INT53648

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Context Info
Confidence 0.23
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Acot1, Calca) mitochondrion (Acot1) aging (Calca)
intracellular (Calca) lipid metabolic process (Acot1) cytosol (Acot1)
Anatomy Link Frequency
outflow 2
nerves 2
trachea 2
Acot1 (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 24 100.00 Very High Very High Very High
qutenza 13 99.40 Very High Very High Very High
Nicotine 16 98.64 Very High Very High Very High
antagonist 2 72.72 Quite High
Neuropeptide 2 65.28 Quite High
Potency 1 62.32 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The elevation of CGRP release by ACh was absent in capsaicin-desensitized preparations, suggesting that the release of peptide is derived from capsaicin-sensitive afferent nerves.
ACh Positive_regulation (elevation) of Localization (release) of CGRP in nerves associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.23 Published 1994 Journal Neuroreport Section Abstract Doc Link 7865762 Disease Relevance 0 Pain Relevance 0.44
Physostigmine and neostigmine did not alter resting release of CGRP from rat trachea, although exogenous (10(-5) M) ACh-induced CGRP release was enhanced in the presence of neostigmine, suggesting minimal tonic cholinergic activity in this model.
ACh Positive_regulation (induced) of Localization (release) of CGRP in trachea associated with calcitonin gene-related peptide
2) Confidence 0.13 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 8045845 Disease Relevance 0 Pain Relevance 1.06
Hexamethonium and mecamylamine blocked the effect of nicotine but not that of ACh, whereas atropine significantly attenuated the release of CGRP outflow induced by ACh.
ACh Positive_regulation (induced) of Localization (release) of CGRP in outflow associated with nicotine and calcitonin gene-related peptide
3) Confidence 0.12 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 8045845 Disease Relevance 0 Pain Relevance 1.11

General Comments

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