INT53677

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Context Info
Confidence 0.35
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.28
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc3a1) plasma membrane (Slc3a1) carbohydrate metabolic process (Slc3a1)
Anatomy Link Frequency
nucleus accumbens 2
neurons 2
Slc3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 51 100.00 Very High Very High Very High
depression 72 99.70 Very High Very High Very High
Nucleus accumbens 7 99.68 Very High Very High Very High
Ventral tegmentum 2 99.68 Very High Very High Very High
Substantia nigra 2 98.60 Very High Very High Very High
antagonist 4 97.92 Very High Very High Very High
cerebral cortex 37 96.36 Very High Very High Very High
midbrain 3 96.08 Very High Very High Very High
Anterior cingulate cortex 2 91.40 High High
dopamine receptor 15 75.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 90 99.98 Very High Very High Very High
Depression 57 99.70 Very High Very High Very High
Stress 16 89.48 High High
Cognitive Disorder 11 76.64 Quite High
INFLAMMATION 10 62.68 Quite High
Post-partum Depression 30 50.00 Quite Low
Neurodegenerative Disease 5 41.80 Quite Low
Disease 6 40.64 Quite Low
Suicidal Behaviour 10 35.92 Quite Low
Cancer 4 14.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of haloperidol leads to an increase in striatal D2 receptor binding; however, studies examining striatal D2 receptor mRNA after haloperidol treatment report inconsistent results.
Positive_regulation (increase) of D2 Binding (binding) of
1) Confidence 0.35 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.26
Thus, increased striatal D2 binding after haloperidol treatment may not be the result of altered D2 gene activity in the striatum or midbrain, but could result from an increase in D2 mRNA in cingulate corticostriatal neurons and/or a longer half-life for the D2 receptor protein in striatal neurons.
Positive_regulation (increased) of D2 Binding (binding) of in neurons associated with midbrain
2) Confidence 0.33 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867758 Disease Relevance 0 Pain Relevance 0.38
We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.
Positive_regulation (induced) of D2 Binding (alteration) of associated with dopamine and diabetes mellitus
3) Confidence 0.12 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2890658 Disease Relevance 0.80 Pain Relevance 0.45
Decreased density of D2-like receptors was also observed in the nucleus accumbens core of the Wistar-Kyoto rat, another depression model, though D2-like receptor binding was increased in the nucleus accumbens shell [180].
Positive_regulation (increased) of D2 Binding (binding) of in nucleus accumbens associated with nucleus accumbens and depression
4) Confidence 0.05 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.48 Pain Relevance 0.47

General Comments

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