INT53668

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Context Info
Confidence 0.53
First Reported 1995
Last Reported 2008
Negated 3
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.52
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pcsk1) extracellular space (Pcsk1) Golgi apparatus (Pcsk1)
Anatomy Link Frequency
brain 1
PC-3 1
Pcsk1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 11 99.84 Very High Very High Very High
Opioid 7 98.12 Very High Very High Very High
Sciatic nerve 2 96.28 Very High Very High Very High
Dynorphin 17 88.88 High High
Neuropeptide 2 81.52 Quite High
Enkephalin 10 77.56 Quite High
Pain 1 71.36 Quite High
antagonist 1 65.76 Quite High
Disease Link Frequency Relevance Heat
Cancer 15 100.00 Very High Very High Very High
Prostate Cancer 10 100.00 Very High Very High Very High
Death 1 99.98 Very High Very High Very High
Cold Sores 2 94.84 High High
Apoptosis 6 94.80 High High
Drug Induced Neurotoxicity 1 92.32 High High
Herpes Simplex Virus 2 86.40 High High
Reprotox - General 2 1 79.48 Quite High
Body Weight 3 79.04 Quite High
Insulinoma 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the levels of PC1 and PC2 are differentially altered in a number of brain regions and in the pituitary.
Regulation (altered) of PC1 in brain
1) Confidence 0.53 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11038363 Disease Relevance 0.15 Pain Relevance 0.12
In contrast to pro-Dyn mRNA, furin, PC1, and PC2 mRNA levels were not affected by 8-bromo-cAMP.
Neg (not) Regulation (not) of PC1
2) Confidence 0.52 Published 1995 Journal Endocrinology Section Abstract Doc Link 7867572 Disease Relevance 0.07 Pain Relevance 0.41
NV1023 had significant oncolytic effect on prostate carcinoma cells (PC3, DU145, and LNCap) in vitro.
Regulation (effect) of PC3 associated with prostate cancer
3) Confidence 0.24 Published 2008 Journal FASEB J. Section Abstract Doc Link 18234972 Disease Relevance 1.45 Pain Relevance 0.16
In contrast to pro-Dyn mRNA, furin, PC1, and PC2 mRNA levels were not affected by 8-bromo-cAMP.
Neg (not) Regulation (affected) of PC1
4) Confidence 0.23 Published 1995 Journal Endocrinology Section Abstract Doc Link 7867572 Disease Relevance 0.07 Pain Relevance 0.41
The disruption of the PC2 gene does not lead to compensatory up-regulation in the levels of other convertases with similar substrate specificity because we find no significant changes in the levels of PC1, PC5/PC6, or furin in these mice as compared with wild-type mice.
Neg (no) Regulation (changes) of PC1
5) Confidence 0.22 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.41
Here, we investigated the role of the vanilloid capsaicin in the death regulation of the human cancer androgen-resistant cell line PC-3.
Regulation (regulation) of PC-3 in PC-3 associated with qutenza, cancer and death
6) Confidence 0.13 Published 2006 Journal Apoptosis Section Abstract Doc Link 16374544 Disease Relevance 0.77 Pain Relevance 0.56

General Comments

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