence 0.00 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862870 Disease Relevance 0.08 Pain Relevance 1.05

A possible role of 5-HT2 receptors in the antinociception induced by opioid receptor blockade is discussed.

Positive_regulation (induced) of antinociception associated with antinociception and opioid receptor

5) Confidence 0.00 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862870 Disease Relevance 0.07 Pain Relevance 0.96

Effects of acute selective 5-HT1, 5-HT2, 5-HT3 receptor and alpha 2 adrenoceptor blockade on naloxone-induced antinociception.

Positive_regulation (induced) of antinociception associated with antinociception, analgesic and narcan

6) Confidence 0.00 Published 1994 Journal Psychopharmacology (Berl.) Section Title Doc Link 7862870 Disease Relevance 0.08 Pain Relevance 1.42

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