INT53684

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 14.36
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
neutrophils 21
granulocyte 9
monocytes 4
sputum 2
plasma 2
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 15 99.98 Very High Very High Very High
Fibrositis 7 99.34 Very High Very High Very High
Nicotine 106 99.00 Very High Very High Very High
Inflammation 235 98.98 Very High Very High Very High
cytokine 65 98.80 Very High Very High Very High
Inflammatory response 40 98.24 Very High Very High Very High
reflex sympathetic dystrophy 7 98.04 Very High Very High Very High
lidocaine 9 96.00 Very High Very High Very High
Regional anesthesia 1 93.52 High High
Pain 3 87.72 High High
Disease Link Frequency Relevance Heat
Adhesions 263 100.00 Very High Very High Very High
Stress 13 99.40 Very High Very High Very High
Fibromyalgia 6 99.34 Very High Very High Very High
Nicotine Addiction 441 99.32 Very High Very High Very High
INFLAMMATION 280 98.98 Very High Very High Very High
Diabetes Mellitus 4 98.24 Very High Very High Very High
Complex Regional Pain Syndromes 7 98.04 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 49 97.60 Very High Very High Very High
Inflammatory Bowel Disease 8 96.32 Very High Very High Very High
Pulmonary Disease 58 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Granulocyte phagocytosis activity, CD11b expression, and generation of reactive oxygen species were significantly reduced by lidocaine (P < 0.0002) and bupivacaine (P < 0.005) in the highest concentration (1,846 microm and 770 microm, respectively).
Negative_regulation (reduced) of Gene_expression (expression) of CD11b in Granulocyte
1) Confidence 0.59 Published 2003 Journal Anesthesiology Section Body Doc Link 12657844 Disease Relevance 0.07 Pain Relevance 0
Our results suggest that ropivacaine exerts anti-inflammatory activity, and this appears to be mediated through inhibiting the expression and function of adhesion molecule CD11b in neutrophils.
Negative_regulation (inhibiting) of Gene_expression (expression) of CD11b in neutrophils associated with inflammation and adhesions
2) Confidence 0.58 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.40 Pain Relevance 0.15
Ropivacaine inhibited CD11b expression in formyl-methionyl-leucyl-phenylalanine (fMLP)-activated neutrophils in a concentration-dependent manner, but not in a time-dependent manner.
Negative_regulation (inhibited) of Gene_expression (expression) of CD11b in neutrophils
3) Confidence 0.58 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20348036 Disease Relevance 0.41 Pain Relevance 0.37
Local anesthetics time-dependently inhibit staphylococcus aureus phagocytosis, oxidative burst and CD11b expression by human neutrophils.
Negative_regulation (inhibit) of Gene_expression (expression) of CD11b in neutrophils associated with local anesthetic
4) Confidence 0.58 Published 2008 Journal Reg Anesth Pain Med Section Title Doc Link 18675739 Disease Relevance 0.19 Pain Relevance 0.33
Polymorphonuclear (PMN) of H and M subjects also exhibited a very marked and similar reduction in the expression of CD11b/CD18 integrin receptors after fMLP treatment, with values that were less than 10% of those in controls, as observed by flow cytometry.
Negative_regulation (reduction) of Gene_expression (expression) of CD11b
5) Confidence 0.57 Published 1994 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7868301 Disease Relevance 0.31 Pain Relevance 0.47
In conclusion, Lido suppressed granulocyte adhesion to the endothelium and antiseptic capability by suppressing CD11b expression and/or ROS production.
Negative_regulation (suppressing) of Gene_expression (expression) of CD11b in granulocyte associated with adhesions
6) Confidence 0.51 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.10 Pain Relevance 0.17
Local anesthetics impair human granulocyte phagocytosis activity, oxidative burst, and CD11b expression in response to Staphylococcus aureus.
Negative_regulation (impair) of Gene_expression (expression) of CD11b in granulocyte associated with local anesthetic
7) Confidence 0.43 Published 2003 Journal Anesthesiology Section Title Doc Link 12657844 Disease Relevance 0 Pain Relevance 0.28
As compared to age and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p < 0.01) and CD11b/CD18 (p < 0.05) on polymorphonuclear leukocytes.
Negative_regulation (decreased) of Gene_expression (expression) of CD11b in polymorphonuclear leukocytes associated with fibrositis
8) Confidence 0.41 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19052753 Disease Relevance 0.78 Pain Relevance 0.39
As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis.
Negative_regulation (decreased) of Gene_expression (expression) of CD11b in plasma associated with stress and reflex sympathetic dystrophy
9) Confidence 0.41 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17702656 Disease Relevance 1.22 Pain Relevance 0.81
NF-kappaB activation, CD11b/CD18 expression, and the production of TNF-alpha, IL-8, and IL-6 in monocytes and granulocytes were inhibited by NCR in vitro.
Negative_regulation (inhibited) of Gene_expression (expression) of CD11b in granulocytes
10) Confidence 0.41 Published 2005 Journal Shock Section Abstract Doc Link 16044078 Disease Relevance 0.39 Pain Relevance 0.37
Using flow cytometric analysis, both local anesthetics were found to be effective in inhibiting the expression of Mac-1 (CD11b/CD18) in neutrophils.
Negative_regulation (inhibiting) of Gene_expression (expression) of CD11b in neutrophils associated with local anesthetic
11) Confidence 0.41 Published 2001 Journal Immunol. Lett. Section Abstract Doc Link 11410247 Disease Relevance 0.10 Pain Relevance 0.52
Systemic neutrophil activation was found in patients with unstable angina compared with those with stable angina assessed by cell surface CD11b expression and shedding of L-selectin (115.6 +/- 10.3 versus 74.0 +/- 6.3 anti-CD11b mean fluorescence intensity, P = .002; 49.8 +/- 6.0 versus 72.1 +/- 4.0 anti-L-selectin mean fluorescence intensity, P = .006).
Negative_regulation (shedding) of Gene_expression (expression) of CD11b in neutrophil
12) Confidence 0.41 Published 1996 Journal Circulation Section Body Doc Link 8822975 Disease Relevance 0.07 Pain Relevance 0
METHODS: We used flow cytometry analysis to determine peripheral blood neutrophil expression of L-selectin, CD11a, CD11b, CD31, CD43, CD44, and intercellular adhesion molecule 2 (ICAM-3) surface adhesion molecules after treatment with aceclofenac, diclofenac, or dexamethasone.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of CD11b in neutrophil
13) Confidence 0.31 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.19 Pain Relevance 0
RESULTS: The expression of CD11b and CD18 on neutrophils and neutrophil-dependent adhesion to endothelial cells elicited by HPE were inhibited by lansoprazole and omeprazole at clinical relevant doses, and the expression of ICAM-1 and VCAM-1 on endothelial cells and endothelial-dependent neutrophil adherence induced by IL-1beta were also inhibited by lansoprazole and omeprazole at similar doses.
Negative_regulation (inhibited) of Gene_expression (expression) of CD11b in neutrophil
14) Confidence 0.23 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807407 Disease Relevance 0.26 Pain Relevance 0
Thus increased expression of CD11b and decreased expression of CD62L by neutrophils and monocytes may play a central role as the mechanism by which leukocyte adhesion and consequently activation occurs following surgery [2], [21], [26].
Negative_regulation (decreased) of Gene_expression (expression) of CD11b in monocytes associated with adhesions
15) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.80 Pain Relevance 0.08
Ropivacaine inhibits leukocyte rolling, adhesion and CD11b/CD18 expression.
Negative_regulation (inhibits) of Gene_expression (expression) of CD11b/CD18 in leukocyte associated with adhesions
16) Confidence 0.20 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9336308 Disease Relevance 0.79 Pain Relevance 0.19
PDE4 inhibitors have a variety of anti-inflammatory effects on neutrophils, including inhibition of chemotaxis [73], suppression of proteolytic enzyme release, inhibition of proinflammatory cytokine release, particularly IL-8 and leukotriene B4 [74,75], and inhibition of CD11b integrin expression [73].
Negative_regulation (inhibition) of Gene_expression (expression) of CD11b in neutrophils associated with inflammation and cytokine
17) Confidence 0.17 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873624 Disease Relevance 1.65 Pain Relevance 0.54
It is also possible that smoking may not affect all smokers equally, and that a differential effect on CD18/CD11b expression could discriminate smokers at increased risk of developing COPD.
Negative_regulation (effect) of Gene_expression (expression) of CD11b associated with nicotine addiction and chronic obstructive pulmonary disease
18) Confidence 0.15 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 2.27 Pain Relevance 0
It is also possible that smoking may not affect all smokers equally, and that a differential effect on CD18/CD11b expression could discriminate smokers at increased risk of developing COPD.
Negative_regulation (effect) of Gene_expression (expression) of CD11b associated with nicotine addiction and chronic obstructive pulmonary disease
19) Confidence 0.15 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 2.27 Pain Relevance 0
Nitroblue tetrazolium reduction and expression of CD11b (?
Negative_regulation (reduction) of Gene_expression (expression) of CD11b
20) Confidence 0.15 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.08 Pain Relevance 0.25

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