INT53685

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Context Info
Confidence 0.39
First Reported 1994
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 5.39
Pain Relevance 7.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular_component (Sds)
cellular amino acid metabolic process (Sds) cytoplasm (Sds)
Anatomy Link Frequency
dorsal horn 4
neuronal 1
nerve 1
spinal cord 1
unspecified 1
Sds (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 532 100.00 Very High Very High Very High
Neuronal excitability 35 100.00 Very High Very High Very High
spinal dorsal horn 18 100.00 Very High Very High Very High
substance P 13 100.00 Very High Very High Very High
Paracetamol 11 99.34 Very High Very High Very High
allodynia 66 99.30 Very High Very High Very High
Pain 22 99.30 Very High Very High Very High
Sciatic nerve 30 99.28 Very High Very High Very High
Spinal cord 76 99.08 Very High Very High Very High
cytokine 88 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 476 99.42 Very High Very High Very High
Neuropathic Pain 186 99.30 Very High Very High Very High
Frailty 1 98.06 Very High Very High Very High
Autoimmune Disease 7 98.04 Very High Very High Very High
Experimental Arthritis 1 95.92 Very High Very High Very High
Multiple Sclerosis 1 94.96 High High
Experimental Autoimmune Encephalomyelitis 1 94.76 High High
Spinal Cord Injury 5 94.72 High High
Experimental Autoimmune Neuritis 1 92.88 High High
Pain 27 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, tetrodotoxin-induced disuse, which results in hindlimb atrophy and SDH decreases (30% decrease measured in medial gastrocnemius muscle homogenates), failed to alter soma SDH or size in unspecified lumbar motoneurons.
Neg (failed) Regulation (alter) of SDH in unspecified associated with tetrodotoxin and frailty
1) Confidence 0.39 Published 1994 Journal J. Appl. Physiol. Section Abstract Doc Link 7868444 Disease Relevance 0.18 Pain Relevance 0.21
In any case, the alterations in neonatal SDH synaptic function described here likely involve different mechanisms than those underlying the TNF?
Regulation (alterations) of SDH associated with dorsal horn
2) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.22 Pain Relevance 0.43
The effects of alteration of SP activity in SDH on immune responses and the pathogenesis of the autoimmune diseases were observed.
Regulation (alteration) of SDH in SDH associated with autoimmune disease, spinal dorsal horn and substance p
3) Confidence 0.26 Published 1996 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 9388989 Disease Relevance 0.78 Pain Relevance 1.09
to induce LTP in the dorsal horn following nerve injury [15] could result from a combination of changes in both SDH synaptic function and the intrinsic membrane properties of SDH neurons.
Regulation (changes) of SDH in dorsal horn associated with nervous system injury, dorsal horn and long-term potentiation
4) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.66 Pain Relevance 0.87
The present data demonstrate for the first time that the immature superficial dorsal horn (SDH) network becomes sensitive to the proinflammatory cytokine TNF?
Regulation (sensitive) of SDH in SDH associated with dorsal horn and cytokine
5) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.79 Pain Relevance 0.74
In contrast, inactivity induced by spinal cord hemisection at C2 (ST) resulted in much less change in SDH activity of type I and IIa fibers (approximately 27 and 24%, respectively) and only an approximately 30% reduction in SDH variability among fibers.
Regulation (change) of SDH in spinal cord associated with spinal cord
6) Confidence 0.19 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9104851 Disease Relevance 0 Pain Relevance 0.22
Although oral administration of 400 mg/kg acetaminophen (APAP) or 1.8-3.4 g/kg sucrose had no effect on serum levels of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH), their co-administration resulted in 20-fold increases in ALT/SDH activities.
Neg (no) Regulation (effect) of SDH associated with paracetamol
7) Confidence 0.13 Published 2000 Journal Xenobiotica Section Abstract Doc Link 11055270 Disease Relevance 0.16 Pain Relevance 0.57
However, neonatal sciatic nerve damage alone did not significantly modulate synaptic transmission or neuronal excitability in the SDH, which could reflect a relatively weak expression of TNF?
Neg (not) Regulation (modulate) of SDH in neuronal associated with nervous system injury, neuronal excitability, dorsal horn and sciatic nerve
8) Confidence 0.12 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2657778 Disease Relevance 1.01 Pain Relevance 0.81
Further evidence arises from recent behavioral work demonstrating that the activation of microglia in the neonatal dorsal horn with intrathecal injections of lipopolysaccharide (LPS) does evoke mechanical allodynia [7], suggesting that the immature SDH can be modulated by immune system activation.
Regulation (modulated) of SDH in dorsal horn associated with allodynia, dorsal horn and intrathecal
9) Confidence 0.10 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657778 Disease Relevance 0.70 Pain Relevance 0.99
Crosstalk between Spinal Astrocytes and Neurons in Nerve Injury-Induced Neuropathic Pain

Emerging research implicates the participation of spinal dorsal horn (SDH) neurons and astrocytes in nerve injury-induced neuropathic pain.

Regulation (participation) of SDH in nerve associated with pain, nervous system injury, spinal dorsal horn and neuropathic pain
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2736402 Disease Relevance 0.88 Pain Relevance 1.30

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