INT53672

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2006
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.61
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pcsk1) extracellular space (Pcsk1) Golgi apparatus (Pcsk1)
Pcsk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 15 91.08 High High
Enkephalin 9 88.72 High High
Opioid 7 87.40 High High
Neuropeptide 1 25.00 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulinoma 4 75.00 Quite High
Cancer 9 60.16 Quite High
Targeted Disruption 2 57.68 Quite High
Sprains And Strains 3 15.64 Low Low
Teratoma 10 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Hematological Disease 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the ubiquitously expressed furin, beta TC3 cells have abundant levels of prohormone convertase-1 (PC1) and PC2 mRNAs, but undetectable levels of PACE4 or PC5 mRNAs.
Positive_regulation (levels) of prohormone convertase-1
1) Confidence 0.42 Published 1995 Journal Endocrinology Section Abstract Doc Link 7867572 Disease Relevance 0.30 Pain Relevance 0.41
In addition to the ubiquitously expressed furin, beta TC3 cells have abundant levels of prohormone convertase-1 (PC1) and PC2 mRNAs, but undetectable levels of PACE4 or PC5 mRNAs.
Positive_regulation (levels) of PC1
2) Confidence 0.42 Published 1995 Journal Endocrinology Section Abstract Doc Link 7867572 Disease Relevance 0.30 Pain Relevance 0.41
The disruption of the PC2 gene does not lead to compensatory up-regulation in the levels of other convertases with similar substrate specificity because we find no significant changes in the levels of PC1, PC5/PC6, or furin in these mice as compared with wild-type mice.
Neg (no) Positive_regulation (changes) of PC1
3) Confidence 0.40 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.41
Consistent with the global gene expression analysis, many genes known to be induced in early ectodermal differentiation of ESCs such as Isl1, Neurog3, Pax6 and Pcsk1 were not upregulated (fig. 2i).
Neg (not) Positive_regulation (upregulated) of Pcsk1
4) Confidence 0.26 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762397 Disease Relevance 0 Pain Relevance 0

General Comments

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