INT53666

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Context Info
Confidence 0.37
First Reported 1995
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.30
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Furin) peptidase activity (Furin) extracellular space (Furin)
Golgi apparatus (Furin) plasma membrane (Furin)
Furin (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 7 98.40 Very High Very High Very High
Dynorphin 15 89.52 High High
Enkephalin 9 77.84 Quite High
Neuropeptide 1 25.00 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 96.48 Very High Very High Very High
Insulinoma 4 75.00 Quite High
Metabolic Syndrome 8 55.68 Quite High
Cancer 4 49.28 Quite Low
Targeted Disruption 2 46.80 Quite Low
Body Weight 3 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Yersinia Infection 2 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to pro-Dyn mRNA, furin, PC1, and PC2 mRNA levels were not affected by 8-bromo-cAMP.
Neg (not) Regulation (not) of furin
1) Confidence 0.37 Published 1995 Journal Endocrinology Section Abstract Doc Link 7867572 Disease Relevance 0.07 Pain Relevance 0.41
The disruption of the PC2 gene does not lead to compensatory up-regulation in the levels of other convertases with similar substrate specificity because we find no significant changes in the levels of PC1, PC5/PC6, or furin in these mice as compared with wild-type mice.
Neg (no) Regulation (changes) of furin
2) Confidence 0.17 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.41
In contrast to pro-Dyn mRNA, furin, PC1, and PC2 mRNA levels were not affected by 8-bromo-cAMP.
Neg (not) Regulation (affected) of furin
3) Confidence 0.16 Published 1995 Journal Endocrinology Section Abstract Doc Link 7867572 Disease Relevance 0.07 Pain Relevance 0.41
In addition to the digestion-related genes described above, feeding regulated two other transcripts coding for highly important serine proteases, namely kallikrein and furin.
Regulation (regulated) of furin
4) Confidence 0.12 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC3017904 Disease Relevance 0.15 Pain Relevance 0

General Comments

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