INT53673

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Context Info
Confidence 0.40
First Reported 1995
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.99
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Furin) peptidase activity (Furin) extracellular space (Furin)
Golgi apparatus (Furin) plasma membrane (Furin)
Anatomy Link Frequency
neurons 1
lung 1
Furin (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 40 97.80 Very High Very High Very High
Dynorphin 13 92.92 High High
Enkephalin 6 90.56 High High
Opioid 4 89.24 High High
nociceptor 16 87.20 High High
imagery 29 82.72 Quite High
c fibre 10 70.12 Quite High
cva 1 41.96 Quite Low
Neuropeptide 3 25.00 Low Low
Mechanotransduction 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 104 99.22 Very High Very High Very High
Metastasis 90 95.28 Very High Very High Very High
Carcinoma 16 91.52 High High
Severe Combined Immunodeficiency 18 84.40 Quite High
Targeted Disruption 17 81.80 Quite High
Lung Cancer 60 76.76 Quite High
Breast Cancer 4 76.28 Quite High
Insulinoma 2 75.00 Quite High
Rheumatoid Arthritis 33 58.80 Quite High
Alzheimer's Dementia 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the ubiquitously expressed furin, beta TC3 cells have abundant levels of prohormone convertase-1 (PC1) and PC2 mRNAs, but undetectable levels of PACE4 or PC5 mRNAs.
Gene_expression (expressed) of furin
1) Confidence 0.40 Published 1995 Journal Endocrinology Section Abstract Doc Link 7867572 Disease Relevance 0.31 Pain Relevance 0.40
The disruption of the PC2 gene does not lead to compensatory up-regulation in the levels of other convertases with similar substrate specificity because we find no significant changes in the levels of PC1, PC5/PC6, or furin in these mice as compared with wild-type mice.
Gene_expression (levels) of furin
2) Confidence 0.39 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.41
However, SA-mechanosensitive currents were not completely insensitive to protease treatment as the mean latency for current activation more than doubled in neurons pretreated with subtilisin, blisterase and furin (even at the lower dose of 10 U ml?
Gene_expression (with) of furin in neurons
3) Confidence 0.28 Published 2010 Journal EMBO J Section Body Doc Link PMC2810375 Disease Relevance 0.06 Pain Relevance 0.48
As shown in Fig. 2A, distinct morphological differences between the SPC-A-1sci cell line and its parental SPC-A-1 cell line were observed in cell culture.
Gene_expression (line) of SPC-A-1
4) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.48 Pain Relevance 0.05
Through three rounds of in vivo serial selection, the incidence of lung metastasis reached 100% in the fourth generation of the mouse model (Table 1), from which massive metastatic lesions were isolated (Fig. 1B) and s.c. implanted into new recipient mice, and the primary tumour was adapted to tissue culture for the generation of the SPC-A-1sci cell line.
Gene_expression (generation) of SPC-A-1sci in lung associated with cancer and metastasis
5) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912267 Disease Relevance 0.92 Pain Relevance 0.11
The overexpression of PC7 and furin in HEK cells transfected with ADAM10 resulted in a greater increase in sAPP?
Gene_expression (overexpression) of furin
6) Confidence 0.15 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.22 Pain Relevance 0.09

General Comments

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